Search results for " Anatomia"

Perinatal stem cells revisited: directions and indications at the crossroads between tissue regeneration and repair.

2013

Perinatal stem cells research attracted great interest worldwide in recent years. Foetus-associated tissues contain various populations of stem cells, most of which are comprised within the category of mesenchymal stem cells (MSCs). This special issue collects both reviews and original reports on all the perinatal stem cell types which are currently under investigation. These cells have multiple promising features: differentiative capacity towards mature cell types of all the three germ layers, hypoimmunogenicity in vitro and in vivo, ease of sourcing, ex vivo culture and stor- age. In particular, immune modulation is viewed as a prom- ising feature of many MSCs populations, since these cel…

Mining extraction in the ocean depths: a baseline to understand and reduce acoustic impact on biodiversity.

2020

[ES] A lo largo de la historia, el hombre ha explotado los recursos minerales de la tierra para su supervivencia y desarrollo tecnológico sin un equilibrio con su regeneración. Dado el crecimiento de la población mundial y la reducción de recursos, el hombre comenzó a buscar nuevos depósitos que se encontraron en la década de 1960 en las profundidades de los océanos. Con estos, la humanidad empezò a pensar en extraer los minerales de estos depósitos y esto llevò al nacimiento de Deep Sea Mining (DSM). Las consecuencias de las actividades mineras en las profundidades del mar no se conocen realmente y los efectos pueden ser diferentes: contaminación acústica, contaminación lumínica, contamina…

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

2016

Seuls les 100 premiers auteurs dont les auteurs INRA ont été entrés dans la notice. La liste complète des auteurs et de leurs affiliations est accessible sur la publication.; International audience; In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues…

DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging

2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19), known to be more common in the elderly, who also show more severe symptoms and are at higher risk of hospitalization and death. Here, we show that the expression of the angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 cell receptor, increases during aging in mouse and human lungs. ACE2 expression increases upon telomere shortening or dysfunction in both cultured mammalian cells and in vivo in mice. This increase is controlled at the transcriptional level, and Ace2 promoter activity is DNA damage response (DDR)-dependent. Both pharmacological global DDR inhibition of ATM kin…

EFFECTS OF ACUSTIC STRESS ON BIOCHEMICAL AND MOBILITY PARAMETERS AND BEHAVIOUR IN THE CRAYFISH, CHERAX DESTRUCTOR

2022

Biological responses to high-frequency sound in a freshwater crayfish, Cherax quadricarinatus

2023

Anthropogenic noise is recognised as an important environmental stressor that can have longterm negative consequences on species. In recent years, there has been increasing attention to the potential negative impact of noise pollution on species, with great concern for the importance of impacts on aquatic animal life. This study examined the effects of acoustic stress on the biochemical parameters of the freshwater crayfish Cherax quadricarinatus. The experiment was conducted in a tank equipped with an audio and video recording system using ten groups (five control and five test) of three adult crayfish (30 animals in total). The animals in the test group were exposed to acoustic signals [a…

Aspects of osteogenic and adipogenic differentiation of adult mesenchymal stem cells

2012

ANATOMIA DELL'APPARATO STOMATOGNATICO E DELLE STRUTTURE VICINIORI

2008

Il presente compendio è una riedizione, rivista ed integrata di nuovi capitoli del manuale ”L’apparato buccofaringeo e le strutture ad esso correlate” di V. Valenza edito da Medical Book 1998. Le principali integrazioni hanno riguardato soprattutto i capitoli relativi al cranio, all’articolazione temporo mandibolare e all’innervazione del distretto oro faringeo. Dei capitoli aggiunti, uno è stato dedicato ai denti e l’altro ad argomenti di anatomia pratica. La parte iconografica è stata arricchita di numerose nuove figure originali di cui diverse realizzate dal vivo per rendere più “animata” la trattazione; sono stati aggiunti anche nuovi schemi e tabelle. Si auspica che quanto realizzato p…

Hsp60, a Novel Target for Antitumor Therapy: Structure-Function Features and Prospective Drugs Design

2013

Heat shock protein 60 kDa (Hsp60) is a chaperone classically believed to be involved in assisting the correct folding of other mitochondrial proteins. Hsp60 also plays a role in cytoprotection against cell stressors, displaying for example, antiapoptotic potential. Despite the plethora of studies devoted to the mechanism of Hsp60's function, especially in prokaryotes, fundamental issues still remain unexplored, including the definition of its role in cancer. Key questions still unanswered pertain to the differences in structure-function features that might exist between the well-studied prokaryotic GroEL and the largely unexplored eukaryotic Hsp60 proteins. In this article we discuss these …

Rapid changes in heat-shock cognate 70 levels, heat-shock cognate phosphorylation state, heat-shock transcription factor, and metal transcription fac…

2010

The aim of the present study was to analyze and compare the effects of several metals on the embryos of the sea urchin Paracentrotus lividus, a key species within the Mediterranean Sea ecosystem. Embryos were continuously exposed from fertilization to the following metals: 0.6 mg/l copper, 3 mg/l lead, and 6 mg/l nickel. The embryos were then monitored for metal responses at the gastrula stage, which occurred 24 h after exposure. A biochemical multi-experimental approach was taken and involved the investigation of the levels of HSC70 expression and the involvement of heat shock factor (HSF) and/or metal transcription factor (MTF) in the response. Immunoblotting assays and electrophoretic mo…