Search results for " Applications"

Immunomodulatory role of statins in autoimmune disease: is there a role for human gamma delta T cells ?

2006

Immunomodulatory role of statins in autoimmune disease: is there a role for human γδT cells?

p62: Friend or Foe? Evidences for OncoJanus and NeuroJanus Roles

2020

p62 is a versatile protein involved in the delicate balance between cell death and survival, which is fundamental for cell fate decision in the context of both cancer and neurodegenerative diseases. As an autophagy adaptor, p62 recognizes polyubiquitin chains and interacts with LC3, thereby targeting the selected cargo to the autophagosome with consequent autophagic degradation. Beside this function, p62 behaves as an interactive hub in multiple signalling including those mediated by Nrf2, NF-κB, caspase-8, and mTORC1. The protein is thus crucial for the control of oxidative stress, inflammation and cell survival, apoptosis, and metabolic reprogramming, respectively. As a multifunctional pr…

Recent advances in copper-based solid heterogeneous catalysts for azide-alkyne cycloaddition reactions

2022

The copper(I)-catalyzed azide−alkyne cycloaddition (CuAAC) reaction is considered to be the most representative ligation process within the context of the “click chemistry” concept. This CuAAC reaction, which yields compounds containing a 1,2,3-triazole core, has become relevant in the construction of biologically complex systems, bioconjugation strategies, and supramolecular and material sciences. Although many CuAAC reactions are performed under homogenous conditions, heterogenous copper-based catalytic systems are gaining exponential interest, relying on the easy removal, recovery, and reusability of catalytically copper species. The present review covers the most recently developed copp…

PREPARATION OF MACROMOLECULAR MATERIALS FOR BIOMEDICAL APPLICATIONS

2012

Properties and roles of BKCa channels in cultured cerebellar granule neuron: Experimental and simulation studies

2006

We studied the properties and roles of large-conductance calcium-sensitive potassium channels (BK"C"a) in cultured rat cerebellar granule neurons. In intact cells these channels had chord conductances of 130-200pS. The conductance, threshold for channel activation and the mean open time and open probability depend on the age of cells. In computer simulations the elimination of BK"C"a channel decreases the maximum and minimum peak values of an action potential, causes reduced hyperpolarization and increases firing frequency. The observed alterations may be linked to the complexity of granule neuron excitability during maturation and provide new insight into modeling the developmental changes…

Adaptive discontinuous evolution Galerkin method for dry atmospheric flow

2014

We present a new adaptive genuinely multidimensional method within the framework of the discontinuous Galerkin method. The discontinuous evolution Galerkin (DEG) method couples a discontinuous Galerkin formulation with approximate evolution operators. The latter are constructed using the bicharacteristics of multidimensional hyperbolic systems, such that all of the infinitely many directions of wave propagation are considered explicitly. In order to take into account multiscale phenomena that typically appear in atmospheric flows nonlinear fluxes are split into a linear part governing the acoustic and gravitational waves and a nonlinear part that models advection. Time integration is realiz…

Predictions forNDK,K̄DNandNDD̄molecules

2012

In this work baryon systems made of three hadrons which contain one nucleon and one D meson, and in addition another meson, , K or , are investigated using the Fixed Center Approximation to the Faddeev equations. In this work we use Λc(2595), X(3700) and D*s0(2317) bound states as a cluster and a third particle scattering form that clusters. In all cases we find bound states and quasibound states.

Robust Transmission for Reconfigurable Intelligent Surface Aided Millimeter Wave Vehicular Communications With Statistical CSI

2022

The integration of reconfigurable intelligent surface (RIS) into millimeter wave (mmWave) vehicular communications offers the possibility to unleash the potential of future proliferating vehicular applications. However, the high-mobility-induced rapidly varying channel state information (CSI) has been making it challenging to obtain the accurate instantaneous CSI (I-CSI) and to cope with the incurable high signaling overhead. The situation may become worse when the RIS with a large number of passive reflecting elements is deployed. To overcome this challenge, we investigate in this paper a robust transmission scheme for the time-varying RIS-aided mmWave vehicular communications, in which, s…

A correction method for dynamic analysis of linear systems

2004

Abstract This paper proposes an analytical method to improve the accuracy of the dynamic response of classically damped linear systems, as given by a standard truncated modal analysis. Upon computing the first m undamped modes of a n-degree-of-freedom system, two sets of equations in the Rn nodal space are built, which are uncoupled and govern the contribution to the response of the m computed modes and the remaining (n−m) unknown modes, respectively. The first set is solved in the Rm modal space by using the m available modes; the second set is solved in a reduced R(n−m) nodal space, without computing additional modes. Specifically, it is shown that the particular solution of the second se…

Forecasting basketball players' performance using sparse functional data*

2019

Statistics and analytic methods are becoming increasingly important in basketball. In particular, predicting players’ performance using past observations is a considerable challenge. The purpose of this study is to forecast the future behavior of basketball players. The available data are sparse functional data, which are very common in sports. So far, however, no forecasting method designed for sparse functional data has been used in sports. A methodology based on two methods to handle sparse and irregular data, together with the analogous method and functional archetypoid analysis is proposed. Results in comparison with traditional methods show that our approach is competitive and additio…