Search results for " BURDEN"
showing 10 items of 325 documents
Issues Affecting Quality of Life and Disease Burden in Lipoprotein Lipase Deficiency (Lpld) - First Step Towards a Pro Measure in Lpld
2015
Objectives: LPLD is an ultra-orphan genetic lipid disorder (prevalence 1-2/million). It is associated with severe hypertriglyceridemia and an increased risk of acute pancreatitis. Other manifestations include eruptive xanthoma, fatigue, difficulty with concentrating and cardiopulmonary symptoms. Associated symptoms, complications and the fat-restricted diet affect Quality of Life (QOL). Currently no disease-specific measure exists to assess QOL and the burden of LPLD. As part of post approval commitments of alipogene tiparvovec, regulatory bodies requested the development of a reliable measure of QOL in LPLD. This study evaluates existing EORTC questionnaires QLQ-C30 and QLQ-PAN26, and a ne…
Qualità della vita e carico assistenziale dei caregiver di pazienti affetti da demenza
2011
Obiettivo: In questo lavoro intendiamo valutare la qualità della vita e il grado di distress dei caregiver di pazienti affetti da demenza afferenti presso il Centro di Riferimento Regionale Demenze Senili-Alzheimer - Unità Valutativa Alzheimer, dell’A.S.P. di Palermo. Metodi: L’assessment si compone di una batteria testo-logica che comprende i seguenti tests: Relative Stress Scale, Caregivere Burden Inventory, Neuropsychiaric Inventory, Short Form-36 Healty Survey. Risultati: Dall’analisi dei dati emerge che il grado di stress del caregiver risulta proporzionale al numero di anni di accudimento del paziente. Inoltre i caregiver di sesso femminile dedicano un numero sensibilmente maggiore di…
Mapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000-2018
2021
Exclusive breastfeeding (EBF)—giving infants only breast-milk for the first 6 months of life—is a component of optimal breastfeeding practices effective in preventing child morbidity and mortality. EBF practices are known to vary by population and comparable subnational estimates of prevalence and progress across low- and middle-income countries (LMICs) are required for planning policy and interventions. Here we present a geospatial analysis of EBF prevalence estimates from 2000 to 2018 across 94 LMICs mapped to policy-relevant administrative units (for example, districts), quantify subnational inequalities and their changes over time, and estimate probabilities of meeting the World Health …
Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17
2020
Background: Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended home fluids (RHF) exist as alternative forms of ORT; however, it is unclear whether RHF prevent child mortality. Previous studies have shown considerable variation between countries in ORS and RHF use, but subnational variation is unknown. This study aims to produce high-resolution geospatial estimates of relative and absolute coverage o…
Global, regional, and national burden of diseases and injuries for adults 70 years and older:systematic analysis for the Global Burden of Disease 201…
2022
AbstractObjectivesTo use data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) to estimate mortality and disability trends for the population aged ≥70 and evaluate patterns in causes of death, disability, and risk factors.DesignSystematic analysis.SettingParticipants were aged ≥70 from 204 countries and territories, 1990-2019.Main outcomes measuresYears of life lost, years lived with disability, disability adjusted life years, life expectancy at age 70 (LE-70), healthy life expectancy at age 70 (HALE-70), proportion of years in ill health at age 70 (PYIH-70), risk factors, and data coverage index were estimated based on standardised GBD methods.ResultsGlo…
Single Point Incremental Forming: analysis of sustainability of the process through an experimental approach
2013
In literature, manufacturing processes have been studied with different approaches, but a lack of knowledge on the analysis of the energy required is still present. The aim of this paper is to carry out energy analysis on Single Point Incremental Forming process. Accordingly, a wide experimental investigation was executed by taking into account different process parameters (i.e. tool depth step, punch velocity and product shape). The total energy consumption was monitored during all the experiments and properly weighted with respect to the deformation energy, required to execute the process. A sensitivity analysis was also carried out to highlight the conditions which allow to save energy r…
The care of the informal caregiver's burden by the Spanish public system of social welfare: a review.
2010
Abstract This work analyzes the public social services system developed in Spain to attend dependent persons and their informal caregivers, examining in a more detailed way the current capacity of the Spanish public In-Home Help Service (HHS) to meet the demands of dependent elderly persons and its impact on their informal caregiver's burden. We begin with a brief introduction of the services by the Spanish public social services system developed to attend dependency; next, the evolution of the Spanish public HHS is described in a thorough way to identify the pros and cons of this service regarding the informal caregivers’ burden of dependent elders. Finally, recommendations are proposed to…
Travisamenti pretori in tema di esonero dalla responsabilità contrattuale tra causalità e vicinanza della prova
2020
La nota censura la pronuncia in commento a causa della scelta di addossare la prova della causalità materiale al creditore anche nell'ambito delle obbligazioni di facere non professionale, con ciò facendo segnare la piena equiparazione sul piano della causalità della responsabilità contrattuale alla responsabilità aquiliana. The note censures the judgment in question due to the choice of placing proof of material causation on the creditor also in the context of the obligations of non-professional facere, thereby marking the full equation in terms of causality of contractual liability with aquilian liability.
Durata e prescrizione nella garanzia per i i vizi della vendita
2020
Il saggio analizza due recenti sentenze della Corte di cassazione in tema di onere della prova e di decorso del termine di prescrizione in materia di azioni edilizie nella vendita. L'analisi tenta di dimostrare che la soluzione di entrambe le questioni dipende dall'esatta qualificazione giuridica del vincolo del venditore come garanzia, intesa come attribuzione di utilità senza cooperazione. Su queste basi è possibile pervenire a conclusioni diverse e più solide rispetto a quelle cui perviene la Corte di cassazione. The essay analyzes two recent judgments of the Court of Cassation regarding the burden of proof and the expiry of the limitation period for the claim in the field of actions aga…
BREVI NOTE SULL'ONERE DELLA PROVA NEL PROCESSO TRIBUTARIO
2019
La regola dell’onere della prova costituisce un pilastro fondamentale in ogni disciplina processuale. Essa si sviluppa in una molteplicita' di principi attraverso i quali il processo persegue la sua funzione, la ricerca della verita'. Nel processo tributario l’applicazione della regola dell’onere della prova non sempre appare ispirata al principio del giusto processo ed al contribuente a volte è richiesto di offrire una prova che va oltre le sue possibilita'.