Search results for " Antimicrobial"
showing 7 items of 117 documents
Alimentary and Pharmaceutical Approach to Natural Antimicrobials against Clostridioides difficile Gastrointestinal Infection
2021
Incidence of Clostridioides difficile infection (CDI) has been increasing in recent decades due to different factors, namely (i) extended use of broad-spectrum antibiotics, (ii) transmission within asymptomatic and susceptible patients, and (iii) unbalanced gastrointestinal microbiome and collateral diseases that favor C. difficile gastrointestinal domination and toxin production. Although antibiotic therapies have resulted in successful control of CDI in the last 20 years, the development of novel strategies is urged in order to combat the capability of C. difficile to generate and acquire resistance to conventional treatments and its consequent proliferation. In this regard, vegetable and…
CH vs. HC—Promiscuous Metal Sponges in Antimicrobial Peptides and Metallophores
2023
Histidine and cysteine residues, with their imidazole and thiol moieties that deprotonate at approximately physiological pH values, are primary binding sites for Zn(II), Ni(II) and Fe(II) ions and are thus ubiquitous both in peptidic metallophores and in antimicrobial peptides that may use nutritional immunity as a way to limit pathogenicity during infection. We focus on metal complex solution equilibria of model sequences encompassing Cys–His and His–Cys motifs, showing that the position of histidine and cysteine residues in the sequence has a crucial impact on its coordination properties. CH and HC motifs occur as many as 411 times in the antimicrobial peptide database, while …
Bivalve genomics used for characterization of the immune defense against microbial infections in mussel
2010
Bacterial biofilms: a challenge in the discovery of new anti-infective agents.
2010
The ability to form a biofilm, bacterial communities able to grow on surfaces and surrounded by an extracellular polymeric substance biofilm agents.Our research group focused on discovering of novel chemical agents of potential therapeutic utility in the treatment of staphylococcal biofilm-associatedinfections by screening novel compounds (synthetic or natural). In a recent study, the antistaphylococcalbiofilm activity of pyrrolomycins C,D, F1, F2a, F2b, F3 a family of halogenated pyrroles which are naturally produced byActinosporangium vitaminophylum and of the synthesized related compounds I, II, III were investigated and compared (Schillaci et al, 2010). We also focused on marine inverte…
Immunolocalization of an antimicrobial peptide in Ciona intestinalis (Tunicata ) tunic
2009
Doslidžennâ bìologìčnoï aktivnostìvtorinnogo ekstraktu zì šrotu travimaterinki zvičajnoï (Origanum vulgare)
2015
Studied the antimicrobial activity of secondary extract from oregano herbs waste (Origanum vulgare)against 7 standard test strains of microrganisms. Minimum bactericidal concentration of the extract to Staphylococcus aureus ATCC 6538 P-is 3.125-6.25 mg/ml and 6.25-12.5 mg/ml to gram-negative bacteria and Candida albicans ATCC 10231.Total antioxidant activity determined by DPPH, secondary extract at a concentration of 400 ug/ml was 92 %. The tested extract had photoprotective activity. Obtained results confirm the perspective of using waste of oregano herbs for making extracts and creation on their basis of pharmaceuticals, veterinary drugs and cosmetics.
αβ defensin antimicrobial peptide (BPDEF) from the invasive red sea mussel Brachidontes pharaonis (P. Fischer, 1870)
2015
The immune system that plays a major role in determining host fitness in the wild, i.e. under the constraints imposed by ecology and life history. Permanent conflict interactions with the environment are the natural situation for a living creature. To partially resolve this, the immune system evolved and is characterized by an enormous variety of mechanisms and effectors, including the AMPs, although their specificity is poor. In fact, AMPs are universal and extremely successful in dealing with a huge range of pathogens, including bacteria, fungi, protozoa and viruses Amps are oligopeptides composed of varying number of amino acids with a broad spectrum of targeted organisms ranging from vi…