Search results for " ASSOCIATION"
showing 10 items of 996 documents
WITHDRAWN: Association analysis between the early change of serum brain-derived neurotrophic factor (sBDNF) and final change of depression severity d…
2010
This article has been withdrawn at the request of the Editor-in-Chief. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster
2011
Alcohol dependence (AD) is an important contributory factor to the global burden of disease. The etiology of AD involves both environmental and genetic factors, and the disorder has a heritability of around 50%. The aim of the present study was to identify susceptibility genes for AD by performing a genome-wide association study (GWAS). The sample comprised 1333 male in-patients with severe AD according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and 2168 controls. These included 487 patients and 1358 controls from a previous GWAS study by our group. All individuals were of German descent. Single-marker tests and a polygenic score-based analysis to assess the …
A MULTI-LEVEL FUNCTIONAL STUDY OF A SNAP25 AT-RISK VARIANT FOR BIPOLAR DISORDER AND SCHIZOPHRENIA
2019
Background The synaptosomal associated protein SNAP25 is crucial for synaptic vesicle docking and fusion and has been associated with multiple psychiatric conditions. We recently identified a promoter variant in SNAP25, rs6039769, associated with bipolar disorder and gene expression in prefrontal cortex. Methods Here, we performed a genetic association study using this variation on two independent cohorts of 288 and 173 subjects with schizophrenia and 315 unaffected control individuals. We replicated our results using data from the schizophrenia group of the Psychiatric Genomics Consortium (PGC). Functional consequences combined both in vitro and post-mortem gene expression analysis on 30 p…
Quantifying the contamination by old main-sequence stars in young moving groups: the case of the Local Association
2009
The associations and moving groups of young stars are excellent laboratories for investigating stellar formation in the solar neighborhood. Previous results have confirmed that a non-negligible fraction of old main-sequence stars is present in the lists of possible members of young stellar kinematic groups. A detailed study of the properties of these samples is needed to separate the young stars from old main-sequence stars with similar space motion, and identify the origin of these structures. We used stars possible members of the young (~ 10 - 650 Myr) moving groups from the literature. To determine the age of the stars, we used several suitable age indicators for young main sequence star…
ROSAT PSPC/HRI observations of the open cluster NGC 2422
2002
We present the results of a ROSAT study of NGC 2422, a southern open cluster at a distance of about 470 pc, with an age close to the Pleiades. Source detection was performed on two observations, a 10-ks PSPC and a 40-ks HRI pointing, with a detection algorithm based on wavelet transforms, particularly suited to detecting faint sources in crowded fields. We have detected 78 sources, 13 of which were detected only with the HRI, and 37 detected only with the PSPC. For each source, we have computed the 0.2-2.0 keV X-ray flux. Using optical data from the literature and our own low-dispersion spectroscopic observations, we find candidate optical counterparts for 62 X-ray sources, with more than 8…
The Gaia-ESO Survey: Catalogue of Hα emission stars
2015
We discuss the properties of Hα emission stars across the sample of 22035 spectra from the Gaia-ESO Survey internal data release, observed with the GIRAFFE instrument and largely belonging to stars in young open clusters. Automated fits using two independent Gaussian profiles and a third component that accounts for the nebular emission allow us to discern distinct morphological types of Hα line profiles with the introduction of a simplified classification scheme. All in all, we find 3765 stars with intrinsic emission and sort their spectra into eight distinct morphological categories: single-component emission, emission blend, sharp emission peaks, double emission, P-Cygni, inverted P-Cygni…
X-ray spectral and timing characteristics of the stars in the young open cluster IC 2391
2005
We present X-ray spectral and timing analysis of members of the young open cluster IC 2391 observed with the XMM-Newton observatory. We detected 99 X-ray sources by analysing the summed data obtained from MOS1, MOS2 and pn detectors of the EPIC camera; 24 of them are members, or probable members, of the cluster. Stars of all spectral types have been detected, from the early-types to the late-M dwarfs. Despite the capability of the instrument to recognize up to 3 thermal components, the X-ray spectra of the G, K and M members of the cluster are well described with two thermal components (at kT$_1 \sim$ 0.3-0.5 keV and kT$_2 \sim$ 1.0-1.2 keV respectively) while the X-ray spectra of F members…
Optical spectroscopy of X-ray sources in the Taurus molecular cloud: discovery of ten new pre-main sequence stars
2008
We have analyzed optical spectra of 25 X-ray sources identified as potential new members of the Taurus molecular cloud (TMC), in order to confirm their membership in this SFR. Fifty-seven candidates were previously selected among the X-ray sources in the XEST survey, having a 2MASS counterpart compatible with a PMS star based on color-magnitude and color-color diagrams. We obtained high-resolution optical spectra for 7 of these candidates with the SARG spectrograph at the TNG telescope, which were used to search for Li absorption and to measure the Ha line and the radial and rotational velocities; 18 low-resolution optical spectra obtained with DOLORES for other candidate members were used …
Dynamic of the genetic structure of bacterial and fungal communities at different developmental stages of Medicago truncatula Gaertn. cv. Jemalong li…
2006
International audience; The genetic structure of bacterial and fungal communities was characterized in the rhizosphere of Medicago truncatula Gaertn. cv. Jemalong line J5 at five developmental stages (three vegetative and two reproductive stages), and in three compartments (bulk soil, rhizosphere soil and root tissues). The genetic structure of microbial communities was determined by cultivation-independent methods using directly extracted DNA that was characterized by automated ribosomal intergenic spacer analysis (ARISA). Principal component analyses (PCA) indicate that, for all developmental stages, the genetic structure of microbial communities differed significantly by compartment, wit…
Nymphaeetum candidae Miljan 1933 in Poland
2011
This paper presents the distribution, floristic composition and ecological requirements of the water plant community <em>Nymphaeetum candidae</em> Miljan 1933, belonging to the <em>Potametea</em> class. Until present this community has been reported only from north-eastern Poland. During present studies it was stated also in the south-western part of the country. <em>Nymphaeetum candidae</em> is considered to be a rare and endangered plant community in several countries of Central Europe.