Search results for " BLADDER"

showing 10 items of 396 documents

Segmental Ureterectomy Versus Radical Nephroureterectomy in Older Patients Treated for Upper Tract Urothelial Carcinoma

2022

Introduction: The world population is ageing and surgical procedures for older patients are associated with higher perioperative morbidity and mortality rates than in younger patients. Segmental ureterectomy (SU) has been proposed as an alternative to radical nephroureterectomy (RNU) for selected upper tract urothelial carcinomas (UTUC), to reduce post-operative morbidity, and preserve renal function. The aim of this study was to compare RNU and SU in terms of post-operative complications, functional outcomes, and overall survival (OS) in older patients treated for UTUC. Materials and methods: Data of patients aged 75 years or older and treated for UTUC were included. The primary outcome wa…

Carcinoma Transitional CellSurvivalUreteral NeoplasmsUrologyAged; Kidney sparing surgery; Postoperative complications; Renal function; Survival; Glomerular Filtration Rate; Humans; Nephrectomy; Nephroureterectomy; Postoperative Complications; Retrospective Studies; Carcinoma Transitional Cell; Ureter; Ureteral Neoplasms; Urinary Bladder NeoplasmsCarcinomaUreteral NeoplasmNephrectomyNephroureterectomyPostoperative complicationPostoperative complicationsOncologyUrinary Bladder NeoplasmsRetrospective StudieHumansTransitional CellUreterAged; Kidney sparing surgery; Postoperative complications; Renal function; SurvivalKidney sparing surgeryRetrospective StudiesAgedRenal functionGlomerular Filtration RateHuman
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Time to safely omit bladder cuff removal for low-risk upper tract urothelial carcinoma

2021

Carcinoma Transitional Cellmedicine.medical_specialtyUreteral Neoplasmsbusiness.industryUrologyUrologyNephrectomyText miningUrinary Bladder NeoplasmsUpper tractNephrologyCuffHumansMedicinebusinessUrothelial carcinomaMinerva Urology and Nephrology
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Cellular basis of detrusor smooth muscle contraction

2015

Cellular basismedicine.medical_specialtybusiness.industryUrologyUrinary Bladder030232 urology & nephrologyMuscle SmoothSmooth muscle contractionAnatomySurgery03 medical and health sciences0302 clinical medicine030220 oncology & carcinogenesismedicineHumansCalcium SignalingbusinessMuscle ContractionSignal TransductionBJU International
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Therapeutic Modulation of Urinary Bladder Function: Multiple Targets at Multiple Levels

2015

Storage dysfunction of the urinary bladder, specifically overactive bladder syndrome, is a condition that occurs frequently in the general population. Historically, pathophysiological and treatment concepts related to overactive bladder have focused on smooth muscle cells. Although these are the central effector, numerous anatomic structures are involved in their regulation, including the urothelium, afferent and efferent nerves, and the central nervous system. Each of these structures involves receptors for—and the urothelium itself also releases—many mediators. Moreover, hypoperfusion, hypertrophy, and fibrosis can affect bladder function. Established treatments such as muscarinic antago…

Central Nervous Systemmedicine.medical_specialtyUrinary BladderPopulationCentral nervous systemMuscarinic Antagonistsurologic and male genital diseasesToxicologyBioinformaticsMuscle hypertrophyNeurons EfferentFibrosisInternal medicinemedicineAnimalsHumansNeurons AfferentUrotheliumeducationPharmacologyeducation.field_of_studyUrinary bladderbusiness.industryUrinary Bladder DiseasesMuscle SmoothAdrenergic beta-AgonistsHyperplasiamedicine.diseasefemale genital diseases and pregnancy complicationsUrodynamicsTreatment OutcomeEndocrinologymedicine.anatomical_structureOveractive bladderAdrenergic alpha-1 Receptor AntagonistsUrological AgentsUrotheliumbusinessSignal TransductionAnnual Review of Pharmacology and Toxicology
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A 1-year maintenance after early adjuvant intravesical chemotherapy has a limited efficacy in preventing recurrence of intermediate risk non-muscle-i…

2010

Study Type – Therapy (RCT) Level of Evidence 1b OBJECTIVE To evaluate the efficacy of 1-year maintenance after a 6-week cycle of early intravesical chemotherapy, as the role of maintenance in intravesical chemotherapy is debated. PATIENTS AND METHODS Between May 2002 and August 2003, 577 patients with non-muscle-invasive bladder cancer (NMI-BC) underwent transurethral resection (TUR) and early intravesical chemotherapy (epirubicin, 80 mg/50 mL). They were randomized between a 6-week induction cycle and the induction cycle plus maintenance with 10 monthly instillations. In all, 95 patients with T1G3, Tis or single and primary Ta–T1 G1–G2 tumours were excluded; 482 patients at intermediate ri…

Chemotherapymedicine.medical_specialtyBladder cancerUrinary bladdermedicine.diagnostic_testbusiness.industryUrologymedicine.medical_treatmentCancerCystoscopymedicine.diseaseSurgerylaw.inventionRegimenmedicine.anatomical_structureRandomized controlled triallawmedicinebusinessEpirubicinmedicine.drugBJU International
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Prognostic Significance of Histopathological Grading and Immunoreactivity for p53 and p21/WAF1 in Grade 2 pTa Transitional Cell Carcinoma of …

2001

At present, there are no predictors of tumour behaviour for grade (G) 2 pTa transitional cell carcinomas (TCC) of the bladder. Here we analyse the prognostic relevance of histopathological grading and the immunohistochemical detection of p53 and p21/WAF1.70 patients were newly diagnosed with G2 pTa TCC of the bladder based on transurethral resection specimens. Two pathologists, blinded with respect to the clinical outcome, confirmed the initial grade and subclassified the G2 lesions into G2a and G2b carcinomas based on the degree of nuclear atypia and the number of mitoses. Immunoreactivity for p53 and p21/WAF1 was evaluated semiquantitatively.There were 52 G2a and 18 G2b tumours, mean foll…

Cyclin-Dependent Kinase Inhibitor p21Pathologymedicine.medical_specialtyUrologyHistopathological gradingurologic and male genital diseasesCyclinsotorhinolaryngologic diseasesHumansMedicineGrading (tumors)Neoplasm StagingCarcinoma Transitional CellUrinary bladderbusiness.industryPrognosismedicine.diseasefemale genital diseases and pregnancy complicationsP21 waf1medicine.anatomical_structureTransitional cell carcinomaUrinary Bladder NeoplasmsTransitional CellImmunohistochemistryNeoplasm stagingTumor Suppressor Protein p53businessEuropean Urology
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Prognostic Value of p53, p21/WAF1, Bcl-2, Bax, Bak and Ki-67 Immunoreactivity in pT1 G3 Urothelial Bladder Carcinomas

2001

pT1 G3 bladder carcinomas are heterogeneous with respect to tumor recurrence and progression. Whereas some urologists treat these carcinomas by repeated transurethral resections often followed by intravesical chemotherapy or BCG instillation, others recommend cystectomy after tumor recurrence or early cystectomy after the initial diagnosis. Our goal was to determine the prognostic value of p53, p21/WAF1, Bcl-2, Bax, Bak, and Ki-67 immunoreactivity in these tumors. There were 30 patients with a new histopathological diagnosis of pT1 G3 urothelial carcinoma based on a transurethral resection specimen. Representative sections of these specimens were examined for the above markers. All patients…

Cyclin-Dependent Kinase Inhibitor p21medicine.medical_specialtyPathologyTime FactorsTumor suppressor genemedicine.medical_treatmentBcl 2 baxUrologyDisease-Free SurvivalCystectomyPredictive Value of TestsCyclinsProto-Oncogene ProteinsBiomarkers TumormedicineHumansNeoplasm InvasivenessRetrospective Studiesbcl-2-Associated X ProteinCarcinoma Transitional CellUrinary bladderBladder cancerbiologyMembrane ProteinsGeneral MedicinePrognosismedicine.diseaseImmunohistochemistrySurvival RateKi-67 Antigenbcl-2 Homologous Antagonist-Killer Proteinmedicine.anatomical_structureTransitional cell carcinomaProto-Oncogene Proteins c-bcl-2Urinary Bladder NeoplasmsTumor progressionKi-67biology.proteinTumor Suppressor Protein p53Follow-Up StudiesTumor Biology
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Surgery Illustrated - Surgical Atlas

2010

CystectomyMedical illustrationmedicine.medical_specialtymedicine.anatomical_structureUrinary bladderAtlas (anatomy)business.industryUrologyGeneral surgerymedicine.medical_treatmentmedicinebusinessBJU International
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Function And Morphology Of The Urinary Bladder After Denervation

2021

Öz bulunamadı.

Denervationmedicine.medical_specialtyContraction (grammar)Urinary bladderMorphology (linguistics)Physiologybusiness.industryUrinary BladderUrologyDenervationMuscle hypertrophymedicine.anatomical_structurePhysiology (medical)medicinebusiness
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Mechanical and electrophysiological effects of cromakalim on the human urinary bladder.

1994

The effects of cromakalim on spontaneous and induced mechanical activity of human detrusor muscle were investigated in vitro. Cromakalim produces a concentration-related decrease of spontaneous as well as carbachol- and K(+)-evoked contractions. This is the first study to utilize the patch clamp technique to elucidate the mechanism of action of cromakalim on human detrusor cells. Cromakalim hyperpolarizes the detrusor cells by increasing the net outward current which is most likely carried by potassium ions. In the human urinary bladder, this effect is mediated by a glibenclamide-sensitive potassium channel, as glibenclamide is able to diminish the relaxant effect of cromakalim and to preve…

Detrusor muscleAdultMalemedicine.medical_specialtyCromakalimCarbacholPatch-Clamp TechniquesPotassium Channelsmedicine.drug_classUrologyGuinea PigsUrinary BladderIn Vitro Techniquesurologic and male genital diseasesMembrane Potentialschemistry.chemical_compoundInternal medicineMedicineAnimalsHumansBenzopyransPyrrolesPatch clampUrinary bladderbusiness.industryParasympatholyticsMuscle relaxantMuscle SmoothHyperpolarization (biology)Middle Agedmusculoskeletal systemfemale genital diseases and pregnancy complicationsPotassium channelRatsElectrophysiologyEndocrinologymedicine.anatomical_structurechemistrycardiovascular systemFemaleStress MechanicalbusinessCromakalimmedicine.drugMuscle ContractionInvestigative urology (Berlin, Germany)
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