Search results for " 46"
showing 10 items of 140 documents
The Poincar\'e-Cartan Form in Superfield Theory
2018
An intrinsic description of the Hamilton-Cartan formalism for first-order Berezinian variational problems determined by a submersion of supermanifolds is given. This is achieved by studying the associated higher-order graded variational problem through the Poincar\'e-Cartan form. Noether theorem and examples from superfield theory and supermechanics are also discussed.
Il divieto di "caccia all’errore" nelle gare, previsto dall’art. 46, comma 1 bis, del codice degli appalti.
2011
López García, José Miguel: La esclavitud a finales del antiguo régimen. Madrid, 1701-1837. De moros de presa a negros de nación
2020
Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmito…
2014
The Hedgehog (Hh) family of secreted proteins act as morphogens to control embryonic patterning and development in a variety of organ systems. Post-translational covalent attachment of cholesterol and palmitate to Hh proteins are critical for multimerization and long range signaling potency. However, the biological impact of lipid modifications on Hh ligand distribution and signal reception in humans remains unclear. In the present study, we report a unique case of autosomal recessive syndromic 46,XY Disorder of Sex Development (DSD) with testicular dysgenesis and chondrodysplasia resulting from a homozygous G287V missense mutation in the hedgehog acyl-transferase (HHAT) gene. This mutation…
Chronic social defeat stress causes retinal vascular dysfunction
2021
Abstract Purpose The roles of vascular dysfunction and chronic stress have been extensively discussed in the pathophysiology of glaucoma. Our aim was to test whether chronic stress causes retinal vascular dysfunction and therewith induces retinal ganglion cells (RGCs) loss. Methods Twelve mice underwent chronic social defeat (CSD) stress, while 12 mice received control treatment only. Intraocular pressure (IOP) was measured with a rebound tonometer. Blood plasma corticosterone concentration and adrenal gland weight were used to assess stress levels. Brn-3a staining in retinas and PPD staining in optic nerve cross sections were conducted to assess the survival of RGCs and axons respectively.…
Activation of a ΔFOSB dependent gene expression pattern in the dorsolateral prefrontal cortex of patients with major depressive disorder
2010
Abstract Background A ΔFOSB mediated transcriptional response in the nucleus accumbens (NAc) is induced by chronic social stress in rodent and a 50% down-regulation of ΔFOSB has been also reported in the NAc of eight depressed subjects. To evaluate the role of ΔFOSB in the prefrontal cortex which is critically involved in negative cognitive bias associated with major depressive disorder (MDD) we have quantified the mRNA levels of ΔFOSB and of five of its major target genes in the Brodmann area 46 from 24 patients with MDD (11 with psychotic symptoms) and 12 controls. Method Expression of the six genes has been quantified by a real-time quantitative PCR method: ΔFOSB , GRIA2 (encoding the Gl…
Los corregidores de Betanzos en la segunda mitad del siglo XVIII (1748-1808): análisis social y profesional
2020
El objetivo de este trabajo consiste en estudiar la vertiente social del poder, analizando para ello la trayectoria de quienes ocuparon el corregimiento de Betanzos desde su creación, a mediados del siglo XVIII, hasta que el estallido de la guerra de la Independencia, en 1808, empezó a alterar la, hasta ese momento, estable división administrativa del reino. Origen geográfico, estudios cursados, vínculos familiares o trayectoria profesional serán algunos de los aspectos a analizar, como también la actuación desarrollada por quienes ostentaron la titularidad del corregimiento. The objective of this work is to study the social side of power, analyzing for it the trajectory of those who occupi…
Higher integrability and stability of (p,q)-quasiminimizers
2023
Using purely variational methods, we prove local and global higher integrability results for upper gradients of quasiminimizers of a $(p,q)$-Dirichlet integral with fixed boundary data, assuming it belongs to a slightly better Newtonian space. We also obtain a stability property with respect to the varying exponents $p$ and $q$. The setting is a doubling metric measure space supporting a Poincar\'e inequality.
Volume growth, capacity estimates, p-parabolicity and sharp integrability properties of p-harmonic Green functions
2023
In a complete metric space equipped with a doubling measure supporting a $p$-Poincar\'e inequality, we prove sharp growth and integrability results for $p$-harmonic Green functions and their minimal $p$-weak upper gradients. We show that these properties are determined by the growth of the underlying measure near the singularity. Corresponding results are obtained also for more general $p$-harmonic functions with poles, as well as for singular solutions of elliptic differential equations in divergence form on weighted $\mathbf{R}^n$ and on manifolds. The proofs are based on a new general capacity estimate for annuli, which implies precise pointwise estimates for $p$-harmonic Green functions…
Loomis-Whitney inequalities in Heisenberg groups
2021
This note concerns Loomis-Whitney inequalities in Heisenberg groups $\mathbb{H}^n$: $$|K| \lesssim \prod_{j=1}^{2n}|\pi_j(K)|^{\frac{n+1}{n(2n+1)}}, \qquad K \subset \mathbb{H}^n.$$ Here $\pi_{j}$, $j=1,\ldots,2n$, are the vertical Heisenberg projections to the hyperplanes $\{x_j=0\}$, respectively, and $|\cdot|$ refers to a natural Haar measure on either $\mathbb{H}^n$, or one of the hyperplanes. The Loomis-Whitney inequality in the first Heisenberg group $\mathbb{H}^1$ is a direct consequence of known $L^p$ improving properties of the standard Radon transform in $\mathbb{R}^2$. In this note, we show how the Loomis-Whitney inequalities in higher dimensional Heisenberg groups can be deduced…