Search results for " ACE"
showing 10 items of 1883 documents
HDlive imaging of cystic uterine leiomyoma degeneration
2016
The histone acetyltransferase MOF activates hypothalamic polysialylation to prevent diet-induced obesity in mice
2014
Overfeeding causes rapid synaptic remodeling in hypothalamus feeding circuits. Polysialylation of cell surface molecules is a key step in this neuronal rewiring and allows normalization of food intake. Here we examined the role of hypothalamic polysialylation in the long-term maintenance of body weight, and deciphered the molecular sequence underlying its nutritional regulation. We found that upon high fat diet (HFD), reduced hypothalamic polysialylation exacerbated the diet-induced obese phenotype in mice. Upon HFD, the histone acetyltransferase MOF was rapidly recruited on the St8sia4 polysialyltransferase-encoding gene. Mof silencing in the mediobasal hypothalamus of adult mice prevented…
CCDC 874635: Experimental Crystal Structure Determination
2013
Related Article: K.Mack, A.W.von Leupoldt, C.Forster, M.Ezhevskaya, D.Hinderberger, K.W.Klinkhammer, K.Heinze|2012|Inorg.Chem.|51|7851|doi:10.1021/ic300929g
CCDC 874634: Experimental Crystal Structure Determination
2013
Related Article: K.Mack, A.W.von Leupoldt, C.Forster, M.Ezhevskaya, D.Hinderberger, K.W.Klinkhammer, K.Heinze|2012|Inorg.Chem.|51|7851|doi:10.1021/ic300929g
Entornos virtuales de aprendizaje: modelo ampliado de aceptación de la tecnología
2019
Dentro de la actual renovación de las metodologías docentes, las universidades están impulsando el uso de entornos virtuales de aprendizaje como una herramienta básica en la enseñanza presencial, ya que permite flexibilizar e individualizar la educación. El objetivo del presente trabajo es aportar evidencia empírica sobre la percepción que tienen los alumnos respecto a la mejora en su aprendizaje, al adoptar y utilizar entornos virtuales en la enseñanza presencial, a partir del Modelo de Aceptación de la Tecnología ampliado. La población objeto del estudio son 251 casos de estudiantes de primer grado de la Facultad de Economía de la Universitat de Valencia. Se ha evidenciado empíricamente, …
Propuesta de un modelo integrador de las actitudes, procesamiento y eficacia de la publicidad móvil
2015
En la presente Tesis Doctoral se aborda el estudio del procesamiento y eficacia de la publicidad móvil analizando sus principales antecedentes e integrando distintas disciplinas y marcos teóricos, principalmente los siguientes: la Teoría de Difusión de las Innovaciones, los Modelos explicativos de Actitudes, el Marketing de Permiso y el Modelo de Jerarquía de Efectos de Batra y Ray. En la Tesis Doctoral se plantea que la actitud del individuo hacia el anuncio móvil es el elemento fundamental de unión entre variables intrínsecas del comportamiento, el procesamiento de los contenidos publicitarios y su eficacia (actitudes y decisión de compra de las marcas anunciadas a través de dispositivos …
Progestogens and risk of breast cancer: a link between bone and breast?
2015
This article reviews the data supporting the role of receptor activator of the nuclear factor kappa (RANK) and its ligand, RANKL, in progestogen-induced breast cancer. Both experimental and clinical studies have been included. The expression of both RANK and RANKL has been described in epithelial cells of both mice and humans. Experiments of gain and loss of function in mice have shown that RANK/RANKL mediate alveologenesis during pregnancy or the estrous cycle. Moreover, the participation of the RANK/RANKL has been detected in models of breast carcinogenesis associated with progestogens-like medroxyprogesterone acetate. Recent clinical studies have found that the expression of RANK is asso…
A ten-year follow-up of the Reflection cementless acetabular component.
2008
We reviewed the long-term results at ten to 12 years of 118 total hip replacements in 109 patients using a second-generation hemispherical cementless acetabular component (Reflection) designed to address the problem of backside wear. Five patients (five hips) died and six patients (seven hips) were lost to follow-up. The remaining 98 patients (106 hips) had a mean age of 62.9 years (34.0 to 86.2) A rate of revision for aseptic loosening of 0.9%, and predictable results were found with respect to radiological evidence of fixation, lack of pain, walking ability, range of movement and function. One component was revised for aseptic loosening, and of the 101 hips (95.2%) that did not have a rev…
Intra-articular corticosteroids versus intra-articular corticosteroids plus methotrexate in oligoarticular juvenile idiopathic arthritis: a multicent…
2017
Summary Background Little evidence-based information is available to guide the treatment of oligoarticular juvenile idiopathic arthritis. We aimed to investigate whether oral methotrexate increases the efficacy of intra-articular corticosteroid therapy. Methods We did this prospective, open-label, randomised trial at ten hospitals in Italy. Using a concealed computer-generated list, children younger than 18 years with oligoarticular-onset disease were randomly assigned (1:1) to intra-articular corticosteroids alone or in combination with oral methotrexate (15 mg/m 2 ; maximum 20 mg). Corticosteroids used were triamcinolone hexacetonide (shoulder, elbow, wrist, knee, and tibiotalar joints) o…
Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex
2014
Highlights • We characterise Sas3p and Gcn5p active HAT complexes in WT and deleted TAP-strains. • We confirm that Pdp3p interacts with NuA3, histones and chromatin regulators. • Pdp3p MS-analysis reveals its phosphorylation, ubiquitination and methylation. • Sas3p can substitute Gcn5p in acetylation of histone H3K14 but not of H3K9. • Genome-wide profiling of Sas3p supports its involvement in transcriptional elongation.