Search results for " Alan"
showing 10 items of 58 documents
EPR ANALYSIS OF ALANINE WITH GADOLINIUM FOR DOSIMETRY AT TRIGA MARK II REACTOR OF MAINZ
2015
Negli ultimi anni il crescente interesse verso la radioterapia a cattura neutronica (internazionalmente nota come Neutron Capture Therapy - NCT) per il trattamento di neoplasie ha stimolato diverse attività di ricerca finalizzate alla caratterizzazione del fascio utilizzato e all'ottimizzazione delle procedure radioterapiche. La corretta riuscita del trattamento NCT e il monitoraggio della dose impartita non possono prescindere dalla valutazione delle varie componenti del fascio impiegato (neutronica e fotonica). Infatti, durante le procedure di moderazione dei neutroni, si verifica la produzione di fotoni e la stima dei rischi a cui sono soggetti i tessuti sani sottoposti al campo misto ne…
Determination of gamma component in thermal column of Pavia Triga reactor by using alanine ESR detectors
2014
ALANINE/EPR DOSIMETRY APPLIED TO THE VALIDATION OF A TOTAL BODY IRRADIATION (TBI) PROTOCOL AND TREATMENT PLANNING DOSE CALCULATION USING A HUMANOID P…
2015
L’irraggiamento a corpo intero (Total Body Irradiation - TBI) è una tecnica di radioterapia oncologica di largo impiego nella clinica ematoncologica nell’ambito del trattamento di pazienti avviati al trapianto di midollo osseo o al trapianto di cellule staminali periferiche. La TBI da una parte permette di sopprimere il sistema immunitario del ricevente per prevenire il rigetto del midollo del donatore ed eliminare le cellule neoplastiche residue dai trattamenti chemioterapici. In genere, la modalità di somministrazione della TBI prevede irraggiamenti in 3 giorni consecutivi con un bi-frazionamento giornaliero (2 Gy, 2 volte al giorno con intervallo minimo di 6 ore tra le sedute, per 3 gior…
EPR DOSIMETRY WITH ALANINE FOR TOTAL BODY IRRADIATION USING AN ANTHROPOMORPHIC PHANTOM
2016
The Total Body Irradiation (TBI) is a radiation therapy technique widely used in clinical hemato-oncological treatment of patients that underwent bone marrow transplantation or peripheral stem cell transplantation. Typically, the administration of TBI treatment provides irradiations in 3 consecu-tive days with a double daily fractionation, although other dose fractionation modes have been widely adopted in the clinic procedures. Although this tech-nique allows to irradiate the whole body from head to toes, it has some limitations such as the lack of homogeneity of the dose distribution (which can show varia-tions of 20% in the different areas), irradiation of critical organs such as lungs, …
EPR/alanine dosimetry for verification in Helical Tomotherapy Stereotactic Radiosurgery (HTSRS) treatments
2018
Introduction Intracranial stereotactic radiosurgery (SRS) is a technique to deliver an ablative radiation dose with an extremely sharp dose gradient to small brain tumors. In this study the accuracy of the dose delivered in SRS by a non conventional radiotherapy machine, the TomoTherapy Hi-Art System, was investigated using an "end-to-end" test using alanine pellets and gafchromic films. Methods Dose verifications were made using alanine dosimeters placed in an antropomorphic head phantom (Alderson Rando Phantom) under different treatment conditions in case of both single and multiple brain tumors. 1.25mm slice kVCT scan of the phantom was used to generate SRS plans on the TomoTherapy Plann…
Nuevo Orden Mundial. Narraciones sobre el poder y superhéroes en el cómic mainstream estadounidense de Stormwatch a Black Summer (1996-2008)
2009
Los cómics de superhéroes han sido estudiados por la crítica, sobre todo, como artefactos mitológicos de implicaciones morales y filosóficas. Pero desde finales de los noventa una parte importante del cómic de superhéroes mainstream se ha convertido en una narrativa simbólica sobre el poder en el mundo contemporáneo, alimentándose del discurso y los acontecimientos políticos, textualizando de manera sutil, política y moralmente provocadora, acontecimientos reales como el nuevo terrorismo y las respuestas militares a éste, la polarización de la vida política americana o el (des)equilibrio de poder mundial. Este estudio de la producción de Warren Ellis y Mark Millar muestra la importancia de …
The 3'-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing …
2003
The expression of the major protein kinase C substrate MARCKS (myristoylated alanine-rich C kinase substrate) is controlled by the stability of its mRNA. While the MARCKS mRNA is long living in quiescent fibroblasts (t1/2 = 14 h), its half-life time is drastically reduced (t1/2 = 2 h) in cells treated with phorbol esters to activate protein kinase C (PKC) or treated with growth factors. In a first step to study the underlying mechanism we identified both a cis-element on the MARCKS mRNA and the corresponding trans-acting factors. Fusing the complete 3'-UTR or specific regions of the 3'-UTR of the MARCKS gene to a luciferase reporter gene caused a drastic decrease in luciferase expression to…
Programme-cadre FENOIR (Figurations de l’environnement nocturne des territoires réunionnais). Rapport d’étape pour le Parc national de La Réunion
2022
Soumise à une importante poussée démographique, l’île de La Réunion a vu sa population urbaine fortement augmenter – passant de 44 % de la population totale en 1975 à 95 % en 2015. Directement corrélée aux formes et dynamiques spatiales de l’urbanisation, l’empreinte lumineuse sur l’île a connu une mutation radicale ces dernières années : son emprise et sa pression ont considérablement augmenté sur l’ensemble du territoire, depuis la côte jusqu’à l’intérieur même du Parc national de La Réunion qui recouvre plus de 76 % du territoire insulaire (42 % pour la zone cœur). Acteur incontournable des enjeux environnementaux sur l’île, le Parc national a mené très tôt des actions autour des effets …
Un precursore delle nuove tendenze del cinema musicale
2011
The Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) is Sequentially Phosphorylated by Conventional, Novel and Atypical Isotypes of Protein Kin…
1995
The myristoylated alanine-rich C-kinase substrate (MARCKS) is the major protein kinase C (PKC) substrate in many cell types including fibroblasts and brain cells. Here we describe the phosphorylation of MARCKS and the site specificity for different PKC isotypes. Conventional (c)PKC beta 1, novel (n)PKC delta and nPKC epsilon efficiently phosphorylated the MARCKS protein in vitro. The Km values were extremely low, reflecting a high affinity between kinases and substrate. The apparent affinity of nPKC delta (Km = 0.06 microM) was higher than that of nPKC epsilon and cPKC beta 1 (Km = 0.32 microM). The rate of substrate phosphorylation was inversely correlated with affinity and decreased in th…