Search results for " Applications"

Mean-field games and dynamic demand management in power grids

2013

This paper applies mean-field game theory to dynamic demand management. For a large population of electrical heating or cooling appliances (called agents), we provide a mean-field game that guarantees desynchronization of the agents thus improving the power network resilience. Second, for the game at hand, we exhibit a mean-field equilibrium, where each agent adopts a bang-bang switching control with threshold placed at a nominal temperature. At equilibrium, through an opportune design of the terminal penalty, the switching control regulates the mean temperature (computed over the population) and the mains frequency around the nominal value. To overcome Zeno phenomena we also adjust the ban…

Reducing the effect of the data order in algorithms for constructing phylogenetic trees.

1988

Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds.

2022

The data currently described was generated within the EU/FP7 HeCaToS project (Hepatic and Cardiac Toxicity Systems modeling). The project aimed to develop an in silico prediction system to contribute to drug safety assessment for humans. For this purpose, multi-omics data of repeated dose toxicity were obtained for 10 hepatotoxic and 10 cardiotoxic compounds. Most data were gained from in vitro experiments in which 3D microtissues (either hepatic or cardiac) were exposed to a therapeutic (physiologically relevant concentrations calculated through PBPK-modeling) or a toxic dosing profile (IC20 after 7 days). Exposures lasted for 14 days and samples were obtained at 7 time points (therapeutic…

Horvitz-Thompson estimators for functional data: asymptotic confidence bands and optimal allocation for stratified sampling

2009

When dealing with very large datasets of functional data, survey sampling approaches are useful in order to obtain estimators of simple functional quantities, without being obliged to store all the data. We propose here a Horvitz--Thompson estimator of the mean trajectory. In the context of a superpopulation framework, we prove under mild regularity conditions that we obtain uniformly consistent estimators of the mean function and of its variance function. With additional assumptions on the sampling design we state a functional Central Limit Theorem and deduce asymptotic confidence bands. Stratified sampling is studied in detail, and we also obtain a functional version of the usual optimal …

Adaptive reference-free compression of sequence quality scores

2014

Motivation: Rapid technological progress in DNA sequencing has stimulated interest in compressing the vast datasets that are now routinely produced. Relatively little attention has been paid to compressing the quality scores that are assigned to each sequence, even though these scores may be harder to compress than the sequences themselves. By aggregating a set of reads into a compressed index, we find that the majority of bases can be predicted from the sequence of bases that are adjacent to them and hence are likely to be less informative for variant calling or other applications. The quality scores for such bases are aggressively compressed, leaving a relatively small number at full reso…

What we look at in paintings: A comparison between experienced and inexperienced art viewers

2016

How do people look at art? Are there any differences between how experienced and inexperienced art viewers look at a painting? We approach these questions by analyzing and modeling eye movement data from a cognitive art research experiment, where the eye movements of twenty test subjects, ten experienced and ten inexperienced art viewers, were recorded while they were looking at paintings. Eye movements consist of stops of the gaze as well as jumps between the stops. Hence, the observed gaze stop locations can be thought as a spatial point pattern, which can be modeled by a spatio-temporal point process. We introduce some statistical tools to analyze the spatio-temporal eye movement data, a…

Bayesian survival analysis with BUGS

2020

Survival analysis is one of the most important fields of statistics in medicine and biological sciences. In addition, the computational advances in the last decades have favored the use of Bayesian methods in this context, providing a flexible and powerful alternative to the traditional frequentist approach. The objective of this article is to summarize some of the most popular Bayesian survival models, such as accelerated failure time, proportional hazards, mixture cure, competing risks, multi-state, frailty, and joint models of longitudinal and survival data. Moreover, an implementation of each presented model is provided using a BUGS syntax that can be run with JAGS from the R programmin…

Reassessing Accuracy Rates of Median Decisions

2007

We show how Bruno de Finetti''s fundamental theorem of prevision has computable applications in statistical problems that involve only partial information. Specifically, we assess accuracy rates for median decision procedures used in the radiological diagnosis of asbestosis. Conditional exchangeability of individual radiologists'' diagnoses is recognized as more appropriate than independence which is commonly presumed. The FTP yields coherent bounds on probabilities of interest when available information is insufficient to determine a complete distribution. Further assertions that are natural to the problem motivate a partial ordering of conditional probabilities, extending the computation …

Multiscale Granger causality

2017

In the study of complex physical and biological systems represented by multivariate stochastic processes, an issue of great relevance is the description of the system dynamics spanning multiple temporal scales. While methods to assess the dynamic complexity of individual processes at different time scales are well-established, multiscale analysis of directed interactions has never been formalized theoretically, and empirical evaluations are complicated by practical issues such as filtering and downsampling. Here we extend the very popular measure of Granger causality (GC), a prominent tool for assessing directed lagged interactions between joint processes, to quantify information transfer a…

Bayesian models for data missing not at random in health examination surveys

2018

In epidemiological surveys, data missing not at random (MNAR) due to survey nonresponse may potentially lead to a bias in the risk factor estimates. We propose an approach based on Bayesian data augmentation and survival modelling to reduce the nonresponse bias. The approach requires additional information based on follow-up data. We present a case study of smoking prevalence using FINRISK data collected between 1972 and 2007 with a follow-up to the end of 2012 and compare it to other commonly applied missing at random (MAR) imputation approaches. A simulation experiment is carried out to study the validity of the approaches. Our approach appears to reduce the nonresponse bias substantially…