Search results for " ADR"
showing 10 items of 285 documents
Cross-listing, price discovery and the informativeness of the trading process
2003
This paper analyzes the price discovery process of securities that trade at multiple markets with trading sessions that totally or partially overlap. Building on Hasbrouck (1995) information share approach, we introduce a methodology that distinguishes two sources of information asymmetries between markets: trade-related and trade-unrelated informative shocks. This approach determines how much of each market?s relative contribution to the price discovery process during the overlapping period is attributable to its own trading activity. We provide empirical evidence on the contribution of the NYSE in the price discovery process of the Spanish cross-listed stocks during the daily two-hour ove…
Uzlabotā Eiropas Savienības ekonomikas pārvaldība un tās ietekme uz strukturālo reformu ieviešanu Latvijā
2019
Pēc ekonomiskās un finanšu krīzes perioda strukturālo reformu ieviešanas intensitāte Latvijā ir samazinājusies. Strukturālo reformu ieviešanai ir nozīmīga loma Latvijas tautsaimniecības attīstībā un reformu dzinulis bijis vitāli nepieciešams ātrākai izaugsmei. Maģistra darba mērķis un uzdevumi ir analizēt Eiropas semestra ietekmi uz strukturālo reformu ieviešanu Latvijā. Maģistra darba ietvaros ir analizēti Eiropas Komisijas sagatavotie ziņojumi par Latviju, Latvijai sniegtās rekomendācijas, to ieviešanas progress, kā arī veiktas intervijas ar Eiropas semestra koordinācijas procesā iesaistītajām personām. Iegūtie rezultāti liecina, ka Eiropas semestra ietvaros Latvijai sniegto rekomendāciju…
Fercolo del SS. Crocifisso
2010
Synthesis and preliminary evaluation of (R,R)(S,S) 5-(2-(2-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylethylamino)-1-hydroxyethyl)-benzene-1,3-diol ([18F…
2003
The 18 F-labeled b2-adrenergic receptor ligand (R,R)(S,S) 5-(2-(2-(4-(2-( 18 F)fluoroethoxy)phenyl)-1-methylethylamino)-1- hydroxyethyl)-benzene-1,3-diol, a derivative of the original highly selective racemic fenoterol, was synthesized in an overall radio- chemical yield of 20% after 65 min with a radiochemical purity higher than 98%. The specific activity was in the range of 50-60 GBq/mmol. In vitro testing of the non-radioactive fluorinated fenoterol derivative with isolated guinea pig trachea was conducted to obtain an IC50 value of 60 nM. Preliminary ex vivo organ distribution and in vivo experiments with positron emission tomography (PET) on guinea pigs were performed to study the biod…
In guerra senza il nemico. Die Katrin wird Soldat di Adrienne Thomas
2015
Negli anni che vanno dalla guerra franco-prussiana all'avvento del fascismo in Italia, la costruzione ideologica dell’immaginario nazionalistico e del discorso identitario in Europa si fa pervasiva e totalizzante, investendo gli ambiti tradizionali della letteratura, delle arti figurative, del discorso politico e filosofico e modellando il dibattito pubblico, le nuove forme di espressione artistica, no a caratterizzare alcuni movimenti d’avanguardia. Esito catastrofico di questa duplice «estetizzazione della politica» e «politicizzazione dell’estetica», per dirla con Walter Benjamin, è il primo confliitto mondiale, che costituisce il principale riferimento tematico di questo volume,…
Editorial Comment from Dr Michel to Expression and functional role of β3-adrenoceptors in the human ureter
2013
Myocardial G Protein Receptor–Coupled Kinase Expression Correlates With Functional Parameters and Clinical Severity in Advanced Heart Failure
2010
In heart failure (HF), sympathetic hyperactivation induces deleterious effects in myocardial β-adrenergic signaling, with receptor down-regulation and desensitization mediated by G protein receptor-coupled kinases (GRKs). We hypothesised that changes in GRK isoforms may be associated with clinical status in advanced HF, using the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) scale.We included 31 patients with advanced HF undergoing transplantation. According to INTERMACS profiles, mRNA and protein levels of GRK isoforms in left ventricular (LV) myocardium were analyzed and compared with nonfailing LV samples.In failing LV myocardium, GRK2 and GRK5 (but not G…
β2- and β1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases.
2015
To explore if genic expression of β(1)- or β(2)-adrenoceptors (ARs) exhibits a common regulatory pattern with G protein-coupled receptor kinase (GRK) 2, GRK3, or GRK5 expression, we determined messenger RNA levels for these genes in different tissues from human and animal models of cardiovascular disease. We measured genic expression by qRT polymerase chain reaction in the left and right ventricles or peripheral blood mononuclear cells from healthy (n = 21), hypertensive (n = 20), heart failure (n = 24), and heart transplanted patients (n = 17) or in left ventricle, peripheral blood mononuclear cells, and kidney from spontaneously hypertensive rats or L-N-methyl-arginine-induced hypertensiv…
Istutuspäällikkö Gaddin julkiset matkaraportit 1763–1765
2022
Artikkelissa tarkastellaan Inrikes Tidningarissa julkaistuja raportteja Pehr Adrian Gaddin (1727–1797) matkoista Suomessa vuosina 1763–1765. Tekstit sekä rikastavat käsitystä Gaddin toiminnasta istutuspäällikkönä että antavat esimerkin mahdollisesta julkisuuden käytöstä vapaudenajan lopun Ruotsissa.
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice
2002
The serine-threonine kinase Akt seems to be central in mediating stimuli from different classes of receptors. In fact, both IGF-1 and IL6-like cytokines induce hypertrophic and antiapoptotic signals in cardiomyocytes through PI3K-dependent Akt activation. More recently, it was shown that Akt is involved also in the hypertrophic and antiapoptotic effects of β-adrenergic stimulation. Thus, to determine the effects of Akt on cardiac function in vivo, we generated a model of cardiac-specific Akt overexpression in mice. Transgenic mice were generated by using the E40K, constitutively active mutant of Akt linked to the rat α-myosin heavy chain promoter. The effects of cardiac-selective Akt overex…