Search results for " AGI"
showing 10 items of 672 documents
Tackling frailty and functional decline: Background of the action group A3 of the European innovation partnership for active and healthy ageing
2018
Ageing populations represent a challenge to the sustainability of current healthcare systems. The need to balance these demographic changes with gains in healthy life years and quality of life (QoL) constitutes an additional challenge. Aware of this, the European Commission (EC) launched the European Innovation Partnership on Active and Healthy Ageing (EIPonAHA) in 2012. The EIPonAHA is an interdisciplinary and cross-sector initiative involving more than 3000 partners with two specific objectives: to increase the healthy life expectancy of Europeans by two years by 2020, while increasing their QoL. The initiatives of the EIPonAHA have been organized according to six thematic action groups (…
Life-long spontaneous exercise does not prolong lifespan but improves health span in mice
2013
Abstract Background Life expectancy at birth in the first world has increased from 35 years at the beginning of the 20th century to more than 80 years now. The increase in life expectancy has resulted in an increase in age-related diseases and larger numbers of frail and dependent people. The aim of our study was to determine whether life-long spontaneous aerobic exercise affects lifespan and healthspan in mice. Results Male C57Bl/6J mice, individually caged, were randomly assigned to one of two groups: sedentary (n = 72) or spontaneous wheel-runners (n = 72). We evaluated longevity and several health parameters including grip strength, motor coordination, exercise capacity (VO2max) and ske…
Aging and Cell Aging: An Introduction
2013
Since more than 100 years people are constantly growing older and a further significant increase in life time is expected in the decades to come. A person born today has a high statistical chance to reach the age of 100, to become a centenarian. Since aging is the primary risk factor for many human disorders it is mandatory to understand the aging process and how it affects onset and course of disorders of the elderly. Scientifically the medium life span is discriminated from the maximum life span. While the latter is rather constant at approximately 120 years the medium life span is increasing. But not only the whole organism, also each single cell out of the billions making up our body ha…
Adverse Clinical Events and Mortality During Hospitalization and 3 Months After Discharge in Cognitively Impaired Elderly Patients
2012
BACKGROUND: Controversial findings are reported on hospital outcome in cognitively impaired patients. The aim of this study was to explore mortality risk according to cognitive status during hospitalization and after 3 months in elderly patients. METHODS: Sixty-six internal medicine and geriatric wards in Italy participated in the "Registry Politerapie SIMI (REPOSI)" during 2010. Of the 1,380 in-patients, aged 65 and older enrolled, 1,201 were included. Cognition was evaluated with the Short Blessed Test (SBT). Logistic regression was used to evaluate the association of questionable and impaired cognition (according to SBT cutoff points) with mortality during hospitalization and at follow-u…
Oxidative stress is associated with an increased antioxidant defense in elderly subjects: a multilevel approach.
2014
© 2014 Fonseca et al. Background: Studies of associations between plasma GSH-Px activity and cardiovascular risk factors have been done in humans, and contradictory results have been reported. The aim of our study was to assess the association between the scavenger antioxidant enzyme glutathione peroxidase (GSH-Px) activity in plasma and the presence of novel and classical cardiovascular risk factors in elderly patients. Copyright: Methods: We performed a cross-sectional study with baseline data from a subsample of the PREDIMED (PREvención con DIeta MEDiterránea) study in Spain. Participants were 1,060 asymptomatic subjects at high risk for cardiovascular disease (CVD), aged 55 to 80, selec…
Successful aging: The role of cognitive gerontology
2017
International audience; This commentary explores the relationships between the construct of successful aging and the experimental psychology of human aging—cognitive gerontology. What can or should cognitive gerontology contribute to understanding, defining, and assessing successful aging? Standards for successful aging reflect value judgments that are culturally and historically situated. Fundamentally, they address social policy; they are prescriptive. If individuals or groups are deemed to be aging successfully, then their characteristics or situations can be emulated. If an individual or a group is deemed to be aging unsuccessfully, then intervention should be considered. Although scien…
Motives to practice exercise in old age and successful aging: A latent class analysis.
2018
Abstract Purpose The aim was to classify motives for exercising trying to find sets of related cases that share common motivations, and to relate these latent classes to markers of successful aging. Methods 725 old adult aged 55 to 97 years were sampled in several Spanish towns. Instruments: Successful Aging Inventory (SAI), International Physical Activity Questionnaire (IPAQ), Health Survey SF-8, Satisfaction with Life Scale (SWLS), and motives to practice exercise, were used. Latent Class Analyses (LCAs) were estimated. The classes obtained were compared on markers of successful aging. Results Three latent classes were deemed optimal. Significant differences for several markers of success…
Age identification in the framework of successful aging. A study of older Finnish people.
2003
A person-oriented approach was used in a study of age identification among community-dwelling older people. The study was based on 8-year follow-up data; 843 persons aged 65–84 were involved in the first phase of the study, and 426 persons aged 73–92, in the second phase. Loosely, on the basis of the distinction between successful, usual, and pathological aging (Rowe & Kahn, 1987, 1997), participants were grouped according to their self-ratings of cognitive and physical functioning as “Positive,” “Negative,” and “Others.” Participants possessing at least 4 out of the 5 criteria used as indicators of successful aging in the study (no illness or injury presenting problems in daily life, …
Role of prothrombotic polymorphisms in successful or unsuccessful aging.
2011
The study of the genetic profile of centenarians aims to identify the genes and allelic variants which may influence a greater life expectancy and that can be considered as predisposing factors associated to the aging diseases, such as Alzheimer. Centenarians, that represent a cohort of selected survivors, show an hypercoagulability state characterised by striking signs of high coagulation enzyme activity, as directly assessed by the tested higher plasma level of some important factors involved in the haemostasis balance. Anyway, these individuals seem to have a reduced susceptibility to dementia, as well as to cardiovascular events. In this study we analyze the frequencies of Leiden Factor…
Nutritional screening of older home-dwelling Norwegians: a comparison between two instruments.
2012
Ulrika Söderhamn, Bjørg Dale, Kari Sundsli, Olle SöderhamnCentre for Caring Research-Southern Norway, Faculty of Health and Sport Sciences, University of Agder, Grimstad, NorwayBackground: It is important to obtain knowledge about the prevalence of nutritional risk and associated factors among older home-dwelling people in order to be able to meet nutritional challenges in this group in the future and to plan appropriate interventions. The aim of this survey was to investigate the prevalence of home-dwelling older people at nutritional risk and to identify associated factors using two different nutritional screening instruments as self-report instruments.Methods…