Search results for " Bases"
showing 10 items of 272 documents
The roles for a Lewis base and MgCl2 in third-generation Ziegler-Natta catalysts
1998
Activity of a titanium catalyst supported on a bimetallic magnesium-aluminium system, involving a Lewis base [MgCl2(THF) 2 /Al(C 2 H 5 ) 2 Cl], was studied in ethylene polymerization, and the effect of the catalyst composition on the properties of the final polymer produced was investigated. Analysis and discussion of the findings covering also some part of the kinetic study, resulted in defining the roles for MgCl 2 and a Lewis base in the third-generation Ziegler-Natta catalysts. MgCl 2 forms a bimetallic complex with an organoaluminium compound, which involves also a Lewis base. Its reaction with TiCl 4 yields a very active catalyst wherein the Mg: Ti molar ratio is close to 1. This mean…
Formal and Informal Interpersonal Power in Organisations: Testing a Bifactorial Model of Power in Role-sets
2003
Cet article porte sur la structure et les proprietes des bases du pouvoir dans les situations organisationnelles. On y presente et y teste une theorie bifactorielle du pouvoir elaboree a partir des sources du pouvoir identifiees par French & Raven. Cette theorie pose: a) le pouvoir formel englobe la legitimite et la possibilite d’imposer et de recompenser, le pouvoir informel l’arbitrage et l’expertise, b) le pouvoir formel est liea la hierarchie, c) il est asymetrique alors que le pouvoir informel est reciproque, d) et en relation negative avec le conflit. Un echantillon de 155 sujets a decrit ses relations de pouvoir et ses conflits avec les 1093 membres de son milieu professionnel, super…
In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration
2019
The availability of in vitro tools that are constructed on the basis of a detailed knowledge of key aspects of gastrointestinal (GI) physiology and their impact on formulation performance and subsequent drug release behaviour is fundamental to the success and efficiency of oral drug product development. Over the last six years, the development and optimization of improved, biorelevant in vitro tools has been a cornerstone of the IMI OrBiTo (Oral Biopharmaceutics Tools) project. By bringing together key industry and academic partners, and by linking tool development and optimization to human studies to understand behaviour at the formulation/GI tract interface, the collaboration has enabled …
Targeting the mitochondrial pathway to induce apoptosis/necrosis through ROS by a newly developed Schiff’s base to overcome MDR in cancer
2011
Abstract Multidrug resistance (MDR) in cancer, a major obstacle to successful application of cancer chemotherapy, is often characterized by over-expression of multidrug resistance-related proteins such as MRP1, P-gp or elevated glutathione (GSH) level. Efflux of drugs by functional P-gp, MRP1 and elevated GSH level can confer resistance to apoptosis induced by a range of different stimuli. Therefore, it is necessary to develop new cell death inducers with relatively lower toxicity toward non-malignant cells that can overcome MDR by induction of apoptotic or non-apoptotic cell death pathways. Herein we report the synthesis and spectroscopic characterization of a GSH depleting, redox active S…
Toward completion of the Earth’s proteome: an update a decade later
2017
Protein databases are steadily growing driven by the spread of new more efficient sequencing techniques. This growth is dominated by an increase in redundancy (homologous proteins with various degrees of sequence similarity) and by the incapability to process and curate sequence entries as fast as they are created. To understand these trends and aid bioinformatic resources that might be compromised by the increasing size of the protein sequence databases, we have created a less-redundant protein data set. In parallel, we analyzed the evolution of protein sequence databases in terms of size and redundancy. While the SwissProt database has decelerated its growth mostly because of a focus on i…
The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species
2012
The amyloid β (Aβ) peptide, which is abundantly found in the brains of patients suffering from Alzheimer disease, is central in the pathogenesis of this disease. Therefore, to understand the processing of the amyloid precursor protein (APP) is of critical importance. Recently, we demonstrated that the metalloprotease meprin β cleaves APP and liberates soluble N-terminal APP (N-APP) fragments. In this work, we present evidence that meprin β can also process APP in a manner reminiscent of β-secretase. We identified cleavage sites of meprin β in the amyloid β sequence of the wild type and Swedish mutant of APP at positions p1 and p2, thereby generating Aβ variants starting at the first or seco…
Hamiltonians Generated by Parseval Frames
2021
AbstractIt is known that self-adjoint Hamiltonians with purely discrete eigenvalues can be written as (infinite) linear combination of mutually orthogonal projectors with eigenvalues as coefficients of the expansion. The projectors are defined by the eigenvectors of the Hamiltonians. In some recent papers, this expansion has been extended to the case in which these eigenvectors form a Riesz basis or, more recently, a ${\mathcal{D}}$ D -quasi basis (Bagarello and Bellomonte in J. Phys. A 50:145203, 2017, Bagarello et al. in J. Math. Phys. 59:033506, 2018), rather than an orthonormal basis. Here we discuss what can be done when these sets are replaced by Parseval frames. This interest is moti…
Non-self-adjoint hamiltonians defined by Riesz bases
2014
We discuss some features of non-self-adjoint Hamiltonians with real discrete simple spectrum under the assumption that the eigenvectors form a Riesz basis of Hilbert space. Among other things, {we give conditions under which these Hamiltonians} can be factorized in terms of generalized lowering and raising operators.
Bessel sequences, Riesz-like bases and operators in Triplets of Hilbert spaces
2016
Riesz-like bases for a triplet of Hilbert spaces are investigated, in connection with an analogous study for more general rigged Hilbert spaces performed in a previous paper. It is shown, in particular, that every \(\omega \)-independent, complete (total) Bessel sequence is a (strict) Riesz-like basis in a convenient triplet of Hilbert spaces. An application to non self-adjoint Schrodinger-type operators is considered. Moreover, some of the simplest operators we can define by them and their dual bases are studied.
On non-self-adjoint operators defined by Riesz bases in Hilbert and rigged Hilbert spaces
2018
In this paper we discuss some results on non self-adjoint Hamiltonians with real discrete simple spectrum under the assumption that their eigenvectors form Riesz bases of a certain Hilbert space. Also, we exhibit a generalization of those results to the case of rigged Hilbert spaces, and we also consider the problem of the factorization of the aforementioned Hamiltonians in terms of generalized lowering and raising operators.