Search results for " BAC"
showing 10 items of 2829 documents
Theoretical and Empirical Description of Phases in the Proving Processes of Undergraduates
2018
International audience; In the presented study we adopt a process-oriented perspective on proving in order to gain further insights into relevant actions and typical obstacles in undergraduates' approaches to proving. The primary aim is to theoretically and empirically describe different phases, understood as bunches of intentionally closely related actions of proving. Therefore, we suggest a theoretical model of the proving process and confirm empirically that it can be used as an analytical tool for proving approaches. Based on this model, several proving processes have been analysed. In this paper we present first findings regarding the contribution of each phase to proof construction as…
Genome degeneration and adaptation in a nascent stage of symbiosis
2014
Symbiotic associations between animals and microbes are ubiquitous in nature, with an estimated 15% of all insect species harboring intracellular bacterial symbionts. Most bacterial symbionts share many genomic features including small genomes, nucleotide composition bias, high coding density, and a paucity of mobile DNA, consistent with long-term host association. In this study, we focus on the early stages of genome degeneration in a recently derived insect-bacterial mutualistic intracellular association. We present the complete genome sequence and annotation of Sitophilus oryzae primary endosymbiont (SOPE). We also present the finished genome sequence and annotation of strain HS, a close…
La prevención de la rabia y la sanidad municipal en Valencia (1894-1916)
1998
Se estudia la introducción de la vacunación antirrábica en Valencia tras su descubrimiento por Pasteur en 1885. La investigación se ha realizado a partir de documentación de archivo y de prensa médica de la época. Su aplicación se enmarca dentro de la «medicina de laboratorio», mayoritariamente seguida por los integrantes del Cuerpo Municipal de Sanidad del Ayuntamiento valenciano y que permitió una estrecha relación con los laboratorios españoles y extranjeros situados en ese momento a la cabeza de la investigación bacteriológica.
Activation of NF-kappaB and IL-8 by yersinia enterocolitica invasin protein is conferred by engagement of rac1 and MAP kinase cascades.
2003
International audience; Yersinia enterocolitica triggers activation of the nuclear factor (NF)-kappaB and production of the proinflammatory chemokine interleukin (IL)-8 in intestinal epithelial cells. This activation is due to adhesion of the bacteria via their outer membrane protein invasin to the host cells. Using Clostridium difficile toxins that specifically inactivate small GTPases, and transfection of inhibitory proteins of the Rho-GTPases, we demonstrate that Rac1, but not Cdc42 or Rho, is required for activation of NF-kappaB by invasin. Invasin activated the mitogen activated protein kinases (MAPK) p38 and c-Jun N-terminal protein kinase (JNK) but not extracellular signal regulated …
La place et l'influence de l'épistémologie bachelardienne
2009
The McKenzie method in assessing, classifying and treating non-specific low back pain in adults with special reference to the centralization phenomen…
2010
The genome sequence of Blochmannia floridanus: Comparative analysis of reduced genomes
2003
Bacterial symbioses are widespread among insects, probably being one of the key factors of their evolutionary success. We present the complete genome sequence of Blochmannia floridanus , the primary endosymbiont of carpenter ants. Although these ants feed on a complex diet, this symbiosis very likely has a nutritional basis: Blochmannia is able to supply nitrogen and sulfur compounds to the host while it takes advantage of the host metabolic machinery. Remarkably, these bacteria lack all known genes involved in replication initiation ( dna A, pri A, and rec A). The phylogenetic analysis of a set of conserved protein-coding genes shows that Bl. floridanus is phylogenetically related to Buch…
Vigilancia de la susceptibilidad antibiótica y caracterización genotípica de aislados de Neisseria gonorrhoeae en la Comunidad Valenciana: proyecto m…
2020
Se calcula que cada año se producen más de 376 millones de nuevas infecciones transmitidas por vía sexual (ITS), representando las mismas un grave problema de salud pública a nivel mundial. Su incidencia se ha visto incrementada de forma alarmante durante las últimas dos décadas, causando perjuicios en la salud de aquellas personas que las padecen. Esta tendencia ascendente, similar en todos los países de Europa, responde a varias causas, muchas de ellas sociales. La gonorrea constituye, tras la infección producida por Chlamydia trachomatis, la segunda ITS más prevalente a nivel global. Tan solo en el año 2016, la Organización Mundial de la Salud (OMS) estimó en 86 millones los nuevos conta…
Ciclo del carbono y modelización biogeoquímica de un lago somero hipertrófico: la Albufera de Valencia
2015
Los lagos someros son uno de los ecosistemas acuáticos más numerosos a nivel global y hacen posible el desarrollo de multitud de actividades de interés económico y recreativo. En las últimas décadas, gran parte de estos lagos se han visto sujetos a un proceso de eutrofización cultural que a menudo conlleva una transición desde un estado "claro" caracterizado por una alta transparencia del agua y gran abundancia de macrófitos, a un estado "turbio" caracterizado por una baja transparencia del agua, dominancia de fitoplancton y macrófitos sumergidos prácticamente ausentes. El cambio que experimentó la Albufera de Valencia al estado turbio a principios de los años 1970 como resultado de un inte…
Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin s…
1994
Cytotoxic necrotizing factor type 2 (CNF2) produced by Escherichia coli strains isolated from intestinal and extraintestinal infections is a dermonecrotic toxin of 110 kDa. We cloned the CNF2 gene from a large plasmid carried by an Escherichia coli strain isolated from a lamb with septicemia. Hydropathy analysis of the deduced amino acid sequence revealed a largely hydrophilic protein with two potential hydrophobic transmembrane domains. The N-terminal half of CNF2 showed striking homology (27% identity and 80% conserved residues) to the N-terminal portion of Pasteurella multocida toxin. Methylamine protection experiments and immunofluorescence studies suggested that CNF2 enters the cytosol…