Search results for " 4"

showing 10 items of 3131 documents

PEG 400/Cerium Ammonium Nitrate Combined with Microwave-Assisted Synthesis for Rapid Access to Beta-Amino Ketones. An Easy-to-Use Protocol for Discov…

2018

Compound libraries are important requirement in target-based drug discovery. In the present work, a small focused compound library based on β-aminoketone scaffold has been prepared combining microwave-assisted organic synthesis (MAOS) with polymer-assisted solution phase synthesis (PASPS) and replacing reaction workup standard purification procedures with solid phase extraction (SPE). Specifically, the effects of solvent, such as dioxane, dimethylformamide (DMF), polyethylene glycol 400 (PEG 400), temperature, irradiation time, stoichiometric ratio of reagents, and catalysts (HCl, acetic acid, cerium ammonium nitrate (CAN)) were investigated to maximize both conversion and yield. The optimi…

3003Transcription FactorPharmaceutical ScienceNitratePolyethylene Glycol01 natural sciencesPolyethylene GlycolsPolymer-assisted solution phase synthesiAnalytical Chemistrychemistry.chemical_compoundDrug DiscoveryMannich reactionSolid phase extractionMicrowavesβ-aminoketonesCeriumKetonesKetoneDNA-Binding ProteinsSolventCeriumChemistry (miscellaneous)Molecular MedicineDimethylformamideMicrowave-assisted organic synthesiMannich reaction; β-aminoketones; microwave-assisted organic synthesis; polymer-assisted solution phase synthesis; solid phase extraction; drug discoveryDNA-Binding ProteinBacterial Proteinchemistry.chemical_elementPolyethylene glycol010402 general chemistryArticlelcsh:QD241-441Bacterial Proteinslcsh:Organic chemistryΒ-aminoketonePhysical and Theoretical ChemistrySolid phase extractionpolymer-assisted solution phase synthesisPEG 400Nitrates010405 organic chemistryDrug Discovery3003 Pharmaceutical ScienceOrganic ChemistrySettore CHIM/08 - Chimica FarmaceuticaCombinatorial chemistry0104 chemical scienceschemistryYield (chemistry)microwave-assisted organic synthesisOrganic synthesisMicrowaveTranscription FactorsMolecules
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Isometric embeddings of snowflakes into finite-dimensional Banach spaces

2016

We consider a general notion of snowflake of a metric space by composing the distance by a nontrivial concave function. We prove that a snowflake of a metric space $X$ isometrically embeds into some finite-dimensional normed space if and only if $X$ is finite. In the case of power functions we give a uniform bound on the cardinality of $X$ depending only on the power exponent and the dimension of the vector space.

30L05 46B85 54C25 54E40 28A80Pure mathematicsmetric spacesGeneral MathematicsMathematicsofComputing_GENERALBanach space01 natural sciencesfunctional analysisCardinalityMathematics - Metric GeometryDimension (vector space)0103 physical sciencesFOS: MathematicsMathematics (all)Mathematics::Metric Geometry0101 mathematicsSnowflakeNormed vector spaceMathematicsConcave functionApplied Mathematicsta111010102 general mathematicsnormiavaruudetMetric Geometry (math.MG)normed spacesmetriset avaruudetMetric spacefractalsfraktaalit010307 mathematical physicsfunktionaalianalyysiMathematics (all); Applied MathematicsVector spaceProceedings of the American Mathematical Society
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Entre l’État et la chefferie simple : le complexe aristocratique de Vix/le mont Lassois

2021

International audience

390 Customs etiquette & folklore930 History of ancient world (to ca. 499)[SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and PrehistoryPrincipauté celtique390 Customs etiquette & folkloreVix-mont LassoisComputingMilieux_MISCELLANEOUS
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CCDC 777752: Experimental Crystal Structure Determination

2011

Related Article: Yuhui Kou, Hongqi Tao, Derong Cao, Zhiyong Fu, D.Schollmeyer, H.Meier|2010|Eur.J.Org.Chem.|2010|6464|doi:10.1002/ejoc.201000718

49141926-Pentabutoxy-2428303234-pentamethoxyhexacyclo[21.2.2.2^36^.2^811^.2^1316^.2^1821^]pentatriaconta-1(25)358101315182023262830323 4-pentadecaenebis(acetonitrile) clathrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Ionic liquid crystals based on viologen dimers: tuning the mesomorphism by varying the conformational freedom of the ionic layer

2016

ABSTRACTWe investigated the liquid crystal behaviour of newly synthesised bistriflimide salts of symmetric viologen dimers. A smectic A phase was observed for intermediate spacer lengths and for relatively long lateral alkyl chains. The systems were characterised by thermal analysis, polarised optical microscopy, X-ray scattering and solid-state NMR. An intermediate ordered smectic phase was also exhibited by the compounds (except for systems with very short lateral chains) consisting of molten layers of alkyl chains and partially ordered ionic layers. These results, relating to the mesomorphic behaviour of viologen salts, are qualitatively compared to those of the more common imidazolium s…

4-4?-bipyridinium4-4ʹ-bipyridiniumMaterials scienceIonic liquid crystals; viologens; 4-4ʹ-bipyridiniumIonic bonding02 engineering and technology010402 general chemistry01 natural scienceschemistry.chemical_compoundLiquid crystalPhase (matter)medicineOrganic chemistryGeneral Materials ScienceBistriflimideviologensAlkylSettore CHIM/02 - Chimica Fisicachemistry.chemical_classificationviologenChemistry (all)MesophaseViologenGeneral ChemistrySettore CHIM/06 - Chimica Organica4-4ʹ-bipyridinium; Ionic liquid crystals; viologens; Condensed Matter Physics; Materials Science (all); Chemistry (all)021001 nanoscience & nanotechnologyCondensed Matter Physics0104 chemical sciencesCrystallographychemistryIonic liquidIonic liquid crystalsIonic liquid crystalMaterials Science (all)0210 nano-technologymedicine.drug
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CCDC 1849905: Experimental Crystal Structure Determination

2018

Related Article: A. Piontek, D. Siodłak, B. Zarychta|2018|IUCrData|3|x180889|doi:10.1107/S2414314618008891

4-chloronaphthalen-1-yl 4-methylbenzene-1-sulfonateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Isoxazolo[5,4-e]isoindole a new ring system with potent antitumor activity

2011

4-e]isoindoleIsoxazolo[5; 4-e]isoindole; Combretastatin; antitumor agentsCombretastatinIsoxazolo[5antitumor agentsIsoxazolo[54-e]isoindole Combretastatin antitumor agents
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Better numerical approximation by Durrmeyer type operators

2018

The main object of this paper is to construct new Durrmeyer type operators which have better features than the classical one. Some results concerning the rate of convergence and asymptotic formulas of the new operator are given. Finally, the theoretical results are analyzed by numerical examples.

41A25 41A36Applied Mathematics010102 general mathematicsConstruct (python library)Numerical Analysis (math.NA)Type (model theory)Object (computer science)01 natural sciences010101 applied mathematicsMathematics (miscellaneous)Operator (computer programming)Rate of convergenceNumerical approximationFOS: MathematicsApplied mathematicsMathematics - Numerical Analysis0101 mathematicsMathematics
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Estimates for the differences of positive linear operators and their derivatives

2019

The present paper deals with the estimate of the differences of certain positive linear operators and their derivatives. Oxur approach involves operators defined on bounded intervals, as Bernstein operators, Kantorovich operators, genuine Bernstein-Durrmeyer operators, and Durrmeyer operators with Jacobi weights. The estimates in quantitative form are given in terms of the first modulus of continuity. In order to analyze the theoretical results in the last section, we consider some numerical examples.

41A25 41A36Applied MathematicsNumerical analysisLinear operatorsNumerical Analysis (math.NA)010103 numerical & computational mathematics01 natural sciencesModulus of continuity010101 applied mathematicsSection (fiber bundle)Mathematics - Classical Analysis and ODEsBounded functionTheory of computationClassical Analysis and ODEs (math.CA)FOS: MathematicsOrder (group theory)Applied mathematicsMathematics - Numerical Analysis0101 mathematicsAlgebra over a fieldMathematics
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Better approximation of functions by genuine Bernstein-Durrmeyer type operators

2018

The main object of this paper is to construct a new genuine Bernstein-Durrmeyer type operators which have better features than the classical one. Some direct estimates for the modified genuine Bernstein-Durrmeyer operator by means of the first and second modulus of continuity are given. An asymptotic formula for the new operator is proved. Finally, some numerical examples with illustrative graphics have been added to validate the theoretical results and also compare the rate of convergence.

41A25 41A36FOS: MathematicsNumerical Analysis (math.NA)Mathematics - Numerical Analysis
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