Search results for " Administration"
showing 10 items of 4299 documents
Les instruments fiscaux de la RSE
2013
National audience
Biodistribution of Insulin-Nanogels in Mouse: A Preliminary Study for the Treatment of Alzheimer's Disease
2017
A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IR signaling are involved in brain cognitive functions and their dysfunction is implicated in Alzheimer's disease (AD) neurodegeneration. Thus, administration of insulin could be a strategy for AD treatment. For this aim we have designed, synthesized and characterized a nanogel system (NG) that has been conjugated to insulin molecules (NG-In) to deliver the protein into the brain, as a tool for the development of a new therapy against AD. In our preclinical study in mice, intraperitoneal injection of fluorescent-labeled NG has allowed to determine the biodistribution of NG vs time in the whole body and its clearance th…
Valeur boursière versus valeur comptable
2011
International audience; Cet article a pour objet d’apporter une explication à l’écart constaté entre la valeur comptable et la valeur boursière des sociétés. Nous avons supposé qu’il peut être expliqué par l’irrationalité et « l’auto-référentialité » du marché, ainsi que par l’incapacité du modèle comptable traditionnel à traduire la valeur de la firme. Nos résultats corroborent la majorité de nos hypothèses et montrent que la distorsion entre la valeur comptable et la valeur boursière est une conséquence directe de la comptabilité au coût historique, de la prudence comptable, de la non-activation des certains éléments immatériels, ainsi que de la mauvaise évaluation (mispricing) des titres…
The need for information in purchase situation and the information behavior in front of the shelf : use and effects of electronic interactive communi…
1999
The classic approach of buying behavior supposes that the consumption value derives from the evaluation of the technical, functionnal and symbolic features of the product. But, most of recents works use an experiential approach, for which the anticiped situation of consumption or use and the self concept are the essential elements of the consumption value. This thesis, devoted to information behavior in buying situation, attemps to conciliate these two paradigms until here opposite. The first part of this search investigates the concept of need for information. Its results, according to us, the activation ot two schemes, the first concerning the product acquisition, the second relative to t…
INTERNAL AUDIT: DEFINING, OBJECTIVES, FUNCTIONS AND STAGES
2010
This article aims, through a detailed presentation as to provide clarification for a better understanding of what internal audit definition, objectives, functions and stages of its development mean. It is also exposed a brief history about the emergence and development of internal audit and regulatory framework. I also plan to linking theory and practice by reference to documents used: both the evidence considered and especially those prepared by the auditors in connection with the performance audit and its use in the audit report.
The value-added internal audit in public administration in Latvia
2019
The quality of internal audit and the added value of internal audit are unanswered questions in many public institutions in Latvia and around the world. This research was aimed at determining the evaluation approach of internal audit in the public sector of Latvia and developing a list of added value or benefits of the internal audit in a local government. The monographic method and the survey method, an expert survey, were used in the paper. The author has developed a valuation approach of internal audit in local governments. The author offers applying the approach developed when carrying out external evaluations to the commission of the responsible ministry in the sector, the representati…
Public Internal Control in the European Union
2015
Public internal control differs from country to country as it has to fit into the respective overall governance arrangements with the government and the supreme audit institution as well as the accountability arrangements that exist between stakeholders. The aim of this research is to find out common and different internal control elements in twelve European Union (EU-12) countries. The tasks of this research are: to analyse revenue indicators in the EU countries, to analyse internal control systems in the EU countries, to make conclusions and to make proposals for further research tasks about the internal control of the administration of Latvia and improvements of the internal audit system…
Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration
2019
Intravitreal administration of anti-vascular endothelial growth factor (VEGF) antibodies has become the standard treatment for Age-Related Macular Degeneration; however, the knowledge of their pharmacokinetics is limited. A comprehensive review of the preclinical and clinical pharmacokinetic data that were obtained in different studies with intravitreal bevacizumab, ranibizumab, and aflibercept has been conducted. Moreover, the factors that can influence the vitreous pharmacokinetics of these drugs, as well as the methods that were used in the studies for analytical determination, have been exposed. These anti-VEGF drugs present different charge and molecular weights, which play an importan…
Management du consommateur multicanal : Importance de l’intégration perçue de la gestion de la fidélité
2013
La gestion de la fidélité constitue l’une des préoccupations majeures des managers des enseignes multicanal. Comment retenir mes clients multicanal ? Et comment convertir mes shoppers multicanal en clients multicanal ? Telles sont les questions auxquelles ce papier vise à répondre, à travers une étude quantitative auprès de 343 consommateurs multicanal. Les résultats montrent un impact significatif de l’intégration perçue de la gestion de la fidélité sur la confiance dans l’enseigne multicanal et sur les comportements multicanal. Ils montrent également le rôle de l’intégration perçue de la gestion de la fidélité dans le management des consommateurs multicanal. Managing loyalty is one of the…
Contribution à l'étude du slack organisationnel : le cas des dépenses d'investissements dans une grande entreprise industrielle
2012
Contribution to the Study of the Organizational Slack : The Case of Investment Expenditure in a Big Industrial Company This paper contributes to research on organizational slack. The slacks integrated into capital expenditure have been little studied. The economic crisis in 2008-2009 represents a good opportunity to analyze these slacks. A longitudinal case study has been carried out in an industrial company from 2006 to 2010