Search results for " Atta"

Attachment representations of professionals − Influence on intervention and implications for clinical training and supervision

2015

Abstract This study focuses on the attachment background of facilitators carrying out STEEP intervention, which may be a possible source of effectiveness variation. The attachment status of 161 professionals was assessed before STEEP training. 18 were followed up to evaluate the programme’s effectiveness regarding mother infant attachment. In the larger sample ( n =161), 76% of trainees had insecure attachment representations. While attachment security had no impact on intervention efficacy, professionals with an unresolved attachment trauma were 4.4 times less effective than professionals with no unresolved attachment status. This study highlights the importance of including professional w…

Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage.

2011

BACKGROUND: Tight-junction (TJ) protein degradation is a decisive step in hypoxic blood-brain barrier (BBB) breakdown in stroke. In this study we elucidated the impact of acute cerebral ischemia on TJ protein arrangement and the role of the apoptotic effector protease caspase-3 in this context. METHODOLOGY/PRINCIPAL FINDINGS: We used an in vitro model of the neurovascular unit and the guinea pig whole brain preparation to analyze with immunohistochemical methods the BBB properties and neurovascular integrity. In both methodological approaches we observed rapid TJ protein disruptions after 30 min of oxygen and glucose deprivation or middle cerebral artery occlusion, which were accompanied by…

The emotional timeline of September 11, 2001.

2010

Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector

2008

An ideal gene therapy vector should enable persistent transgene expression without limitations of safety and reproducibility. Here we report the development of a non-viral episomal plasmid DNA (pDNA) vector that appears to fulfil these criteria. This pDNA vector combines a scaffold/matrix attachment region (S/MAR) with a human liver-specific promoter (alpha1-antitrypsin (AAT)) in such a way that long-term expression is enabled in murine liver following hydrodynamic injection. Long-term expression is demonstrated by monitoring the longitudinal luciferase expression profile for up to 6 months by means of in situ bioluminescent imaging. All relevant control pDNA constructs expressing luciferas…

La fabula togata

2020

La commedia di ambientazione romana: autori, forme, opere e stile The comedy of the Ancient Roman setting: authors, forms, works and style

The Influence of Place Attachment, Ad-Evoked Positive Affect, and Motivation on Intention to Visit: Imagination Proclivity as a Moderator

2019

Integrating the theoretical foundations of symbolic interactionism, parasocial interaction, direct affect transfer, push and pull motivational framework, and narrative transportation, this study investigates the determinants of tourists’ intention to visit a destination using Heidi, a famous literary and television series persona, as a stimulus. Place attachment, ad-evoked positive affect, and motivation were theorized as antecedents of intention to visit and imagination proclivity as a moderator. The model was tested using data collected from 410 prospective Spanish tourists. Results show motivation and place attachment as key determinants of intention to visit among individuals with high…

Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver.

2010

We have previously described the development of a scaffold/matrix attachment region (S/MAR) episomal vector system for in vivo application and demonstrated its utility to sustain transgene expression in the mouse liver for at least 6 months following a single administration. Subsequently, we observed that transgene expression is sustained for the lifetime of the animal. The level of expression, however, does drop appreciably over time. We hypothesised that by eliminating the bacterial components in our vectors, we could improve their performance since bacterial sequences have been shown to be responsible for the immunotoxicity of the vector and the silencing of its expression when applied i…

Data Mining Approach for Detection of DDoS Attacks Utilizing SSL/TLS Protocol

2015

Denial of Service attacks remain one of the most serious threats to the Internet nowadays. In this study, we propose an algorithm for detection of Denial of Service attacks that utilize SSL/TLS protocol. These protocols encrypt the data of network connections on the application layer which makes it impossible to detect attackers activity based on the analysis of packet payload. For this reason, we concentrate on statistics that can be extracted from packet headers. Based on these statistics, we build a model of normal user behavior by using several data mining algorithms. Once the model has been built, it is used to detect DoS attacks. The proposed framework is tested on the data obtained w…

Antecedentes y consecuencias del uso de live videos en el marketing de influencers

2023

Desde la existencia de los medios de comunicación masiva, esto es, prensa, radio, televisión e internet, existen líderes de opinión que influyen en la toma de decisiones de su audiencia. Con la adopción masiva de las plataformas de redes sociales, la ubicuidad que proporcionan los dispositivos móviles y los live videos, la barrera de información entre el líder de opinión y su audiencia se ha reducido significativamente (Carillo et al., 2017). Las empresas, al entender que el desplazamiento de la atención de los consumidores hacia lo digital es más permanente que transitorio, han destinado mayores recursos a la publicidad digital, particularmente, en el influencer marketing o marketing de in…

Approximation problems in linear and non-linear analysis

2023

En esta tesis estudiamos problemas relacionados con aplicaciones de varios tipos que alcanzan su norma u operadores que alcanzan su radio numérico. Tras un capítulo introductorio donde se comentan las notaciones, los principales conceptos, y un resumen histórico del estado del arte, hay 4 capítulos de contenido matemático donde se estudian diversos tipos de problemas. En el capítulo 2, se estudian clases de operadores entre espacios de Banach tales que cuando casi alcanzan su norma (respectivamente, su radio numérico) en un punto (respectivamente, un estado), necesariamente la alcanzan en un punto cercano (respectivamente, en un estado cercano). Se obtienen resultados positivos para dominio…