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showing 10 items of 533 documents
Mitochondrial Toxicity in HAART: An Overview of In Vitro Evidence
2011
The combined antiretroviral therapeutic approach currently employed for the treatment of HIV infection, known as Higly Active Antiretroviral Therapy (HAART), has dramatically reduced AIDS-related morbidity and mortality. However, the adverse reactions associated with the long term use of this therapy have now become a major issue and researchers have focused on understanding the cellular mechanisms underlying these drug-induced detrimental effects which englobe a large list of different events including rash and hypersensibility reactions, hepatotoxicity, metabolic disturbances including lipodystrophy, and other metabolic syndrome-like disturbances such as hyperlactatemia, hyperlipedimia, i…
Adverse Reactions to Anti-SARS-CoV-2 Vaccine: A Prospective Cohort Study Based on an Active Surveillance System
2022
To date, Coronavirus disease (COVID-19) has caused high morbidity and mortality worldwide. To counteract the pandemic scenario, several vaccines against the etiological factor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed and tested. At the end of December 2020, BNT162b2 (Comirnaty, Pfizer-BioNTech) was the first and only authorized vaccine in Italy for selected categories, such as healthcare workers, fragile patients and people aged over 80 years old. To master our knowledge about BNT162b2 adverse reactions (ARs), an active surveillance system based on instant messaging was realized for voluntary participants who had been vaccinated at COVID-19 Vaccination …
Photosynthesis of the red alga Gracilaria chilensis under natural solar radiation in an estuary in southern Chile
2005
The photosynthetic performance and pigment content of Gracilaria chilensis Bird, McLachlan, and Oliveira were measured under natural solar radiation in the Quempillen river estuary (southern Chile) in order to assess the short-term acclimation of this species to the current levels of ultraviolet (UV) radiation during midsummer. The effect of the tidal fluctuation was evaluated in algae exposed for 3 days to two light climates in cages suspended at two depths (0.5 and 1.5 m from the bottom). Responses to high solar radiation at noon were also assessed to gain insights into rapid photochemical kinetics and the degree of photoinhibition. Results indicated that G. chilensis is a shade-adapted s…
On the Coronal Temperature in Solar Microflares
2020
We present a study of solar imaging and spectral observations of a microflare, focusing on the temperature diagnostics provided by the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory, and the Extreme-Ultraviolet Imaging Spectrometer (EIS) on board Hinode. Our data analysis, in particular from the emission in the 131 and 94 Å channels, indicates that the heated plasma reaches temperatures of ≿10 MK, at odds with a previous analysis of the same event, and we discuss the reason for the discrepancy. A particularly interesting aspect is the likely presence of the Fe XXIII 263.76 Å line, though weak, in EIS spectra in the early phases of the event, supporting the presen…
Accurate ab initio density fitting for multiconfigurational self-consistent field methods
2008
Using Cholesky decomposition and density fitting to approximate the electron repulsion integrals, an implementation of the complete active space self-consistent field (CASSCF) method suitable for large-scale applications is presented. Sample calculations on benzene, diaquo-tetra- μ -acetato-dicopper(II), and diuraniumendofullerene demonstrate that the Cholesky and density fitting approximations allow larger basis sets and larger systems to be treated at the CASSCF level of theory with controllable accuracy. While strict error control is an inherent property of the Cholesky approximation, errors arising from the density fitting approach are managed by using a recently proposed class of auxi…
The DEPFET based Focal Plane Detectors for MIXS on BepiColombo
2010
X-ray detectors based on arrays of DEPFET macropixels, which consist of a silicon drift detector combined with a detector/amplifier structure DEPFET as readout node, provide a convenient and flexible way to adapt the pixel size of a focal plane detector to the resolving power of any given X-ray optical system. Macropixels combine the traditional benefits of an SDD, like scalability, arbitrary geometry and excellent QE even in the low energy range, with the advantages of DEPFET structures: Charge storage capability, near Fano-limited energy resolution, low power consumption and high speed readout. Being part of the scientific payload of ESA's BepiColombo mission, the MIXS instrument will be …
Size-consistent self-consistent configuration interaction from a complete active space : Excited states
1998
The self-consistent size consistent on a complete active space singly and doubly configuration interaction (SC)2CAS-SDCI method is applied to excited states. The (SC)2 correction is performed on a closed shell state, and the excited states are obtained by diagonalization of the dressed matrix. A theoretical justification of the transferability of the improvement concerning the dressing state to all roots of the matrix is presented. The method is tested by three tests on the spectrum of small molecules. sanchezm@uv.es ; nebot@uv.es
Surface Hopping Dynamics Including Intersystem Crossing using the Algebraic Diagrammatic Construction Method
2017
We report an implementation for employing the algebraic diagrammatic construction to second order [ADC(2)] ab initio electronic structure level of theory in nonadiabatic dynamics simulations in the framework of the SHARC (surface hopping including arbitrary couplings) dynamics method. The implementation is intended to enable computationally efficient, reliable, and easy-to-use nonadiabatic dynamics simulations of intersystem crossing in organic molecules. The methodology is evaluated for the 2-thiouracil molecule. It is shown that ADC(2) yields reliable excited-state energies, wave functions, and spin-orbit coupling terms for this molecule. Dynamics simulations are compared to previously re…
LeMMINGs - IV. The X-ray properties of a statistically complete sample of the nuclei in active and inactive galaxies from the Palomar sample
2022
All 280 of the statistically complete Palomar sample of nearby ( 20° have been observed at 1.5 GHz as part of the LeMMINGs e-MERLIN legacy survey. Here, we present Chandra X-ray observations of the nuclei of 213 of these galaxies, including a statistically complete sub-set of 113 galaxies in the declination range 40° <δ < 65°. We observed galaxies of all optical spectral types, including ‘active’ galaxies [e.g. low-ionization nuclear emission line regions (LINERs) and Seyferts] and ‘inactive’ galaxies like HII galaxies and absorption line galaxies (ALG). The X-ray flux limit of our survey is 1.65 × 10−14 erg s−1 cm−2 (0.3−10 keV). We detect X-ray emission coincident within 2 arcsec of the n…
INFLUENCE OF UNCERTAINTIES ON PD TUNING
2013
The aim of this work is to present a method for tuning the parameters of PD controller under the influences of the uncertainties, in order to stabilize the position of a rotor supported by active magnetic bearings (AMBs). The uncertainties are relative to mass, transverse and polar moment of inertia of the rotor. The introduction of the uncertainties is due to an incomplete modeled dynamic of the system or in the case the system being subjected to a parametric variation. The presence of the uncertainties produces a set of differences among the values of the output. Poles displacement method is used to reach the asymptotically stability condition characterized by a periodic oscillation durin…