Search results for " 3.0"

showing 10 items of 601 documents

Evaluation of the antibacterial power and biocompatibility of zinc oxide nanorods decorated graphene nanoplatelets: New perspectives for antibiodeter…

2017

Background Nanotechnologies are currently revolutionizing the world around us, improving the quality of our lives thanks to a multitude of applications in several areas including the environmental preservation, with the biodeterioration phenomenon representing one of the major concerns. Results In this study, an innovative nanomaterial consisting of graphene nanoplatelets decorated by zinc oxide nanorods (ZNGs) was tested for the ability to inhibit two different pathogens belonging to bacterial genera frequently associated with nosocomial infections as well as biodeterioration phenomenon: the Gram-positive Staphylococcus aureus and the Gram-negative Pseudomonas aeruginosa. A time- and dose-…

3003Staphylococcus aureuslcsh:Medical technologyBiocompatibilitylcsh:Biotechnologyharmful to the environmentBiomedical EngineeringPharmaceutical ScienceMedicine (miscellaneous)Overall; ZNGs represent a promising candidate for developing biocompatible materials that can be exploitable in antimicrobial applications without releasing toxic compounds; harmful to the environment; Bioengineering; Medicine (miscellaneous); Molecular Medicine; Biomedical Engineering; Applied Microbiology and Biotechnology; 3003Biocompatible MaterialsBioengineeringNanotechnology02 engineering and technology010402 general chemistry01 natural sciencesApplied Microbiology and BiotechnologyNanomaterialsExtracellular polymeric substancelcsh:TP248.13-248.65HumansZNGs represent a promising candidate for developing biocompatible materials that can be exploitable in antimicrobial applications without releasing toxic compoundNanotubesbiologyChemistryResearchBiofilm021001 nanoscience & nanotechnologybiology.organism_classificationAntimicrobialAnti-Bacterial Agents0104 chemical scienceslcsh:R855-855.5NanotoxicologyBiofilmsPseudomonas aeruginosaZNGs; biodeterioration; antimicrobial nanomaterialMolecular MedicineGraphiteNanorodOverallZinc Oxide0210 nano-technologyBacteria
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Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin

2017

Gellan nanohydrogel and phospholipid vesicles were combined to incorporate baicalin in new self-assembling core-shell gellan-transfersomes obtained by an easy, scalable method. The vesicles were small in size (~107 nm) and monodispersed (P.I. ≤ 0.24), forming a viscous system (~24 mPa/s) as compared to transfersomes (~1.6 mPa/s), as confirmed by rheological studies. Gellan was anchored to the bilayer domains through cholesterol, and the polymer chains were distributed onto the outer surface of the bilayer, thus forming a core-shell structure, as suggested by SAXS analyses. The optimal carrier ability of core-shell gellan-transfersomes was established by the high deposition of baicalin in th…

3003SwinePharmaceutical ScienceMedicine (miscellaneous)02 engineering and technology01 natural sciencesMicechemistry.chemical_compoundDrug Delivery Systemsmaterials science (all)skin deliveryGeneral Materials ScienceSkinchemistry.chemical_classificationSkin repairSmall-angle X-ray scatteringBilayerVesicleAnti-Inflammatory Agents Non-SteroidalPolysaccharides BacterialPolymer021001 nanoscience & nanotechnologymedicine.anatomical_structureMolecular MedicineFemale0210 nano-technologytransfersomesSkin AbsorptionBiomedical EngineeringgellanBioengineeringAdministration Cutaneous010402 general chemistryIn vivo studiesDermisIn vivoSAXS analysismedicineAnimalsgellan; In vivo studies; rheological studies; SAXS analysis; skin delivery; transfersomes; bioengineering; medicine (miscellaneous); molecular medicine; biomedical engineering; materials science (all); 3003rheological studiesFlavonoidsInflammationWound Healing0104 chemical sciencesAnimals NewbornchemistryLiposomesBiophysicsNanoparticlesBaicalin
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Widening use of dexamethasone implant for the treatment of macular edema

2017

Vincenza Bonfiglio, Michele Reibaldi, Matteo Fallico, Andrea Russo, Alessandra Pizzo, Stefano Fichera, Carlo Rapisarda, Iacopo Macchi, Teresio Avitabile, Antonio Longo Department of Ophthalmology, University of Catania, Catania, Italy Abstract: Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis. The implant is formulated in a biodegradable copolymer to release the active ingredient within the vitreous chamber for up to 6 months after an intravitreal injection, allowing a prolonged interval of effica…

3003intravitrealgenetic structuresimplantmedicine.medical_treatmentPharmaceutical ScienceVitrectomyReviewDrug Implantcorticosteroids0302 clinical medicineGlucocorticoidCentral retinal vein occlusionDrug DiscoveryDelayed-Action PreparationCorticosteroidRandomized Controlled Trials as TopicDrug ImplantsCorticosteroids; Dexamethasone; Implant; Intravitreal; Macular edema; Pharmacology; 3003; Drug Discovery3003 Pharmaceutical ScienceDiabetic retinopathyIntravitreal InjectionsUveitismedicine.drugHumanmedicine.medical_specialtydexamethasone03 medical and health sciencesOphthalmologymedicineHumansMacular edemaGlucocorticoidsDexamethasonePharmacologyMacular edemaDiabetic Retinopathybusiness.industryIntravitreal InjectionDrug Discovery3003 Pharmaceutical Sciencelcsh:RM1-950Macular degenerationmedicine.diseaseeye diseasesSurgerylcsh:Therapeutics. PharmacologyDelayed-Action Preparations030221 ophthalmology & optometryBranch retinal vein occlusionsense organsbusiness030217 neurology & neurosurgeryDrug Design, Development and Therapy
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Gold nanostar–polymer hybrids for siRNA delivery: Polymer design towards colloidal stability and in vitro studies on breast cancer cells

2017

To overcome the low bioavailability of siRNA (small interfering RNA) and to improve their transfection efficiency, the use of non-viral delivery carriers is today a feasible approach to transform the discovery of these incredibly potent and versatile drugs into clinical practice. Polymer-modified gold nanoconstructs (AuNCs) are currently viewed as efficient and safe intracellular delivery carriers for siRNA, as they have the possibility to conjugate the ability to stably entrap and deliver siRNAs inside cells with the advantages of gold nanoparticles, which can act as theranostic agents and radiotherapy enhancers through laser-induced hyperthermia. In this study, AuNCs were prepared by coat…

3003siRNA deliverySmall interfering RNAPolymersMetal NanoparticlesPharmaceutical ScienceGold Colloid02 engineering and technologyPolyethylene Glycol01 natural sciencesPolyethylene GlycolsGold Colloidchemistry.chemical_compoundDrug Delivery SystemsMCF-7 CellDrug StabilityCoatingRNA Small InterferingPolymerDrug Carrierchemistry.chemical_classificationDrug CarriersTumorLipoic acidGold nanostarPolymer021001 nanoscience & nanotechnologyColloidal goldMCF-7 Cells0210 nano-technologyDrug carrierHydrophobic and Hydrophilic InteractionsBreast NeoplasmHumanBiological AvailabilityReproducibility of ResultBreast NeoplasmsNanotechnologyPolyethylene glycolengineering.materialSmall InterferingTransfection010402 general chemistryCell LineHydrophobic and Hydrophilic InteractionMetal NanoparticleCell Line TumorAmphiphileHumansGene SilencingParticle SizeGold nanostarsReproducibility of ResultsGold nanostars; Lipoic acid; MCF-7; PEG; PHEA; siRNA delivery; Biological Availability; Breast Neoplasms; Cell Line; Tumor; Drug Carriers; Drug Delivery Systems; Drug Stability; Gene Silencing; Gold; Gold Colloid; Humans; Hydrophobic and Hydrophilic Interactions; MCF-7 Cells; Metal Nanoparticles; Particle Size; Polyethylene Glycols; Polymers; RNA; Small Interfering; Reproducibility of Results; Transfection; 3003PHEAPEG0104 chemical scienceschemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoengineeringRNAGoldMCF-7Drug Delivery SystemInternational Journal of Pharmaceutics
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Multisensory texture exploration at the tip of the pen

2016

A tool for the multisensory stylus-based exploration of virtual textures was used to investigate how different feedback modalities (static or dynamically deformed images, vibration, sound) affect exploratory gestures. To this end, we ran an experiment where participants had to steer a path with the stylus through a curved corridor on the surface of a graphic tablet/display, and we measured steering time, dispersion of trajectories, and applied force. Despite the variety of subjective impressions elicited by the different feedback conditions, we found that only nonvisual feedback induced significant variations in trajectories and an increase in movement time. In a post-experiment, using a pa…

3304Computer scienceRealization (linguistics)ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISIONHuman Factors and ErgonomicsMultisensory Textures02 engineering and technologyTexture (music)Multisensory textureEducationEngineering (all)Sonic Interaction DesignSonic interaction design0202 electrical engineering electronic engineering information engineeringComputer visionEngineering(all)Pen-based interaction; Pseudo-haptics; Multisensory textures; Sonic interaction designPseudo-hapticComputingMethodologies_COMPUTERGRAPHICSSettore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniSettore INF/01 - Informaticabusiness.industryMovement (music)Work (physics)General Engineering020207 software engineeringMultisensory textures; Pen-based interaction; Pseudo-haptics; Sonic interaction design; Human Factors and Ergonomics; Software; 3304; Engineering (all); Human-Computer Interaction; Hardware and ArchitectureHuman Factors and ErgonomicPseudo-hapticsHuman-Computer InteractionPen-based InteractionHardware and Architecture020201 artificial intelligence & image processingArtificial intelligencebusinessStylusSoftwareGraphics tabletGesture
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Executive functions in kindergarten children at risk for developmental coordination disorder

2018

Executive functioning (EF) is a key cognitive process for development. Little is known about EF in Kindergarten children at risk for developmental coordination disorder (DCD), despite this age being one of the most critical and intensive period of motor and cognitive development. In our investigation we compared EF in kindergarten children at risk for DCD with Typically Developing (TD) children. Participants were 36 Italian children, 18 at risk for DCD (9 boys and 9 girls) who had a mean age of 4.6 years and 18 TD (9 boys and 9 girls) who had a mean age of 4.6. Executive functions were measured by tasks targeting cold executive functioning (working memory, fluency, inhibitory control) and t…

3304media_common.quotation_subjecteducationShort-term memoryDevelopmental Coordination Disorder; executive functioning; fluency; inhibitory Control; kindergarten; working memory; 3304; Health Professions (miscellaneous); Developmental and Educational PsychologyDevelopmental Coordination DisorderHealth Professions (miscellaneous)working memoryEducationDevelopmental psychologySettore M-PSI/04 - Psicologia Dello Sviluppo E Psicologia Dell'EducazioneDevelopmental and Educational Psychologykindergarten0501 psychology and cognitive sciencesfluencyAt-risk studentsmedia_commonPsychomotor learningWorking memory05 social sciences050301 educationCognitionSelf-controlinhibitory ControlExecutive functionsChild developmentPsychologyexecutive functioning0503 education050104 developmental & child psychologyEuropean Journal of Special Needs Education
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Thermomineral waters of Greece: geochemical characterization

2020

75 °C). In terms of pH most results vary from 5.5 to 823 °C) ii) warm (23 40 °C) iii) thermal (40 75 °C) and iv) hyperthermal (&gtfew springs show either very low pH (&lt10) proposing serpentinization processes. Regarding TDS concentrations collected waters can be subdivided into low salinity (up to 1.5 g/L) brackish (up to 20 g/L) and saline (up to 43 g/L). The medium high salinities can be justified by mixing with sea water and/or strong waterrock interaction processes. Isotope composition of O and H ranges from 12.7 to +2.7 ‰ SMOW and from 91 to +12 ‰ SMOW respectively and is generally comprised between the Global Meteoric Water Line and the East Mediterranean Meteoric Water Line. Only few water samples show a positive shift for δ18O possibly related to high temperature waterrock interaction processes. Carbon dioxide (18 997000 μmol/mol) or N2 (1100 989000 μmol/mol) or CH4 (&ltMany geothermal areas of Greece are located in regions affected by Miocene or Quaternary volcanism and in continental basins characterised by elevated heat flow. Moreover the majority of them is found along the coast as well as in islands of the Aegean Sea and thus thermal water is often brackish to saline due to marine intrusion into costal aquifer. In the present study almost 300 thermal and cold mineral water samples were collected along the Hellenic territory with their physicochemical parameters (temperature pH electrical conductivity and Eh) and the amount of bicarbonates (titration with 0.1N HCl) being determined in situ. Additionally gases found either in free or dissolved phase were sampled. Both water and gas samples were analysed at the INGVPa laboratories for major ions (Ion Chromatography) silica (Inductively Coupled Plasma Optical Emission Spectrometry) chemical composition of free and dissolved gases (Gas Chromatography) water isotopes (O and H) and carbon and helium isotopes of free and dissolved gases (Mass Spectrometry). The temperature of the investigated waters ranges from 6.5 to 98°C pH from 1.96 to 11.98 whilst Total Dissolved Solids (TDS) from 0.06 to 43 g/L. Based on the temperature parameter waters can be divided into four groups: i) cold (&lt0.5 913000 μmol/mol) are the prevailing gas species found in the studied sites. The δ13CCO2 values ranged from 20.1 to +8.5 ‰ whilst the isotope ratio of He from 0.21 to 6.71 R/RA.4) suggesting interaction with H2Srich gases or very high pH values (&gtSettore GEO/08 - Geochimica E Vulcanologia
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Responsabilidad civil médica y reproducción asistida: Dos casos de estudio

2018

El presente trabajo examina los aspectos más relevantes de la responsabilidad civil en materia de reproducción asistida y aborda el estudio de dos casos recientes de especial trascendencia.

:CIENCIAS JURÍDICAS [UNESCO]UNESCO::CIENCIAS JURÍDICASconsentimiento informado.informed consent. 310 329técnicas de reproducción asistidaLuis El presente trabajo examina los aspectos más relevantes de la responsabilidad civil en materia de reproducción asistida y aborda el estudio de dos casos recientes de especial trascendencia. Responsabilidad civilCivil liabilityassisted reproductive techniques2386-4567 22661 Actualidad jurídica iberoamericana 502169 2018 9 6653329 Responsabilidad civil médica y reproducción asistida: Dos casos de estudio de las Heras VivesDos casos de estudio de las Heras Vives [2386-4567 22661 Actualidad jurídica iberoamericana 502169 2018 9 6653329 Responsabilidad civil médica y reproducción asistida]
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Contenido de la carta individual de extinción en el marco del despido colectivo : Incidencia sobre la afectación de trabajadoras embarazadas

2021

La presente obra analiza los principales pronunciamientos judiciales en relación al contenido de la carta individual de despido derivado de un despido colectivo. Se discute sobre la conveniencia de incluir la causa en la carta, así como los criterios de selección del trabajador afectado. La cuestión tiene una especial incidencia sobre un colectivo concreto: las trabajadoras embarazadas.

:CIENCIAS JURÍDICAS [UNESCO]las trabajadoras embarazadas. Carta individual de despido [así como los criterios de selección del trabajador afectado. La cuestión tiene una especial incidencia sobre un colectivo concreto]collective dismissalspregnant workers. 390 421Individual extinction letterJuan Alberto La presente obra analiza los principales pronunciamientos judiciales en relación al contenido de la carta individual de despido derivado de un despido colectivo. Se discute sobre la conveniencia de incluir la causa en la cartaUNESCO::CIENCIAS JURÍDICAScriterios de selecciónasí como los criterios de selección del trabajador afectado. La cuestión tiene una especial incidencia sobre un colectivo concreto: las trabajadoras embarazadas. Carta individual de despidodespidos colectivostrabajadoras embarazadas.2070-8157 22082 Revista Boliviana de Derecho 565487 2021 31 7730063 Contenido de la carta individual de extinción en el marco del despido colectivo Incidencia sobre la afectación de trabajadoras embarazadas Tormos Pérezselection criteria
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La implicatura en los blogs educativos. Una aproximación pragmática

2015

[ES] La tecnología está multiplicando las formas en que podemos comunicarnos. Desde la aparición de Internet, la construcción del discurso, los géneros discursivos y el lenguaje mismo se han visto afectados por las características de este nuevo modo de comunicarse. Aparecen discursos mixtos que hacen necesarios nuevos enfoques. Así, el estudio de la red desde una perspectiva pragmática ha abarcado diferentes aproximaciones (el género, la caracterización del lenguaje de los textos, etc.); los blogs han sido considerados como una forma de conversación. El presente trabajo estudia los blogs educativos desde el punto de vista de las máximas conversacionales de Grice, y, en particular, las impli…

:CIENCIAS TECNOLÓGICAS [UNESCO]ImplicaturaEducational blogPragmaticsAnálisis de blogs y redes sociales para su aplicación en el aula y en la empresa 32078 / W - Programa de doctorado en lenguas y tecnología 2145EducaciónBlog educativoMáxima conversacionalUNESCO::CIENCIAS TECNOLÓGICASPragmáticaAnálisis de blogs y redes sociales para su aplicación en el aula y en la empresa 32078 / X - Máster universitario en lenguas y tecnología 2139FILOLOGIA INGLESACMCInternet y redes sociales en el aula 32078 / X - Máster universitario en lenguas y tecnología 2139Psicología y educaciónConversational maximInternet y redes sociales en el aula 32078 / W - Programa de doctorado en lenguas y tecnología 2145Implicature
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