Search results for " Bias"
showing 10 items of 437 documents
Exercise treatment effect modifiers in persistent low back pain: an individual participant data meta-analysis of 3514 participants from 27 randomised…
2020
BackgroundLow back pain is one of the leading causes of disability worldwide. Exercise therapy is widely recommended to treat persistent non-specific low back pain. While evidence suggests exercise is, on average, moderately effective, there remains uncertainty about which individuals might benefit the most from exercise.MethodsIn parallel with a Cochrane review update, we requested individual participant data (IPD) from high-quality randomised clinical trials of adults with our two primary outcomes of interest, pain and functional limitations, and calculated global recovery. We compiled a master data set including baseline participant characteristics, exercise and comparison characteristic…
Estimating the gravity equation with the actual number of exporting firms
2013
Para estimar correctamente el efecto de los costes de comerciar sobre las exportaciones de las empresas, la ecuación de gravedad debe controlar por el número de empresas que opera en el mercado internacional. Debido a la ausencia de datos, estudios anteriores han controlado esta variable mediante técnicas econométricas que también pueden generar estimaciones sesgadas. Para superar estos problemas este trabajo estima una ecuación de gravedad utilizando una nueva base de datos de la OCDE y EUROSTAT , que incluye el número de empresas exportadoras en cada relación bilateral. Nuestros resultados muestran que no controlar el margen extensivo genera sesgos muy importantes en la estimación de los …
Natural selection mediated by seasonal time constraints increases the alignment between evolvability and developmental plasticity
2021
Abstract Phenotypic plasticity can either hinder or promote adaptation to novel environments. Recent studies that have quantified alignments between plasticity, genetic variation, and divergence propose that such alignments may reflect constraints that bias future evolutionary trajectories. Here, we emphasize that such alignments may themselves be a result of natural selection and do not necessarily indicate constraints on adaptation. We estimated developmental plasticity and broad sense genetic covariance matrices (G) among damselfly populations situated along a latitudinal gradient in Europe. Damselflies were reared at photoperiod treatments that simulated the seasonal time constraints ex…
Disadvantaged neighborhoods and the spatial overlap of substantiated and unsubstantiated child maltreatment referrals
2019
Abstract Background Considerable debate exists on whether the substantiation decision is a reliable measure for rates of maltreatment. Studies have shown that risks among children victims of maltreatment versus children investigated but unsubstantiated are similar. Objective This paper aims to respond to two research questions: (1) Do most child maltreatment referrals, substantiated and unsubstantiated, come from the same neighborhoods? (2) Do substantiated and unsubstantiated referrals share the same neighborhood risk factors? Participants and settings We used geocoded data from substantiated (n = 1799) and unsubstantiated (n = 1638) child maltreatment referrals in Valencia, Spain (2004–20…
Effect of an upright (vs. stooped) posture on interpretation bias, imagery, and emotions
2020
[EN] Background and objectives: Adopting an upright (vs. stooped) posture has been related to positive effects on emotional and cognitive processes. However, there is no evidence concerning the effect of posture on two key processes associated with the maintenance of depression: interpretation bias and vividness of mental imagery. The objectives were to investigate the effect of adopting an upright (vs. stooped) posture on interpretation bias and vividness of positive and negative mental imagery, and to explore the interplay between these processes and depression-related emotions. Methods: The sample consisted of 54 participants (M-age = 22.00, 64.8% women), who were randomly assigned to th…
Abnormal emotional processing in maltreated children diagnosed of Complex Posttraumatic Stress Disorder.
2017
Abstract Maltreated children usually show a specific pattern of emotional and behavioral symptoms that exceed those relating to posttraumatic stress disorder (PTSD). These symptoms have been defined as Complex PTSD (CPTSD). The underlying attentional mechanisms of abnormal emotional processing and their relation to the clinical presentation of CPTSD are not well understood. A visual dot-probe paradigm involving pre-attentive (i.e., 500 ms) and attentive (i.e., 1500 ms) presentation rates of neutral versus emotional (i.e., angry, happy or sad) facial expressions was applied. Twenty-one maltreated CPTSD children were compared with twenty-six controls. The results are as follows: an attention …
Communication deficits and avoidance of angry faces in children with autism spectrum disorder.
2017
Abstract Background Understanding how emotional faces are processed is important to help characterize the social deficits in Autism Spectrum Disorder (ASD). Aims We examined: (i) whether attention is modulated by emotional facial expression; (ii) the time course of the attentional preferences (short vs. long stimulus presentation rates); and (iii) the association between attentional biases and autistic symptomatology. Method and procedures We applied a dot-probe experiment with emotional faces (happy, sad, and angry). The sample was composed of ASD children without additional language and/or intellectual impairments (n = 29) and age-matched Typically Developing (TD) children (n = 29). Outco…
Maternal medication use and the risk of brain tumors in the offspring: The SEARCH international case-control study
2006
International audience; N-nitroso compounds (NOC) have been associated with carcinogenesis in a wide range of species, including humans. There is strong experimental data showing that nitrosamides (R(1)NNO.COR(2)), a type of NOC, are potent neuro-carcinogens when administered transplacentally. Some medications are a concentrated source of amides or amines, which in the presence of nitrites under normal acidic conditions of the stomach can form NOC. Therefore, these compounds, when ingested by women during pregnancy, may be important risk factors for tumors of the central nervous system in the offspring. The aim of the present study was to test the association between maternal use of medicat…
Association of childhood leukaemia with factors related to the immune system
1999
The childhood peak of common acute lymphoblastic leukaemia has been proposed as being a rare response to delayed exposure to a common infection. In this context, factors related to the child’s immune system are of special interest. Information on such factors was obtained in a recent German case-control study comprising more than 1000 children with acute leukaemia. Neither being the first-born child, nor a short duration of breastfeeding, indicators of a deficit in viral contacts during infancy or the number of infectious diseases, were significant risk factors. We observed a strong association with fewer routine immunizations with a 3.2-fold increase for those children getting less than fo…
Elite athletes live longer than the general population: a meta-analysis
2014
OBJECTIVE: To perform a meta-analysis of cohort studies aimed at providing an accurate overview of mortality in elite athletes. PATIENTS AND METHODS: We reviewed English-language scientific articles available in Medline and Web of Science databases following the recommendations of the Meta-analyses Of Observational Studies in Epidemiology group. We searched for publications on longevity and professional or elite athletes (with no restriction on the starting date and up to March 31, 2014). RESULTS: Ten studies, including data from a total of 42,807 athletes (707 women), met all inclusion criteria. The all-cause pooled standard mortality ratio (SMR) was 0.67 (95% CI, 0.55-0.81; P<.001) with n…