Search results for " AGI"

Age and immunity

2006

Abstract Longitudinal studies are defining progressive alterations to the immune system associated with increased mortality in the very elderly. Many of these changes are exacerbated by or even caused by chronic T cell stimulation by persistent antigen, particularly from Cytomegalovirus. The composition of T cell subsets, their functional integrity and representation in the repertoire are all markedly influenced by age and by CMV. How these findings relate to epidemiological, functional, genetic, genomic and proteomic studies of human T cell immunosenescence was the subject of intense debate at an international conference held just before Christmas 2005 in the Black Forest.

Role of persistent CMV infection in configuring T cell immunity in the elderly

2007

Abstract Ageing is associated with declines in many physiological parameters, including multiple immune system functions. The rate of acceleration of the frequency of death due to cardiovascular disease or cancer seems to increase with age from middle age up to around 80 years, plateauing thereafter. Mortality due to infectious disease, however, does not plateau, but continues to accelerate indefinitely. The elderly commonly possess oligoclonal expansions of T cells, especially of CD8 cells, which, surprisingly, are often associated with cytomegalovirus (CMV) seropositivity. This in turn is associated with many of the same phenotypic and functional alterations to T cell immunity that have b…

Healthy Aging and Dietary Patterns

2021

A number of factors contribute to the complex process of aging, which finally define whether someone will or not develop age-associated chronic diseases in late life. These determinants comprise genetic susceptibility as well as various behavioral, environmental, and dietary factors, all of which have been shown to influence specific pathways regulating the aging process and the extension of life, which makes longevity a multidimensional phenomenon. Although a “miraculous elixir” or a “nutrition pill” are not plausible, researchers agree on the notion that nutritional factors have major impact on the risk of age-associated chronic non-communicable diseases and mortality. In recent years nut…

Agile Enterprise Transformations : Surveying the Many Facets of Agility for the Hybrid Era

2022

Agile companies are not uniform. Consequently, agile transformations are conceived broadly, ranging from adopting agile methods and practices in software development teams or functions to building all-encompassing enterprise agility. Moreover, the targeted effects of agility may vary, and the success of transformations and the attainment of agility are measured in various ways. In this paper, based on a recent industrial survey study, we scrutinize holistically why companies want to transform, what types of agility they are aiming at, and how they gauge transformations. The survey data was collected during the COVID-19 pandemic in 2020. Most of the respondents were in large or very large co…

Eurobarometer 51.0: The Elderly and Domestic Violence, March-May 1999

2000

This round of Eurobarometer surveys queried respondents on standard Eurobarometer measures, such as whether they attempted to persuade others close to them to share their views on subjects they held strong opinions about, whether they discussed political matters, and what the goals of the European Union (EU) should be. Additional questions focused on the respondents' knowledge of and opinions on the EU, including how well-informed they felt about the EU, what sources of information about the EU they used, and whether their country had benefited from being an EU member. Another major focus of the surveys was elderly people and domestic violence. Respondents were asked whether retired people …

MAGNESIUM IN AGING

2011

Magnesium and aging.

2009

Over the past decades, the clinical relevance and biological significance of magnesium (Mg) have been documented. Deficiency in Mg, aside from having a negative impact on the energy production pathway required by mitochondria to generate ATP, also reduces the threshold antioxidant capacity of the aging organism and its resistance to free-radical damage. Mg also acts as an antioxidant against free radical damage of the mitochondria. Chronic inflammation and oxidative stress have both been identified as pathogenic factors in aging and in several age-related diseases. Chronic Mg deficiency results in excessive production of oxygen-derived free radicals and low grade inflammation. Aging is very…

Magnesium and Health

2019

Magnesium (Mg) is the second most abundant cation after potassium in the intracellular compartment and has a critical role in modulating a large variety of cellular activities and metabolic pathways. Mg is cofactor in over 300 enzymatic reactions including all reactions that involve ATP utilization and transfer [1,2]. Over the past decades, the clinical relevance of Mg and its impact on health has been documented. In the human body, around 24 grams (1 mole) of Mg are present. Less than 1% of total Mg is in the serum; normal serum Mg concentrations range between 0.75-0.95 mmol/L (1.7-2.5 mg/dL or 1.5-1.9 meq/L). In healthy adults, daily Mg requirement is around 300-400 mg (5 to 6 mg/kg/day) …

Selected theories of ageing organisms

2016

Starzenie się jest złożonym procesem biologicznym, którego mechanizmy nie do końca są znane. Istnieje wiele teorii dotyczących mechanizmów tego procesu. W pracy opisano cztery teorie, które poruszają molekularny aspekt starzenia się organizmów. Jest to teoria telomerowa zakładająca wpływ długości telomerów na długość życia. Telomery to zlokalizowane na końcach chromosomów struktury nukleoproteinowe, chroniące przed utratą informacji genetycznej, ulegające skróceniu z każdym cyklem komórkowym. Nadmiernie skrócone telomery sprzyjają powstawaniu nowotworów, starzeniu się komórki i organizmów. Teoria mitochondrialna mówi o wpływie kumulujących się mutacji w mtDNA na procesy starzenia. Według ni…

Data from: Life history differences in age-dependent expressions of multiple ornaments and behaviors in a lekking bird

2014

Age is a major factor explaining variation in life-history traits among individuals with typical patterns of increasing trait values early in life, maximum trait expression, and senescence. However, age-dependent variation in the expressions of sexually selected traits has received less attention, although such variation underpins differences in male competitive abilities and female preference, which are central to sexual selection. In contrast to previous studies focusing on single traits, we used repeated measures of seven sexually selected morphological and behavioral traits in male black grouse (Tetrao tetrix) to quantify the effects of age and life span on their expressions and quantif…