Search results for " Active"

Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice.

2010

The constitutive androstane receptor (CAR) is a nuclear receptor expressed in the liver and involved in xenobiotic metabolism. The aim of this study was to assess whether pharmacological CAR activation could affect neutral sterol and bile acid elimination under conditions of cholesterol overload.Wild type, Car-/-, ApoE-/-, and low-density lipoprotein receptor (Ldlr)-/- mice fed a western-type diet were treated with the CAR agonist TCPOBOP.CAR activation was associated with a decrease in faecal cholesterol output related to the repression of the Abcg5/g8 cholesterol transporters. In contrast, TCPOBOP treatment induced a marked increase (up to three fold, p0.01) in the elimination of faecal b…

More about genetically modified tumour vaccines

1998

A Comparative Study of Mechanical and Microstructural Behavior for Metal Active Gas and Friction Stir Welded Micro-Alloyed Structural Steel

2022

Manufacturing tiny components into gigantic structures seems unimaginable without welding connections, whether it is for materials, parts, structures, or equipment. In the recent competitive market scenario, manufacturing industries are desperately looking for a viable alternative to fusion-based conventional material joining technologies, to improve upon cost-effectiveness along with performance. The present investigation is to evaluate the performance of structural steel thick plate joints prepared by advanced solid-state friction stir welding (FSW) over conventional metal active gas welding (MAG). The FSW experiments were carried out with different tool designs and configurations. The ou…

Incremental elastoplastic analysis for active macro-zones

2012

In this paper a strategy to perform incremental elastoplastic analysis using the symmetric Galerkin boundary element method for multidomain type problems is shown. The discretization of the body is performed through substructures, distinguishing the bem-elements characterizing the so-called active macro-zones, where the plastic consistency condition may be violated, and the macro-elements having elastic behaviour only. Incremental analysis uses the well-known concept of self-equilibrium stress field here shown in a discrete form through the introduction of the influence matrix (self-stress matrix). The nonlinear analysis does not use updating of the elastic response inside each plastic loop…

Giant cell arteritis associated with chronic active Epstein-Barr virus infection

2013

Giant cell arteritis is an inflammatory vasculopathy that preferentially affects medium-sized and large arteries. A viral cause has been suspected but not confirmed in polymyalgia rheumatica and giant-cell arteritis. We report the case of a 81-year-old female who suffered from chronic active Epstein-Barr virus infection and developed giant cell temporal arteritis.

Effect of Sitting Posture on Sit-Skiing Economy in Non-disabled Athletes

2020

This study focused on resolving the differences in economy between two common sit-skiing postures used by disabled athletes, suspected to be the most and least effective. Ten experienced non-disabled male cross-country skiers went through an incremental testing protocol with an ergometer simulating double poling in two sitting postures “kneeing” and “knee-high.” The protocol consisted of 3 × 4 min steady-state stages (13, 22, and 34% of maximal sprint power output). Subjects' respiratory gases and heart rate were measured and blood lactate concentrations were determined. In addition, pulling forces and motion capture recordings were collected. Oxygen consumption was 15.5% (p < 0.01) higher …

Latest Developments and Results of Radiation Tolerance CMOS Sensors with Small Collection Electrodes

2020

The development of radiation hard Depleted Monolithic Active Pixel Sensors (DMAPS) targets the replacement of hybrid pixel detectors to meet radiation hardness requirements of at least 1.5e16 1 MeV neq/cm2 for the HL-LHC and beyond. DMAPS were designed and tested in the TJ180 nm TowerJazz CMOS imaging technology with small electrodes pixel designs. This technology reduces costs and provides granularity of 36.4x36.4 um2 with low power operation (1 uW/pixel), low noise of ENC < 20 e-, a small collection electrode (3 um) and fast signal response within 25 ns bunch crossing. This contribution will present the latest developments after the MALTA and Mini-MALTA sensors. It will illustrate the imp…

Diurnal Cycle Relationships between Passive Fluorescence, PRI and NPQ of Vegetation in a Controlled Stress Experiment

2017

In order to estimate vegetation photosynthesis from remote sensing observations; some critical parameters need to be quantified. From all absorbed light; the plant needs to release any excess that is not used for photosynthesis; by non-photochemical quenching; by fluorescence emission and unregulated thermal dissipation. Non-photochemical quenching (NPQ) processes are controlled photoprotective mechanisms which; once activated; strongly control the dynamics of photochemical efficiency. With illumination conditions increasing and decreasing during a diurnal cycle; photoprotection mechanisms needs to change accordingly. The goal of this work is to quantify dynamic NPQ; measured from active fl…

Comparison of Classroom-based Sedentary Time and Physical Activity in Conventional Classrooms and Open Learning Spaces Among Elementary School Studen…

2021

European children and adolescents spend most of their daily life and especially their school hours being sedentary which may increase their risk for chronic non-communicable diseases later in life. After the curriculum reform of Finnish basic education in 2014, most of the new or renovated comprehensive schools in Finland incorporate open and flexible classroom designs. Their open learning spaces may provide students opportunities to reduce sedentary behavior during school hours. Thus, waist-worn accelerometers were used to assess classroom-based sedentary time (ST), the number of breaks from sedentary time (BST), and physical activity (PA) among cross-sectional samples of 3rd and 5th grade…

Verso una geografia per la partecipazione

2018

This article introduces the contributions collected in the special issue no. 1/2018 of “geotema” and presented at the 4th Study Day on Territorial Identities (Rome, September 22nd, 2017), promoted by the homonymous research group of the A.Ge.I. (Associations of Italian Geographers). The paper aims at discussing some basic questions on participatory processes, in order to pursue four objectives: 1) to recall some of the main issues that revolve around the topic of citizen participation in territorial decision-making processes; 2) to specify the ties between territorial identity (as intended by the research group) and participatory processes; 3) to highlight the questions raised by the contri…