Search results for " Animals"
showing 10 items of 703 documents
Milk quality as affected by grazing time of day in Mediterranean goats.
2008
We evaluated the effect of grazing time of day on goat milk chemical composition, renneting properties and milk fatty acid profile in a Mediterranean grazing system. Sixteen lactating Girgentana goats were divided into two experimental groups and housed in individual pens, where they received 500 g/d of barley grain. For 5 weeks the two groups were left to graze in two fenced plots on a ryegrass sward as follows: morning group (AM), from 9·00 to 13·00; afternoon group (PM), from 12·00 to 16·00. In selected herbage, water-soluble carbohydrates (WSC) increased in the afternoon (204 v. 174 g/kg dry matter, DM; P=0·01), whereas crude protein (CP) and linolenic acid decreased (respectively, 16·7…
La qualità dell’aria indoor: una priorità ambientale e sanitaria
2009
The stable repression of mesenchymal program is required for hepatocyte identity: A novel role for hepatocyte nuclear factor 4α
2011
The concept that cellular terminal differentiation is stably maintained once development is complete has been questioned by numerous observations showing that differentiated epithelium may undergo an epithelial-to-mesenchymal transition (EMT) program. EMT and the reverse process, mesenchymal-to-epithelial transition (MET), are typical events of development, tissue repair, and tumor progression. In this study, we aimed to clarify the molecular mechanisms underlying these phenotypic conversions in hepatocytes. Hepatocyte nuclear factor 4α (HNF4α) was overexpressed in different hepatocyte cell lines and the resulting gene expression profile was determined by real-time quantitative polymerase…
An epistatic mini-circuitry between the transcription factors Snail and HNF4α controls liver stem cell and hepatocyte features exhorting opposite reg…
2011
Preservation of the epithelial state involves the stable repression of epithelial-to-mesenchymal transition program, whereas maintenance of the stem compartment requires the inhibition of differentiation processes. A simple and direct molecular mini-circuitry between master elements of these biological processes might provide the best device to keep balanced such complex phenomena. In this work, we show that in hepatic stem cell Snail, a transcriptional repressor of the hepatocyte differentiation master gene HNF4α, directly represses the expression of the epithelial microRNAs (miRs)-200c and-34a, which in turn target several stem cell genes. Notably, in differentiated hepatocytes HNF4α, p…
TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling
2007
The epithelial-to-mesenchymal transition (EMT) is a crucial process, occurring both during development and tumor progression, by which an epithelial cell undergoes a conversion to a mesenchymal phenotype, dissociates from initial contacts and migrates to secondary sites. We recently reported that in hepatocytes the multifunctional cytokine TGFβ induces a full EMT characterized by (i) Snail induction, (ii) E-cadherin delocalization and down-regulation, (iii) down-regulation of the hepatocyte transcriptional factor HNF4α and (iv) up-regulation of mesenchymal and invasiveness markers. In particular, we showed that Snail directly causes the transcriptional down-regulation of E-cadherin and HN…
Functional genomics of Lactobacillus casei establishment in the gut
2014
International audience; Although the composition of the gut microbiota and its symbiotic contribution to key host physiological functions are well established, little is known as yet about the bacterial factors that account for this symbiosis. We selected Lactobacillus casei as a model microorganism to proceed to genomewide identification of the functions required for a symbiont to establish colonization in the gut. As a result of our recent development of a transposon-mutagenesis tool that overcomes the barrier that had prevented L. casei random mutagenesis, we developed a signature-tagged mutagenesis approach combining whole-genome reverse genetics using a set of tagged transposons and in…
Los canecillos de la Capilla del Cementerio de San Juan del Hospital de Valencia
2020
In the medieval cemetery of the Historic Site of San Juan del Hospital of Valencia is housed a small funeral chapel founded in the late thirteenth century by the knight Arnau de Romaní. Along its cornice there are a series of heads of animals and humans that are one of the few sculptural vestiges inserted into the Romanesque iconographic tradition that are preserved in the city. So far they have not aroused the interest of specialists and no one has dedicated a detailed study to these curious and interesting images located in the marginal spaces of such a beautiful building. This article aims to complete this gap addressing the study of the corbels of the small temple, projecting a thematic…
Valutazione ex-post degli incentivi alle imprese nelle economie territoriali: nuovi sviluppi
2015
[No abstract available]
La pianificazione strategica nelle città del Mezzogiorno
2014
Un programma di incentivi lanciato nel 2004 dal governo nazionale ha consentito a diverse decine di municipalità del Mezzogiorno di avviare la costruzione di piani strategici per promuovere nuovi scenari di sviluppo sostenibile per le proprie aree urbane e metropolitane. Rispetto a questo quadro di esperienze ancora in corso di implementazione, questo articolo si propone due obiettivi: i) descrivere i modelli di governance adottati nelle diverse regioni del Mezzogiorno e, attraverso questi, com- prendere il contributo che i piani strategici possono fornire alle politiche territoriali regionali; ii) identificare alcune condizioni di efficacia per l’implementazione dei piani strategici in con…
Effetti spaziali o settoriali? La crescita della dimensione media d'impresa in Italia
2015
Utilizzando una recente versione della shift-share con struttura spaziale, in questo contributo scomponiamo il cambiamento della dimensione media delle imprese nelle province italiane rispetto a componenti di natura sia spaziale (di regione e di vicinato) che settoriale. L’analisi, condotta con riferimento al periodo 2004-2009, mette in risalto differenze di rilievo rispetto la classe dimensionale considerata. In particolare, si registra una netta demarcazione Nord-Sud nella distribuzione provinciale degli effetti spaziali e settoriali se consideriamo le micro imprese (1-10 addetti), mentre la geografia appare molto piu complessa per le piccole imprese (11-50 addetti).