Search results for " Analysis of Variance"

Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma.

2019

Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration. In this light, we aimed to examine the genetic heterogeneity of GBM and to correlate it with the clinical characteristics of the patients. For that purpose, we analyzed the status of EGFR and the somatic copy number alterations (CNAs) of a set of tumor suppressor genes and oncogenes. Thus, we found GBMs with high level of EGFR amplification, low level and with no EGFR amplification. Highly amplified tumors showed histological features of…

Energy spectral density as valid parameter to compare postural control between subjects with nonspecific chronic low back pain vs healthy subjects : …

2021

Abstract Background Nonspecific chronic low back pain (NSCLBP) is one of the most common and frequent health problems. Objetive to compare postural control (i.e. center of pressure (CoP) displacement and energy spectral density (ESD)) using technological devices (accelerometers and pressure platform) between subjects with NSCLBP and healthy subjects. Methods A cross-sectional case-control study was conducted. Observational study (STROBE). The final sample consisted of 60 subjects (30 NSCLBP subjects and 30 healthy subjects). Triaxial accelerometer and pressure platform were used in order to obtain ESD and CoP displacement measurements during four balance tasks (i.e. with and without vision …

Socioemotional behavior and school achievement in relation to extracurricular activity participation in middle childhood

2012

This 3-year longitudinal study investigated the associations of student (aged 9 to 10 years at the beginning of the study; n = 281; 51% girls) participation in extracurricular activities with teacher-rated socioemotional behavior and school achievement. MANOVA results showed that, after controlling for the grade level and the initial level of the outcome variables, participation in arts and crafts and music activities was related to higher adaptive behavior, academic attainments (i.e., reading, writing, arithmetic), and working skills (persistence, concentration, carefulness). Participation in performing arts was associated with higher academic working skills, and participation in academic …

Incidencia de factores personales y contextuales sobre el uso de los recursos tecnológicos por el alumnado en América Latina

2021

El uso de las tecnologías de la información y de la comunicación (TIC) por parte de alumnado refleja si el proceso de integración es apropiado. No obstante, la tipología de uso de las TIC en el alumnado no se ha establecido de forma empírica en función de su uso en casa y el centro educativo. Así, el propósito del artículo es determinar la estructura del uso de las TIC por parte del alumnado, junto con la influencia de factores personales y contextuales. Se ha empleado un diseño correlacional, siendo la muestra el alumnado de sexto curso de América Latina que ha respondido al cuestionario sobre uso de las TIC en el Tercer Estudio Regional Comparativo y Explicativo (TERCE). El análisis de da…

On hidden heterogeneity in directional asymmetry – can systematic bias be avoided?

2006

8 pages; International audience; Directional asymmetry (DA) biases the analysis of fluctuating asymmetry (FA) mainly because among-individual differences in the predisposition for DA are difficult to detect. However, we argue that systematic bias mainly results from predictable associations between signed right-left asymmetry and other factors, i.e. from systematic variation in DA. We here demonstrate methods to test and correct for this, by analysing bilateral asymmetry in size and shape of an irregular sea urchin. Notably, in this model system, DA depended significantly on body length and geographic origin, although mean signed asymmetry (mean DA) was not significant in the sample as a wh…

Efecto moderador de la institucionalización en las actividades de la vida diaria y bienestar en el envejecimiento

2012

OBJETIVO: El envejecimiento con éxito es un concepto multidimensional que se puede evaluar a partir de componentes objetivos y subjetivos como el funcionamiento físico, psicológico y social. El objetivo de este trabajo es comparar el funcionamiento en variables relacionadas con el envejecimiento exitoso en ancianos institucionalizados y no institucionalizados. MÉTODO: Se realizó un diseño de dos grupos independientes, institucionalizados (N=242) y no institucionalizados (N=607), todos de más de 65 años, evaluándose sus actividades de la vida diaria (AVD) y el bienestar psicológico. RESULTADOS: El Índice de Barthel mostró diferencias significativas, siendo inferior la media de los institucio…

School adjustment in children who stutter: The quality of the student-teacher relationship, peer relationships, and children's academic and behaviora…

2020

Abstract Introduction The aim of this study was to investigate the quality of the student-teacher relationship, peer relationship, emotional and behavioral outcomes and academic performance in school adjustment of children who stutter. Methods The convenience sample consisted of 536 children – 62 affected by stuttering and 474 in the control group – and 36 prevalent teachers from six primary and secondary schools in Northwest Italy. Children were assessed with a sociometric questionnaire. Teacher evaluations were also used to assess their perception of their relationships with the student (Student-Teacher Relationship Scale), children’ behavior (Strengths and Difficulties Questionnaire), an…

2020

Background Small sample sizes combined with multiple correlated endpoints pose a major challenge in the statistical analysis of preclinical neurotrauma studies. The standard approach of applying univariate tests on individual response variables has the advantage of simplicity of interpretation, but it fails to account for the covariance/correlation in the data. In contrast, multivariate statistical techniques might more adequately capture the multi-dimensional pathophysiological pattern of neurotrauma and therefore provide increased sensitivity to detect treatment effects. Results We systematically evaluated the performance of univariate ANOVA, Welch’s ANOVA and linear mixed effects models …

On the Estimation of the Volatility-Growth Link

2012

It is common practice to estimate the volatility-growth link by specifying a standard growth equation such that the variance of the error term appears as an explanatory variable in this growth equation. The variance in turn is modeled by a second equation. Hardly any of existing applications of this framework includes exogenous controls in this second variance equation. Our theoretical findings suggest that the absence of relevant explanatory variables in the variance equation leads to a biased and inconsistent estimate of the volatility-growth link. Our simulations show that this effect is large. Once the appropriate controls are included in the variance equation consistency is restored. I…

Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk.

2014

Beta-amyloid accumulation in brain is a driving force for Alzheimer's disease pathogenesis. Apolipoprotein E (ApoE) represents a critical player in beta-amyloid homeostasis, but its role in disease progression is controversial. We previously reported that the acute-phase protein haptoglobin binds ApoE and impairs its function in cholesterol homeostasis. The major aims of this study were to characterize the binding of haptoglobin to beta-amyloid, and to evaluate whether haptoglobin affects ApoE binding to beta-amyloid. Haptoglobin is here reported to form a complex with beta-amyloid as shown by immunoblotting experiments with purified proteins, or by its immunoprecipitation in brain tissues …