Search results for " African"

showing 10 items of 198 documents

“Historical fiction is back”: (Non)Fictional Pasts and Presents in Fred Khumalo’s metahistorical romance, The Longest March

2023

International audience; This article examines the ways Fred Khumalo’s second historical novel, The Longest March, blends different genres – from the use of gothic tropes to the rewriting of historical romances – to reflect on both the fabricated and limited nature of narrative, as well as its necessity in the South African context. The article concludes that The Longest March qualifies as a “metahistorical romance”, as it blurs the boundary between fiction and nonfiction while questioning historical discourse.

South African history[SHS.LITT] Humanities and Social Sciences/Literature[SHS.LITT]Humanities and Social Sciences/LiteratureFred KhumaloGothic literatureSouth African literatureHistorical fiction
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Lattice-particle simulation of stress patterns in a Rwenzori-type rift transfer zone

2011

Abstract A new 3D spring lattice computer model has been developed and used to calculate the stress-field in the vicinity of a rift transfer zone. The numerical setup is based on the Rwenzori block, a transfer zone in the Western Branch of the East African Rift Valley. The study has two closely related, yet independent aims: primarily to gain insight into the pattern and the causes of the stress field in the Rwenzori area. The second aim is the evaluation of the model itself, based on a comparison of the model results with local geological structures. The simulations calculate the stress in the brittle part of the crust, at the topographic surface and at a depth of 10 km. The model does the…

Stress (mechanics)Stress fieldBrittlenessRiftLithosphereLattice (order)East African RiftGeologyCrustGeologySeismologyEarth-Surface ProcessesJournal of African Earth Sciences
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Strontium and argon isotopic homogenization of pelitic sediments during low-grade regional metamorphism: The pan-African upper Damara sequence of Nor…

1979

Abstract The fine mineral fractions extracted from pelitic sediments of the Eocambrian upper Damaran Mulden Group were subjected to a detailed isotopic study by the Rb-Sr and K-Ar methods in combination with a mineralogical analysis by X-ray diffractometry. The sediments contain two major parageneses of metamorphic origin which can be related to two separate low-grade regional metamorphic events of anchizonal intensity with temperatures between 250 and 300°C and pressures up to 2 kbar. These events are dated at about 535 m.y. and 455 m.y. respectively (with λ( 87 Rb) = 1.42 × 10 −11 yr −1 ). Anomalously high K-Ar ages on samples from specific stratigraphic horizons can be related to open sy…

StrontiumPan africanMetamorphic rockGeochemistrychemistry.chemical_elementStratigraphic unitMetamorphismGeophysicschemistrySpace and Planetary ScienceGeochemistry and PetrologyEarth and Planetary Sciences (miscellaneous)PeliteSedimentary rockStilpnomelaneGeologyEarth and Planetary Science Letters
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PAN-AFRICAN MOBILE BELTS AS EVIDENCE FOR A TRANSITIONAL TECTONIC REGIME FROM INTRAPLATE OROGENY TO PLATE MARGIN OROGENY

1979

Pan-African belts of the African mainland and the Arabian-Nubian Shield exhibit evolutionary features which are either compatible with intracontinental ensialic development or with plate margin and Wilson cycle tectonics. Some of these belts are discussed and, considered together, they appear to reflect variations in crustal mobility during a transitional tectonic regime from intraplate to plate margin orogeny which lasted some 50. Ma from ca. 1000 Ma to ca. 500 Ma ago.

TectonicsPaleontologyWilson cycleMargin (machine learning)Pan africanEarth scienceShieldIntraplate earthquakeOrogenyGeology
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Termini Imerese (PA) [Sito 88]

2016

This work will examine the imports of African pottery at Termae Himeraeae, pointing to the atelier of origin and identifying local imitations of African types, according to archaeometrical analyses.

Termini Imerese African pottery archaeometrical analysesSettore L-ANT/09 - Topografia AnticaTermini Imerese ceramica africana analisi archeometricheSettore L-ANT/07 - Archeologia Classica
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International solidarity in the GDR and transnationality: an analysis of primary school materials for Namibian child refugees

2014

As part of a solidarity project between the South West African People’s Organization (SWAPO) and the German Democratic Republic (GDR), approximately 430 Namibian children were brought to the GDR from 1979 to 1989 to be trained as an elite for a future liberated Namibia. The children attended school in the GDR until they were brought back to Namibia in August 1990. The school lessons intertwined topics about Namibia and SWAPO with the usual GDR school curriculum. The linchpin of this intertwining was the socialist ideal of international solidarity. This article uses an objective-hermeneutic analysis to show how the school materials produced transnationality.

Transnationalitymedia_common.quotation_subjectRefugeeGender studiesSolidaritylanguage.human_languageDemocracyGermanWest africanPolitical scienceElitelanguageCurriculummedia_commonTransnational Social Review
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African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune system

2019

Significance Many parasites escape the host immune system by undergoing antigenic variation, a process in which surface antigens are regularly shed and replaced by new ones. Trypanosoma brucei employs multiple sophisticated molecular mechanisms to ensure the expression of a homogeneous VSG coat. We generated a mutant parasite that expresses multiple distinct VSGs and studied the consequences of having a multi-VSG coat during an infection. We showed that expression of multiple VSGs makes the parasites more vulnerable to the immune response, which can now control the trypanosomes from the onset of the infection, allowing most mice to survive. In the future, trypanosome infections may be treat…

Trypanosoma brucei bruceiParasitemiaBiologyTrypanosoma bruceiParasitemiaMicrobiologyHost-Parasite InteractionsMice03 medical and health sciencesImmune systemRAG2HMGB Proteinsparasitic diseasesmedicineAnimalsTrypanosoma brucei030304 developmental biologychemistry.chemical_classification0303 health sciencesMultidisciplinarymonoallelic expressionTDP1030306 microbiologyBiological Sciencesbiology.organism_classificationAcquired immune systemmedicine.diseaseAntigenic VariationVirologyadaptive immune response3. Good healthChromatinTrypanosomiasis AfricanPNAS PluschemistryImmune SystemGlycoproteinTrypanosomiasisVariant Surface Glycoproteins Trypanosomavariant surface glycoproteinProceedings of the National Academy of Sciences
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Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis

2019

This paper describes an optimization strategy of the highly active vinyl ketone 3 which was recognized as a strong inhibitor of rhodesain of Trypanosoma brucei rhodesiense, endowed with a ksecond v...

Trypanosoma brucei rhodesienseStrong inhibitorKetoneStereochemistryProtein ConformationPeptide01 natural sciences03 medical and health sciencesStructure-Activity RelationshipSUBSTRATEDrug DiscoverymedicineHumansAfrican trypanosomiasisSulfonesBIOLOGICAL EVALUATION030304 developmental biologyWARHEADchemistry.chemical_classification0303 health sciencesMolecular StructureChemistryDERIVATIVESTrypanosoma brucei rhodesienseCYSTEINE PROTEASES RHODESAIN BIOLOGICAL EVALUATION CATHEPSIN-L INHIBITORS BRUCEI PEPTIDOMIMETICS FALCIPAIN-2 DERIVATIVES SUBSTRATE WARHEADBRUCEImedicine.diseaseFALCIPAIN-2Trypanocidal Agents0104 chemical sciences010404 medicinal & biomolecular chemistryCysteine EndopeptidasesTrypanosomiasis AfricanCYSTEINE PROTEASES RHODESAINCATHEPSIN-LMolecular MedicineINHIBITORSPEPTIDOMIMETICS
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Development of Novel Benzodiazepine-Based Peptidomimetics as Inhibitors of Rhodesain from Trypanosoma brucei rhodesiense.

2020

Starting from the reversible rhodesain inhibitors 1 a-c, which have Ki values towards the target protease in the low-micromolar range, we have designed a series of peptidomimetics, 2 a-g, that contain a benzodiazepine scaffold as a β-turn mimetic; they are characterized by a specific peptide sequence for the inhibition of rhodesain. Considering that irreversible inhibition is strongly desirable in the case of a parasitic target, a vinyl ester moiety acting as Michael-acceptor was introduced as the warhead; this portion was functionalized in order to evaluate the size of corresponding enzyme pocket that could accommodate this substituent. With this investigation, we identified an irreversibl…

Trypanosoma brucei rhodesiensehuman African trypanosomiasiStereochemistryPeptidomimeticmedicine.medical_treatmentSubstituentAntiprotozoal AgentsTrypanosoma bruceiCysteine Proteinase Inhibitors01 natural sciencesBiochemistrychemistry.chemical_compoundBenzodiazepinesStructure-Activity RelationshipDrug DevelopmentParasitic Sensitivity TestsDrug DiscoverymedicineMoietyTrypanosoma bruceiGeneral Pharmacology Toxicology and PharmaceuticsPeptide sequencePharmacologyrhodesainProteasebiologyDose-Response Relationship DrugMolecular Structure010405 organic chemistryOrganic ChemistryTrypanosoma brucei rhodesiensebenzodiazepine scaffoldbiology.organism_classificationpeptidomimetic0104 chemical sciences010404 medicinal & biomolecular chemistryCysteine EndopeptidaseschemistryMolecular MedicinePeptidomimeticsMichael acceptorLead compoundChemMedChem
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Distribution et abondance des mouches piqueuses (Glossinidae, Stomoxys et Tabanidae) dans deux parcs nationaux du Gabon.

2015

11 pages; International audience; In order to minimize risks of pathogen transmission with the development of ecotourism in Gabon, a seasonal inventory has been performed in five contrasted biotopes in Ivindo (INP) and Moukalaba-Doudou (MDNP) National Parks. A total of 10,033 hematophagous flies were captured. The Glossinidae, with six different species identified, was the most abundant group and constitutes about 60% of the captured flies compared to the Stomoxys (6 species also identified) and Tabanidae with 28% and 12%, respectively. The Glossinidae showed a higher rate of capture in primary forest and in research camps. In INP, the Stomoxys showed a higher rate of capture in secondary f…

Tsetse FliesParks RecreationalPopulation DynamicsClimatic seasons[SDV.BID]Life Sciences [q-bio]/BiodiversityForestsDistributionlcsh:Infectious and parasitic diseasesSpecies SpecificityAnimalslcsh:RC109-216GabonEcosystemNational Parks[ SDV.BID ] Life Sciences [q-bio]/Biodiversity[ SDE.BE ] Environmental Sciences/Biodiversity and EcologyHematophagous fliesDipteraMuscidaeHumidityGrasslandGlossinidaeInsect VectorsTrypanosomiasis AfricanVirus DiseasesSeasons[SDE.BE]Environmental Sciences/Biodiversity and EcologyAnimal DistributionResearch Article
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