Search results for " Aortic valve"

showing 10 items of 81 documents

Focus on the unique mechanisms involved in thoracic aortic aneurysm formation in bicuspid aortic valve versus tricuspid aortic valve patients: clinic…

2013

OBJECTIVES: The involvement of different factors in the onset of thoracic aortic aneurysm (TAA) in patients with a bicuspid aortic valve (BAV) vs those with a tricuspid aortic valve (TAV) is well recognized. However, the molecular, genetic and cellular mechanisms driving TAA remain unclear. The aim of this study was to identify the different mechanisms involved in TAA development in patients with BAV vs TAV. METHODS: Aorta specimens and DNA samples were collected from 24 BAV (18 men and 6 women; mean age: 54.2 ± 14.39 years) and 110 TAV (79 men and 31 women, mean age: 66 ± 9.8 years) patients. A control group of 128 subjects (61 men and 67 woman, mean age: 61.1 ± 5.8 years) was also enrolle…

Aortic valveMaleThoracicHeart Valve DiseasesApoptosisPilot ProjectsBicuspid aortic valve; Clinical implications; Identifying different genetic and histological profiles; Thoracic aortic aneurysm; Tricuspid aortic valve; Adult; Aged; Aortic Aneurysm Thoracic; Aortic Valve; Apoptosis; Comorbidity; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heart Valve Diseases; Histocytochemistry; Humans; Male; Matrix Metalloproteinase 9; Middle Aged; Pilot Projects; Polymorphism Single Nucleotide; Risk Factors; Tricuspid ValveComorbidityBicuspid aortic valveBicuspid Aortic Valve DiseaseGene FrequencyFibrosisRisk FactorsClinical implicationsTricuspid valvebiologyHistocytochemistryGeneral MedicineSingle NucleotideMiddle AgedAortic Aneurysmmedicine.anatomical_structureMatrix Metalloproteinase 9Aortic ValveCardiologyFemaleTricuspid ValveCardiology and Cardiovascular MedicinePulmonary and Respiratory MedicineAdultmedicine.medical_specialtyBicuspid aortic valveGenotypeThoracic aortic aneurysmTricuspid aortic valvePolymorphism Single Nucleotidemedicine.arteryInternal medicineThoracic aortic aneurysmAscending aortamedicineSettore MED/05 - Patologia ClinicaHumansGenetic Predisposition to DiseasePolymorphismIdentifying different genetic and histological profilesAgedAortaAortic Aneurysm Thoracicbusiness.industryAngiotensin-converting enzymeSettore MED/23 - Chirurgia Cardiacamedicine.diseasebiology.proteinSurgerybusinessEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
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Outcomes of aortic valve repair according to valve morphology and surgical techniques

2012

OBJECTIVES: The aim of this study was to assess the impact of aortic valve morphology and different surgical aortic valve repair techni- ques on long-term clinical outcomes. METHODS: Between February 2003 and May 2010, 216 patients with aortic insufficiency underwent aortic valve repair in our institu- tion. Ages ranged between 26 and 82 years (mean 53 ± 15 years). Aortic valve dysfunctions, according to functional classification, were: type I in 55 patients (25.5%), type II in 126 (58.3%) and type III in 35 (16.2%). Sixty-six patients (27.7%) had a bicuspid valve. Aortic valve repair techniques included sub-commissural plasty in 138 patients, plication in 84, free-edge reinforcement in 80,…

Aortic valveMaleTime Factorsmedicine.medical_treatmentKaplan-Meier EstimateAortic valve repairRecurrenceRisk FactorsMitral valve80 and overHospital MortalityCoronary Artery BypassAortaUltrasonographyAged 80 and overTricuspid valveCalcinosisCardiac Valve AnnuloplastyMiddle AgedAortic valve repair • Bicuspid aortic valve • Tricuspid aortic valve • Aortic annulus stabilization medicine.anatomical_structureTreatment OutcomeAortic ValveReplantationcardiovascular systemCardiologyChordae TendineaeMitral ValveFemaleChordae tendineaeCardiology and Cardiovascular MedicineAdult; Aged; Aged 80 and over; Aorta; Aortic Valve; Aortic Valve Insufficiency; Blood Vessel Prosthesis Implantation; Calcinosis; Chordae Tendineae; Coronary Artery Bypass; Disease-Free Survival; Female; Hospital Mortality; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Mitral Valve; Proportional Hazards Models; Recurrence; Replantation; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Ultrasonography; Cardiac Valve Annuloplasty; Suture TechniquesPulmonary and Respiratory MedicineAdultmedicine.medical_specialtyAortic Valve InsufficiencyRisk AssessmentCardiac Valve AnnuloplastyDisease-Free SurvivalBlood Vessel Prosthesis ImplantationBicuspid valveInternal medicinemedicineHumansAgedProportional Hazards ModelsMitral valve repairbusiness.industrySuture TechniquesSettore MED/23 - Chirurgia CardiacaOriginal ArticlesSurgerySurgerybusiness
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A multicentre European registry to evaluate the Direct Flow Medical transcatheter aortic valve system for the treatment of patients with severe aorti…

2016

Aims Our aim was to assess the clinical outcomes of the Direct Flow Medical Transcatheter Aortic Valve System (DFM-TAVS), when used in routine clinical practice. Methods and results This is a prospective, open-label, multicentre, post-market registry of patients treated with DFM-TAVS according to approved commercial indications. Echocardiographic and angiographic data were evaluated by an independent core laboratory and adverse events were adjudicated and classified according to VARC-2 criteria by an independent clinical events committee. The primary endpoint was freedom from all-cause mortality at 30 days post procedure. Secondary endpoints included procedural, early safety and efficacy en…

Aortic valveMalemedicine.medical_specialtyCardiac Catheterizationmedicine.medical_treatmentAortic Valve InsufficiencyRegurgitation (circulation)030204 cardiovascular system & hematologyTranscatheter Aortic Valve Replacement03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicinemedicineClinical endpointHumans030212 general & internal medicineHeart valveProspective StudiesRegistriesCardiac catheterizationAgedAged 80 and overHeart Valve Prosthesis Implantationbusiness.industryAortic Valve Stenosismedicine.disease3. Good healthClinical trialStenosismedicine.anatomical_structureTreatment OutcomeAortic valve stenosisAortic ValveHeart Valve ProsthesisCardiologyFemaleCardiology and Cardiovascular MedicinebusinessEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
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Difference in hemodynamic and wall stress of ascending thoracic aortic aneurysms with bicuspid and tricuspid aortic valve.

2012

The aortic dissection (AoD) of an ascending thoracic aortic aneurysm (ATAA) initiates when the hemodynamic loads exerted on the aneurysmal wall overcome the adhesive forces holding the elastic layers together. Parallel coupled, two-way fluid–structure interaction (FSI) analyses were performed on patient-specific ATAAs obtained from patients with either bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) to evaluate hemodynamic predictors and wall stresses imparting aneurysm enlargement and AoD. Results showed a left-handed circumferential flow with slower-moving helical pattern in the aneurysm's center for BAV ATAAs whereas a slight deviation of the blood flow toward the anterolater…

Aortic valveMalemedicine.medical_specialtyFluid–structure interaction Aortic dissection Ascending thoracic aortic aneurysm Bicuspid aortic valveBiomedical EngineeringBiophysicsHeart Valve DiseasesAorta ThoracicThoracic aortic aneurysmArticleAortic aneurysmBicuspid aortic valveBicuspid Aortic Valve DiseaseInternal medicinemedicine.arteryCoronary CirculationAscending aortamedicineThoracic aortaHumansOrthopedics and Sports Medicinecardiovascular diseasesAgedAortic dissectionAortabusiness.industryRehabilitationHemodynamicsModels CardiovascularMiddle Agedmedicine.diseaseElasticityAortic Aneurysmmedicine.anatomical_structureAortic ValveCardiologycardiovascular systemFemaleTricuspid ValvebusinessJournal of biomechanics
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Incidence, Predictive Factors, and Prognostic Impact of Silent Atrial Fibrillation After Transcatheter Aortic Valve Implantation.

2018

New onset atrial fibrillation post-transcatheter aortic valve implantation (TAVI) is common and is associated with adverse outcomes. However, silent atrial fibrillation (AF) is poorly documented in the context. This study sought to evaluate the incidence, predictive factors, and prognostic value of Silent AF post-TAVI. All the consecutive patients with TAVI were prospectively analyzed by continuous electrocardiogram monitoring≥48 hours after implantation. Silent AF was defined as asymptomatic episodes lasting at least 30 seconds. The population was divided into 3 groups: history of AF, no-AF, and silent AF. Among the 206 patients implanted with TAVI, 19 (16.1%) developed silent AF. Compared…

Aortic valveMalemedicine.medical_specialtyTime FactorsPopulationContext (language use)030204 cardiovascular system & hematologyAsymptomaticTranscatheter Aortic Valve Replacement03 medical and health sciencesElectrocardiography0302 clinical medicinePostoperative ComplicationsRisk FactorsInternal medicineAtrial FibrillationmedicineHumans030212 general & internal medicineProspective StudiesRegistriesProspective cohort studyeducationAged 80 and overeducation.field_of_studymedicine.diagnostic_testbusiness.industryIncidenceAtrial fibrillationAortic Valve Stenosismedicine.diseasePrognosismedicine.anatomical_structureAortic valve stenosisAortic ValveCardiologyFemaleFrancemedicine.symptomCardiology and Cardiovascular MedicinebusinessElectrocardiographyFollow-Up StudiesThe American journal of cardiology
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Transcatheter Heart Valve Implantation in Bicuspid Patients with Self-Expanding Device

2021

Bicuspid aortic valve (BAV) patients are conventionally not treated by transcathether aortic valve implantation (TAVI) because of anatomic constraint with unfavorable outcome. Patient-specific numerical simulation of TAVI in BAV may predict important clinical insights to assess the conformability of the transcathether heart valves (THV) implanted on the aortic root of members of this challenging patient population. We aimed to develop a computational approach and virtually simulate TAVI in a group of n.6 stenotic BAV patients using the self-expanding Evolut Pro THV. Specifically, the structural mechanics were evaluated by a finite-element model to estimate the deformed THV configuration in …

Aortic valveTechnologymedicine.medical_specialtybicuspid aortic valveQH301-705.5medicine.medical_treatment0206 medical engineeringDiastoleBioengineering02 engineering and technology030204 cardiovascular system & hematologyBicuspid aortic valve Finite-element analysis Fluid–solid interaction Transcatheter aortic valve implantationArticle03 medical and health sciences0302 clinical medicineBicuspid aortic valveInternal medicinemedicine.arterymedicineCardiac skeletonHeart valveBiology (General)transcatheter aortic valve implantationAortabusiness.industryTSettore ING-IND/34 - Bioingegneria IndustrialeStentmedicine.diseasefluid–solid interaction020601 biomedical engineeringAortic wallmedicine.anatomical_structurefinite-element analysiscardiovascular systemCardiologybusinessBioengineering
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TAVI imaging: over the echocardiography

2020

Aortic valve stenosis (AS) is a common valvular heart disease. Recently, transcatheter aortic valve implantation (TAVI) has changed the treatment of severe AS in elderly patients with contraindications to traditional surgical replacement. Echocardiography is conventionally used as the first imaging modality to assess the presence and severity of AS and to provide anatomical and functional information. Nowadays, imaging techniques play a crucial role in the planning of TAVI to define suitable candidates. Computed tomography (CT) is essential to display the anatomy of the aortic valve complex (including aortic annulus, Valsalva sinuses, coronary arteries ostia, sinotubular junction), thoracoa…

Aortic valvemedicine.medical_specialtyAortic valve stenosisCoronary Angiography030218 nuclear medicine & medical imagingTranscatheter Aortic Valve Replacement03 medical and health sciences0302 clinical medicineMagnetic resonance imagingmedicineHumansRadiology Nuclear Medicine and imagingCardiac skeletonComputed tomographyNeuroradiologyAgedIncidental FindingsTranscatheter aortic valve implantationmedicine.diagnostic_testbusiness.industryvalvular heart diseaseSettore ING-IND/34 - Bioingegneria IndustrialeMagnetic resonance imagingInterventional radiologyGeneral Medicinemedicine.diseaseCoronary arteriesmedicine.anatomical_structureEchocardiography030220 oncology & carcinogenesisAortic valve stenosiscardiovascular systemRadiologybusinessTomography X-Ray ComputedSettore MED/36 - Diagnostica Per Immagini E Radioterapia
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Bicuspid aortic valve and sports: From the echocardiographic evaluation to the eligibility for sports competition

2021

Bicuspid aortic valve (BAV) is the most common congenital heart defect in adults. Although a BAV may remain without clinical consequences for a lifetime, it can deteriorate in aortic valve stenosis and regurgitation and aortic dilatation. Unfortunately, the impact of regular training on patients with BAV and its natural course is not fully understood, although preliminary evidence suggests that the progression of valvular disease occurs primarily in an independent manner from sports practice. The current review aims to report how to perform a comprehensive echocardiographic examination in athletes with BAV and analyze the current literature on the influence of sports practice and how it imp…

Aortic valvemedicine.medical_specialtyCompetitive BehaviorEligibility DeterminationPhysical Therapy Sports Therapy and RehabilitationRegurgitation (circulation)030204 cardiovascular system & hematologyBicuspid Aortic Valve03 medical and health sciences0302 clinical medicineBicuspid aortic valveValvular diseaseBicuspid Aortic Valve DiseaseInternal medicinemedicineHumansOrthopedics and Sports MedicineEligibility DeterminationExerciseAortaAortic dilatationbiologybusiness.industryAthletes030229 sport sciencesbiology.organism_classificationmedicine.diseaseEchocardiography Dopplermedicine.anatomical_structureAortic valve stenosiscardiovascular systemCardiologybusinessDilatation PathologicPhysical Conditioning HumanSports
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Deep learning approach for the segmentation of aneurysmal ascending aorta.

2020

Diagnosis of ascending thoracic aortic aneurysm (ATAA) is based on the measurement of the maximum aortic diameter, but size is not a good predictor of the risk of adverse events. There is growing interest in the development of novel image-derived risk strategies to improve patient risk management towards a highly individualized level. In this study, the feasibility and efficacy of deep learning for the automatic segmentation of ATAAs was investigated using UNet, ENet, and ERFNet techniques. Specifically, CT angiography done on 72 patients with ATAAs and different valve morphology (i.e., tricuspid aortic valve, TAV, and bicuspid aortic valve, BAV) were semi-automatically segmented with Mimic…

Aortic valvemedicine.medical_specialtyComputer science0206 medical engineeringBiomedical Engineering02 engineering and technology01 natural sciencesThoracic aortic aneurysm010309 opticsAneurysmBicuspid aortic valvemedicine.artery0103 physical sciencesAscending aortamedicineSegmentationAortabusiness.industryDeep learningSettore ING-IND/34 - Bioingegneria Industrialemedicine.disease020601 biomedical engineeringAneurysm Aorta Aortic valve Deep learningSegmentationmedicine.anatomical_structureOriginal ArticleRadiologyArtificial intelligencebusinessBiomedical engineering letters
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Cost effectiveness of aortic valve therapies: a systematic review of the literature

2022

Background: Systematic review on the cost effectiveness of transcatheter aortic valve implantation (TAVI) to standard aortic valve replacement and medical management in high-risk elderly patients with severe aortic stenosis. Evidenced based systematic reviews are the core methodologies in health economics for evaluating cost effectiveness and medical effectiveness. Clarity and transparency of these reports can help to provide health care interventions accurately and reliably. Methods: In accordance with Preferred Reporting Items for Systematic reviews and Meta-Analyses, a systematic review on current literature for cost-effectiveness of TAVI, standard aortic valve replacement, and medical m…

Aortic valvemedicine.medical_specialtyCost effectivenessmedicine.medical_treatmentSettore MED/42 - Igiene Generale E ApplicataValve replacementAortic valve replacementsystematic reviewmedicinelcsh:R5-920Transcatheter aortic valve implantationcost effectivenessbusiness.industrylcsh:Public aspects of medicinelcsh:RA1-1270medicine.diseaseSurgeryQuality-adjusted life yearStenosisSystematic reviewmedicine.anatomical_structureAortic stenosis; Transcatheter aortic valve implantation; Cost effectiveness; Clinical effectiveness; Systematic reviewbusinesslcsh:Medicine (General)Incremental cost-effectiveness ratio
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