Search results for " ASSOCIATION"

How to make head or tail of ‘bridging’ and ‘bonding’?: addressing the methodological ambiguity1

2008

A distinction has recently been proposed between bridging (or encompassing) and bonding (or inward-looking) social networks. However, existing theoretical contributions remain vague as to the fundamental meaning of both concepts. As a consequence, two distinct interpretations have developed alongside each other. In the present paper, we employ data on voluntary association membership in Flanders to empirically illustrate that both approaches can lead to substantially different outcomes and therefore appear to tap into different dimensions of bridging versus bonding. These findings underline the problematic nature of the current conceptual ambiguity. We conclude that should the bridging/bond…

Polymorphisms in DCDC2 and S100B associate with developmental dyslexia

2015

Genetic studies of complex traits have become increasingly successful as progress is made in next-generation sequencing. We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. We used next-generation sequencing to identify single-nucleotide polymorphisms in the exons of these 11 genes in pools of 100 DNA samples of Finnish individuals with developmental dyslexia. Subsequent individual genotyping of those 100 individuals, and additional cases and controls from the Finnish and German populations, validated 92 out of 111 …

Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis

2010

Background: TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to extensively investigate TGR5 sequence variation in PSC, as well as functionally characterize detected variants.Methodology/Principal Findings: Complete resequencing of TGR5 was performed in 267 PSC patients and 274 healthy controls. Six nonsynonymous mutations were identified in addition to 16 other novel single-nucleotide polymorphisms. To investigate the impact from the nonsynonymous variants on TGR5, we created a receptor mod…

Proscribing the Nordic Resistance Movement in Finland: Analyzing the Process and its Outcome

2021

The Nordic Resistance Movement (NRM) was banned in Finland in 2020 after a court process lasting more than two and half years. This article details how effective the ban has been and how the organization has adapted to the ban, both during the process and after the verdict. The NRM has followed strategies similar to previous proscription cases, especially National Action in the UK in 2016, with whom NRM members discussed and shared experiences before the banning process began. Adaptation has meant new organizational forms and the founding of new associations. Before the ban, some commentators argued that it would only radicalize NRM members and that they might move to clandestine actions. B…

Sex-Specific Differences in the Control of Serum Concentrations of Glycine in Subjects with Metabolic Syndrome and Mendelian Randomization Analysis f…

2020

OBJECTIVES: Glycine is a novel circulating marker for metabolic diseases associated with lower type-2 diabetes and protection against obesity in some studies. Circulating glycine levels are genetically determined under the control of several loci. The locus most strongly associated is the carbamoyl-phosphate synthase I (CPS1). Interestingly, some sex-specific genome-wide association studies (GWAS) showed differences in the effect of the main single nucleotide polymorphisms (SNPs) in this locus on glycine levels (significant sex * CPS1 interactions). However, the potential mechanisms explaining this sex-heterogeneity are unknown. Therefore, our aims were: 1) to analyze whether the sex * CPS1…

Investigating consumers' representations of beers through a free association task: A comparison between packaging and blind conditions

2013

International audience; Food behavior has been shown to be influenced by top-down processes such as expectations generated from the mental representations of product. Investigating how a product is represented in consumers' mind is therefore essential to a better understanding of food behavior. As traditional and typical products are particularly prone to expectation effects, these products are well suited to explore consumer's mental representations. Among traditional products, beers are certainly of interest for both product development and marketing. A free association task was conducted in two evaluation conditions. Participants were asked to state what came to their mind while evaluati…

Food labels: Do consumers perceive what semiotics want to convey?

2011

In this research work, a multidisciplinary approach was applied to answer the question: do consumers perceive what semiotics want to convey? The idea behind was to determine if consumers' expectations and associations raised by simulated yogurt labels, designed with different sign combinations frequently applied in commercial products, were in agreement with results from a semiotic analysis, and to check for cultural differences, comparing results from two Spanish-speaking countries (Spain and Uruguay).A survey of the plain yogurt market was performed, followed by a semiotic analysis of the gathered labels performed by a team of semiotics experts. Only the non-verbal elements such as images…

UPC++ for bioinformatics: A case study using genome-wide association studies

2014

Modern genotyping technologies are able to obtain up to a few million genetic markers (such as SNPs) of an individual within a few minutes of time. Detecting epistasis, such as SNP-SNP interactions, in Genome-Wide Association Studies is an important but time-consuming operation since statistical computations have to be performed for each pair of measured markers. Therefore, a variety of HPC architectures have been used to accelerate these studies. In this work we present a parallel approach for multi-core clusters, which is implemented with UPC++ and takes advantage of the features available in the Partitioned Global Address Space and Object Oriented Programming models. Our solution is base…

Mujeres, trabajo y asociación rural

2019

Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation

2013

AbstractOmmatidial rotation is one of the most important events for correct patterning of the Drosophila eye. Although several signaling pathways are involved in this process, few genes have been shown to specifically affect it. One of them is nemo (nmo), which encodes a MAP-like protein kinase that regulates the rate of rotation throughout the entire process, and serves as a link between core planar cell polarity (PCP) factors and the E-cadherin–β-catenin complex. To determine more precisely the role of nmo in ommatidial rotation, live-imaging analyses in nmo mutant and wild-type early pupal eye discs were performed. We demonstrate that ommatidial rotation is not a continuous process, and …