Search results for " Ala"

showing 10 items of 239 documents

Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

2019

Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in differentiating subjects whose cancer may progress to a malignant situation. Regarding malignancy, the role of lymphocyte subsets and cytokines at the beginning of neoplastic diseases is now incontestable. In this review, we have concentrated our attention on the equilibrium between the diverse lymphocyte subsets and the cytokine system and summarized the current state of knowledge, providing an overview of the condition of the entire system in …

0301 basic medicineT lymphocytesimmunosurveillanceReviewMalignancyMonoclonal Gammopathy of Undetermined SignificanceCatalysisInorganic Chemistrylcsh:Chemistry03 medical and health sciences0302 clinical medicineImmune systemSettore MED/43 - Medicina LegaleMonitoring ImmunologicGammopathycytokineMedicineHumansPhysical and Theoretical ChemistryMolecular Biologylcsh:QH301-705.5SpectroscopyMultiple myelomamonoclonal gammopathy of undetermined significance; multiple myeloma; T lymphocytes; cytokine; alarmin; inflammation; immunosurveillancebusiness.industryOrganic ChemistryCancerGeneral Medicinealarminmedicine.diseaseLymphocyte SubsetsComputer Science ApplicationsImmunosurveillancemultiple myeloma030104 developmental biologylcsh:Biology (General)lcsh:QD1-999inflammation030220 oncology & carcinogenesisImmunologyMonoclonalCytokinesbusinessMonoclonal gammopathy of undetermined significance
researchProduct

Factors Associated With Weight Gain in People Treated With Dolutegravir.

2020

AbstractBackgroundAn unexpected excess in weight gain has recently been reported in the course of dolutegravir (DTG) treatment. The aim of the present study was to investigate whether weight gain differs among different DTG-containing regimens.MethodsAdult naïve and experienced people with HIV (PWH) initiating DTG-based antiretroviral therapy (ART) between July 2014 and December 2019 in the Surveillance Cohort Long-Term Toxicity Antiretrovirals (SCOLTA) prospective cohort were included. We used an adjusted general linear model to compare weight change among backbone groups and a Cox proportional hazard regression model to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for …

0301 basic medicinemedicine.medical_specialtyWeight gain.HIV metabolic complications030106 microbiologyHIV metabolic complicationTDFEmtricitabineTenofovir alafenamidedolutegravir HIV metabolic complications TAF TDF weight gain.03 medical and health scienceschemistry.chemical_compound0302 clinical medicineAbacavirInternal medicinemedicineMajor Article030212 general & internal medicinebusiness.industryWeight changeLamivudineweight gaindolutegravirInfectious DiseasesAcademicSubjects/MED00290OncologychemistryTAFRilpivirineDolutegravirmedicine.symptombusinessWeight gainmedicine.drugOpen forum infectious diseases
researchProduct

Presentación e ingreso de determinadas declaraciones y autoliquidaciones tributarias durante el Estado de Alarma

2020

[ES] Desde la declaración del estado de alarma como consecuencia de la crisis sanitaria provocada por el COVID-19, han sido aprobados numerosos reales decretos. Entre ellos, uno de los principales desde la perspectiva tributaria es el Real Decreto-ley 14/2020, en virtud del cual se ampliaba el plazo de presentación e ingreso de numerosos tributos, destacando, entre otros, el IVA y el IS. Además, las comunidades autónomas también han aprobado medidas relativas a la ampliación del plazo de presentación e ingreso de los tributos respecto de los que tienen atribuidas competencias.

:CIENCIAS JURÍDICAS [UNESCO]Deferment of paymentAutonomous regionAutoliquidaciones tributariasDeclaraciones tributariasEstado de alarmaTax returns extensionComunidades autónomasPayment in instalmentsUNESCO::CIENCIAS JURÍDICASState of alarmFraccionamientoECONOMIA FINANCIERA Y CONTABILIDADAplazamientoAmpliación plazo
researchProduct

Los plazos para interponer recursos y de determinados procedimientos y actos tributarios durante el Estado de Alarma.

2020

[EN] Royal Decree 463/2020, of March 14, declared the state of alarm as a consequence of COVID-19. From this declaration, a series of royal decree-laws have followed one another that have introduced a series of changes in the financial system to adapt the tax obligations to the health crisis situation. In this sense, the deadlines for filing resource, the forms and deadlines for filing and paying declarations and self-settlement have been modified, as well as certain procedures and acts while this exceptional regime lasts. In this study we are going to analyze the adoption of these measures and their accommodation in Tax Law.

:CIENCIAS JURÍDICAS [UNESCO]ProcedimientosAlarm statusTax returnsUNESCO::CIENCIAS JURÍDICASPlazos tributariosDeclaraciones tributariasEstado de alarmaTax deadlinesECONOMIA FINANCIERA Y CONTABILIDADProceduresResourcesRecursos
researchProduct

El Estado de Alarma y el uso del Real Decreto Ley para modificar normas tributarias

2020

[EN] The health crisis produced by COVID-19 led to the declaration of the state of alarm by means of Royal Decree 463/2020, of March 14. From that moment, and as a consequence of the measures adopted, among which were: the suspension of the opening to the public of the premises and retail establishments; limiting freedom of movement; and the suspension of administrative terms, the Government proceeded to issue a series of Royal Decree-laws that affected the financial sphere. The object of this study is the analysis of said normative instrument and its constitutional fit when modifying the tax laws within the aforementioned state of alarm.

:CIENCIAS JURÍDICAS [UNESCO]Real decreto-leyTax obligationsState of alarmUNESCO::CIENCIAS JURÍDICASObligaciones tributariasEstado de alarmaCOVID-19ECONOMIA FINANCIERA Y CONTABILIDADRoyal decree-law
researchProduct

Los programas de cumplimiento penal : Aspectos generales

2021

In Spain, as in many other countries, corporate criminal liability has been a reality for years, as well as criminal compliance programs that allow them to be mitigated or exonerated from liability. In this article we will present some of the main keys to consider for the implementation of these mechanisms. This is a series of general considerations that can serve as a guide to understand the complex system of crime prevention provided by the organization and management models in the corporate environment.

:CIENCIAS JURÍDICAS [UNESCO]responsabilidad penal de las personas jurídicas.self-regulationJosé In Spain2070-8157 22082 Revista Boliviana de Derecho 565487 2021 31 7730062 Los programas de cumplimiento penal Aspectos generales León Alapontas in many other countriesComputingMilieux_LEGALASPECTSOFCOMPUTINGCriminal compliance programsautorregulaciónUNESCO::CIENCIAS JURÍDICASas well as criminal compliance programs that allow them to be mitigated or exonerated from liability. In this article we will present some of the main keys to consider for the implementation of these mechanisms. This is a series of general considerations that can serve as a guide to understand the complex system of crime prevention provided by the organization and management models in the corporate environment. Programas de cumplimiento penalcorporate criminal liability 354 389corporate criminal liability has been a reality for years
researchProduct

Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.

2022

Funder: European Commission

ALTtype 2 diabetes mellitusROC receiving operator characteristicaspartate aminotransferaseHSDLDL low-density lipoproteinUHPLC ultrahigh-performance liquid chromatographyROCHCCNon-alcoholic steatohepatitisGCPCANASHGastroenterology2-HB 2-hydroxybutanoic acid; 3-HB 3-hydroxybutanoic acid; ALT alanine aminotransferase; AST aspartate aminotransferase; CE cholesterol ester; Cer ceramide; FFA free fatty acid; FLIP Fatty Liver Inhibition of Progression; Fibrosis; GC gas chromatography; HCC hepatocellular carcinoma; HSD honest significant difference; LC lipid cluster; LDL low-density lipoprotein; LM lipid and metabolite; LMC lipid metabolite and clinical variable; LPC lysophosphatidylcholine; Lipidomics; Mass spectrometry; Metabolomics; NAFL non-alcoholic fatty liver; NAFLD non-alcoholic fatty liver disease; NAS NASH activity score; NASH non-alcoholic steatohepatitis; NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network; NRR non-rejection rate; Non-alcoholic steatohepatitis; PC(O) ether PC; PC phosphatidylcholine; PCA principal component analysis; PE phosphatidylethanolamine; QTOFMS quadrupole-time-of-flight mass spectrometry; ROC receiving operator characteristic; SAF steatosis activity and fibrosis; SM sphingomyelin; T2DM type 2 diabetes mellitus; TG triacylglycerol; UHPLC ultrahigh-performance liquid chromatographySAFSAF steatosis activity and fibrosisLM lipid and metabolitehonest significant differenceHSD honest significant differenceTG triacylglycerolnon-rejection ratecholesterol esterPCPEGC gas chromatographyfree fatty acidFLIPNASH non-alcoholic steatohepatitisNIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research NetworkBIOMARKERST2DMPE phosphatidylethanolamineLDLlipidNAFLDFFA free fatty acid2-HBMetabolomicsNAFL non-alcoholic fatty liverLMCphosphatidylcholineScience & TechnologySM sphingomyelinGastroenterology & HepatologyMass spectrometryactivitynutritional and metabolic diseasesT2DM type 2 diabetes mellitusACIDSreceiving operator characteristicdigestive system diseasesquadrupole-time-of-flight mass spectrometryLC lipid clusterlow-density lipoproteinNAS2-HB 2-hydroxybutanoic acidNAS NASH activity scoreQTOFMSether PCNRRSCORING SYSTEMprincipal component analysisgas chromatographyLC2-hydroxybutanoic acidPROGRESSIONAST aspartate aminotransferaseLMPC phosphatidylcholinePC(O)MARKERSUHPLCsteatosisTOOLImmunology and AllergyINSULIN-RESISTANCECerSMFatty Liver Inhibition of Progressionhepatocellular carcinoma2-HB 2-hydroxybutanoic acid NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network NRR non-rejection rate Non-alcoholic steatohepatitis PC(O) ether PC PC phosphatidylcholine PCA principal component analysis PE phosphatidylethanolamine QTOFMS quadrupole-time-of-flight mass spectrometry ROC receiving operator characteristic SAF steatosis activity and fibrosis SM T2DM type 2 diabetes mellitus TG triacylglycerol UHPLC ultrahigh-performance liquid chromatographyultrahigh-performance liquid chromatographyCELPC3-HBNAFLnon-alcoholic fatty liverTGtriacylglycerolNRR non-rejection rateLife Sciences & BiomedicineNAFLD non-alcoholic fatty liver diseaseFLIP Fatty Liver Inhibition of Progressionalanine aminotransferasemetaboliteCer ceramideCE cholesterol estersphingomyelinlysophosphatidylcholineand fibrosisALT alanine aminotransferaseInternal MedicineceramideNational Institute of Digestive Diseases and Kidney NASH Clinical Research NetworkAST3-HB 3-hydroxybutanoic acidQTOFMS quadrupole-time-of-flight mass spectrometryPCA principal component analysisLPC lysophosphatidylcholineHepatologynon-alcoholic fatty liver diseaseand clinical variablePC(O) ether PC3-hydroxybutanoic acidFibrosisNASH activity scoreNIDDK NASH-CRNlipid clusterlipid and metabolitephosphatidylethanolamineLipidomicsLMC lipid metabolite and clinical variableFFAHCC hepatocellular carcinomaJHEP reports : innovation in hepatology
researchProduct

Giant hepatocellular adenoma as cause of severe abdominal pain: a case report

2007

Abstract The authors describe the case of a large hepatocellular adenoma diagnosed in a 30-year old woman who came to us complaining of acute pain in the upper abdominal quadrants. The patient had been taking an oral contraceptive pill for the last ten years. We present the clinical features, the diagnostic work-up and the treatment prescribed.

Abdominal painPathologyoral contraceptive agent EMTREE medical terms: abdominal painanamnesilcsh:Medicinecomputer assisted tomographyaspartate aminotransferaseSurgical oncologynuclear magnetic resonance imagingMedicine(all)oral contraceptionadultarticleGeneral MedicineAbdominal quadrantsfemalepriority journalhistopathologycontrast enhancementdisease severitymedicine.symptomEMTREE drug terms: alanine aminotransferasemedicine.medical_specialtyOral contraceptive pillcontrast mediummedicinediffusion weighted imagingcase reportfollow uphumanAcute painliver biopsydrug useliver lobectomybusiness.industryGeneral surgeryPublic healthlcsh:RechographyHepatocellular adenomaliver angiographymedicine.diseasetumor bleedinghuman tissueclinical featurenausea and vomitingbusinessaspartate aminotransferase blood levelliver adenomaalanine aminotransferase blood level
researchProduct

Phytosociology and ecology of deciduous forests in Tajikistan (Middle Asia)

2017

Aims: To present the first syntaxonomical classification for the mesophilous deciduous forests of the PamirAlai Mountains in Tajikistan with some remarks on its environmental gradients. Location: Tajikistan. Methods: Altogether 201 relevés were sampled between 2008‒2013 using the seven-degree cover-abundance scale of Braun-Blanquet. They were classified by the modified TWINSPAN method using the four-step interval scale with cutoff levels of 0%, 2%, 5% and 10% and total inertia as a measure of cluster heterogeneity. Diagnostic species were identified using the phi coefficient as a fidelity measure. Detrendended Correspondence Analysis was used to determine the relation between samples, veget…

Acero turkestanici-Juglandion regiae0106 biological sciencesTajikistanEcology (disciplines)phytosociologyMiddle asiaPlant Science010501 environmental sciences010603 evolutionary biology01 natural sciencespopuletea laurifolio-suaveolentisQuerco-Fagetea; syntaxonomysyntaxonomyquerco-fageteavegetation classification0105 earth and related environmental sciencesNerio-TamariceteaMiddle Asiapopulion afghanicaePhytosociologyAgroforestryEcologyPopuletea laurifolio-suaveolentisacero turkestanici-juglandion regiaePamir Alai MtsPamir Alai Mts.GeographyDeciduousPopulion afghanicaedecidous forest
researchProduct

Psychosocial adjustment in patients surgically treated for laryngeal cancer.

2003

Abstract Objective To assess the psychosocial adjustment in 62 patients surgically treated for cancer of the head and neck. Study design and setting Forty-one patients were grouped as having had radical surgery (total laryngectomy) and 21 as having had functional surgery (horizontal supraglottic laryngectomy or partial vertical surgery). The Psychosocial Adjustment to Illness Scale-Self Report (PAIS-SR) was used for the evaluation. Results No significant differences were found between groups when global adjustment or domain adjustment was compared. Patients did not consider the permanent stoma and voice loss to be the most important determinant of quality of life. Work and family relationsh…

AdultEmploymentMalemedicine.medical_specialtymedicine.medical_treatmentLaryngectomyStomaQuality of lifeAdaptation PsychologicalmedicineHumansPhonationRadical surgeryLaryngeal NeoplasmsAgedAged 80 and overRehabilitationbusiness.industryCancerSocial SupportMiddle Agedmedicine.diseaseLaryngectomySpeech AlaryngealOtorhinolaryngologyPhysical therapyQuality of LifeSurgeryFemaleFamily RelationsbusinessPsychosocialSocial AdjustmentOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
researchProduct