Search results for " AROMA"
showing 10 items of 370 documents
Mono- and diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7
1999
Polycyclic aromatic hydrocarbon (PAH)-type compounds induce at least two rat UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT1A7. Among the glucuronidation reactions of PAH metabolites studied, mono- and diglucuronide formation of benzo[a]pyrene and chrysene-3,6-diphenol showed the highest induction factors in rat liver microsomes. Availability of AHH-1 cells stably expressing UGT1A7 allowed us to study whether this PAH-inducible isoform could catalyze benzo[a]pyrene and chrysene-3,6-diphenol glucuronidation. It was found that UGT1A7 indeed catalyzed mono- and diglucuronide formation of both benzo[a]pyrene and chrysene 3,6-diphenols. V79 cell-expressed rat UGT1A6 also catalyzed these re…
Single-digit nanomolar inhibitors lock the aromatase active site via a dualsteric targeting strategy
2022
The most frequently diagnosed breast cancer (BC) type in women expresses estrogen receptor (ER) , depends on estrogens for its growth, being classified as ER positive (ER+). The gold standard therapy for the treatment of this tumor relies on the inhibition of the aromatase enzyme, which catalyzes estrogen biosynthesis. Despite the clinical success of current aromatase inhibitors (AIs), after prolonged therapeutic regimens, BC ER + patients experience acquired resistance and disease relapse. This points up the urgent need for a newer generation of AIs able to overcome resistance issues, while mitigating toxicity and side effects of current therapies. Here we performed the synthesis, biologic…
A Bioinspired Approach to Tri-nor-guaianes. Synthesis of (−)-Clavukerin A
2006
A bioinspired approach to tri-nor-guaianes by degradation of the C-7 side chain of related guaia-11-enes is described. In this approach (-)-clavukerin A (1) is obtained by selective ozonolysis-Criegge rearrangement of (+)-1alphaH,7alphaH,10alphaH-guaia-4,11-dien-3-one (4) to afford 7beta-hydroxy and 7beta-acetoxy tri-nor-guaiane derivatives 6 and 7, respectively, which after elimination and deoxygenation give the title compound. The starting guaiadienone is readily obtained from commercially available santonin or (+)-dihydrocarvone.
Radical Cyclization and 1,5-Hydrogen Transfer in Selected Aromatic Diazonium Salts
2014
2-(Methyl(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbamoyl)thiophene-3-diazonium hydrogen sulfate 20, 2-(methyl(3-methyl-isoxazol-5yl)carbamoyl)-benzenediazonium hydrogen sulfate 21 and 2-(methyl(phenyl)carbamoyl)-benzenediazonium hydrogen sulphate 22 were synthesized and reacted with a CuSO4/NaCl/ascorbic acid combination to give complex mixtures. The structures of the reaction products were elucidated, depending upon the pathways followed. Compound 20 almost exclusively afforded an Ar-5 cyclization product and trace amounts of the product derived from a competing Ar-6 Pschorr closure. In the case of compound 21, the Ar-6 cyclization was not observed, while the Ar-5 cyclization and 1,5-hydrogen…
A quantitative method of photoadsorption determination for irradiated catalyst in liquid–solid system
2009
WOS: 000266963000002
Photocatalytic Oxidation of Aromatic Alcohols to Aldehydes in Aqueous Suspension of Home Prepared Titanium Dioxide. 1 Selectivity Enhancement by alip…
2008
Oxygenated aqueous suspensions of home-prepared (HP) and commercial TiO2 catalysts were used in a batch photoreactor for carrying out the oxidation of benzyl alcohol (BA) and 4-methoxybenzyl alcohol (MBA) under different operative conditions. HP catalysts were synthesized from TiCl4 and underwent a hydrolysis treatment of different times under mild conditions. The textural characterization of catalysts was carried out with XRD, SEM observations, BET surface area and porosity measurements. For both alcohols the main oxidation products were the corresponding aromatic aldehydes and CO2. The HP catalysts exhibited selectivity values towards the aldehyde production up to 28% (BA conversion: 50%)…
A reactor for photoelectrocatalytic oxidation of aromatic alcohols
2008
Phthalate esters (PEAs) and Polycyclic Aromatic Hydrocarbons (PAHs) in indoor dust matter of Palermo (Italy) area. Extraction, GC-MS analysis
2012
Studies on indoor pollution are important since people spend more than 80% of their time indoor environments. A variety of air pollutants, associated with volatile semi-volatile and particulate matter, are generated in indoor environment from human activities. Among the hazardous pollutants polycyclic aromatic hydrocarbons (PAHs) are important owing to their carcinogenicity and mutagenicity. Phthalates are introduced into the environment by anthropogenic sources. Phthalates with higher molecular weights are largely used as additives and plasticizers in plastic material (PVC), while those with lower molecular weights are components of solvents, adhesive, wax, ink, pharmaceutical products, et…
Piante medicinali in Sicilia: un’opportunità di sviluppo tra tradizione e innovazione
2012
L’area del Mediterraneo, caratterizzata da una estrema variabilità di ambienti naturali e quindi da un elevato grado di biodiversità vegetale, possiede un grande numero di specie dotate di proprietà medicinali; in Sicilia, molte di queste fanno parte da tempi remotissimi della tradizione popolare, che tuttora ne fa largo uso per l’automedicazione erboristica e in terapia veterinaria. In epoca recente, la crescente tendenza dell’industria e dei consumatori verso l’utilizzazione di prodotti “naturali” ha aperto la strada verso l’uso di piante medicinali anche in settori di mercato che, fino a qualche tempo fa, erano dominati dai prodotti di sintesi. In tale contesto, ci si interroga su come f…
Prove di pacciamatura con materiali organici su Origano (Origanum heracleoticum L.)
2005
La coltivazione delle piante aromatiche e medicinali, particolarmente quando condotta con i metodi dell’agricoltura biologica, si configura oggi come una possibilità di estremo interesse per il rilancio produttivo di numerose aree interne a rischio di marginalizzazione. Tuttavia, ancora numerosi sono gli aspetti da mettere a punto riguardo all’inserimento delle p.o. negli ordinamenti colturali italiani e siciliani in particolare, ed essi riguardano soprattutto interventi tecnici volti all’abbassamento del rapporto costo/ricavo. la messa a punto per queste dell’agrotecnica più opportuna, in grado contemporaneamente di: a. consentire l’ottenimento di rese ottimali, sia sul piano della quantit…