Search results for " Active"

Black hole lightning due to particle acceleration at subhorizon scales

2015

Supermassive black holes with masses of millions to billions of solar masses are commonly found in the centers of galaxies. Astronomers seek to image jet formation using radio interferometry, but still suffer from insufficient angular resolution. An alternative method to resolve small structures is to measure the time variability of their emission. Here, we report on gamma-ray observations of the radio galaxy IC 310 obtained with the MAGIC telescopes revealing variability with doubling time scales faster than 4.8 min. Causality constrains the size of the emission region to be smaller than 20\% of the gravitational radius of its central black hole. We suggest that the emission is associated …

Monitoring the Morphology of M87* in 2009-2017 with the Event Horizon Telescope

2020

All authors: Wielgus, Maciek; Akiyama, Kazunori; Blackburn, Lindy; Chan, Chi-kwan; Dexter, Jason; Doeleman, Sheperd S.; Fish, Vincent L.; Issaoun, Sara; Johnson, Michael D.; Krichbaum, Thomas P.; Lu, Ru-Sen; Pesce, Dominic W.; Wong, George N.; Bower, Geoffrey C.; Broderick, Avery E.; Chael, Andrew; Chatterjee, Koushik; Gammie, Charles F.; Georgiev, Boris; Hada, Kazuhiro Loinard, Laurent; Markoff, Sera; Marrone, Daniel P.; Plambeck, Richard; Weintroub, Jonathan; Dexter, Matthew; MacMahon, David H. E.; Wright, Melvyn; Alberdi, Antxon; Alef, Walter; Asada, Keiichi; Azulay, Rebecca; Baczko, Anne-Kathrin; Ball, David; Baloković, Mislav; Barausse, Enrico; Barrett, John; Bintley, Dan; Boland, Wilf…

Multiband RadioAstron space VLBI imaging of the jet in quasar S5 0836+710

2019

Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.-- Open Access funding provided by Max Planck Society.

Relativistic beaming and gamma-ray brightness of blazars

2009

We investigate the dependence of gamma-ray brightness of blazars on intrinsic properties of their parsec-scale radio jets and the implication for relativistic beaming. By combining apparent jet speeds derived from high-resolution VLBA images from the MOJAVE program with millimetre-wavelength flux density monitoring data from Metsahovi Radio Observatory, we estimate the jet Doppler factors, Lorentz factors, and viewing angles for a sample of 62 blazars. We study the trends in these quantities between the sources which were detected in gamma-rays by the Fermi Large Area Telescope (LAT) during its first three months of science operations and those which were not detected. The LAT-detected blaz…

Budesonide in previously untreated autoimmune hepatitis

2005

Background: Autoimmune hepatitis (AIH) is a chronic liver disease that is effectively treated with immunosuppressive therapy. Predniso(lo)ne, often in combination with azathioprine, is the basic therapeutic option to induce remission. However, this regimen can cause numerous side effects. The aim of the present study was to evaluate budesonide as a treatment option in the induction of remission in patients with previously untreated AIH. Methods: Between October 1998 and August 1999, 12 patients were treated with 3 mg budesonide thrice daily for 3 months in this open one-arm multicenter phase IIa study. Primary end point was induction of remission indicated by a drop of aspartate aminotransf…

Synthetic Glycopeptides from the Mucin Family as Potential Tools in Cancer Immunotherapy

2006

Compared to glycoproteins of healthy cells, glycoproteins of tumor cells are often aberrantly glycosylated. Thus, glycopeptide fragments of surface glycoproteins of tumor cells are of interest as tumor-associated antigens for the distinction between normal and tumor cells. Cancer immunotherapy directed at selectively targeting these tumor-associated glycoprotein structure alterations--deficient glycosylation and, thus, exposure of peptide epitopes which are masked in normal cells--is considered a promising approach for the treatment of cancer. For this purpose, glycoproteins from the mucin family are of particular interest. Mucins belong to a class of heavily O-glycosylated, high-molecular …

Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development

2008

Abstract Purpose: Antibody-based cancer therapies have emerged as the most promising therapeutics in oncology. The purpose of this study was to discover novel targets for therapeutic antibodies in solid cancer. Experimental Design: We combined data mining and wet-bench experiments to identify strictly gastrocyte lineage–specific cell surface molecules and to validate them as therapeutic antibody targets. Results: We identified isoform 2 of the tight junction molecule claudin-18 (CLDN18.2) as a highly selective cell lineage marker. Its expression in normal tissues is strictly confined to differentiated epithelial cells of the gastric mucosa, but it is absent from the gastric stem cell zone. …

2021

Abstract Remote sensing-based measurements of solar-induced chlorophyll fluorescence (SIF) are useful for assessing plant functioning at different spatial and temporal scales. SIF is the most direct measure of photosynthesis and is therefore considered important to advance capacity for the monitoring of gross primary production (GPP) while it has also been suggested that its yield facilitates the early detection of vegetation stress. However, due to the influence of different confounding effects, the apparent SIF signal measured at canopy level differs from the fluorescence emitted at leaf level, which makes its physiological interpretation challenging. One of these effects is the scatterin…

Remote sensing of sunlight-induced chlorophyll fluorescence and reflectance of Scots pine in the boreal forest during spring recovery

2005

A measurement campaign to assess the feasibility of remote sensing of sunlight-induced chlorophyll fluorescence (ChlF) from a coniferous canopy was conducted in a boreal forest study site (Finland). A Passive Multi-wavelength Fluorescence Detector (PMFD) sensor, developed in the LURE laboratory, was used to obtain simultaneous measurements of ChlF in the oxygen absorption bands, at 687 and 760 nm, and a reflectance index, the PRI (Physiological Reflectance Index), for a month during spring recovery. When these data were compared with active fluorescence measurements performed on needles they revealed the same trend. During sunny days fluorescence and reflectance signals were found to be str…

Grapevine physiological response to row orientation-induced spatial radiation and microclimate changes

2020

Terroir factors and vineyard practices largely determine canopy and root system functioning. In this study, changes in soil conditions, multi-level (vertical, horizontal) light interception (quantitative, photographic, schematic, 3D modelled), leaf water potential and photosynthetic activity were measured during the grape ripening period on NS, EW, NE-SW, and NW-SE orientated (Southern Hemisphere) vertically trellised Shiraz grapevine canopies. It was hypothesised that the spatial radiation interception angle and radiation distribution of differently orientated and vertically trained grapevine rows would affect soil conditions and vine physiological activity. Soil water content showed an in…