Search results for " Biologia molecolare"
showing 10 items of 267 documents
Capitolo 1 (Una visione d'insieme delle cellule e delle metodologie sperimentali per il loro studio) de: LA CELLULA "Un approccio molecolare" II ediz…
2009
Molecular Network Establishing Dorsal-Ventral polarity during sea urchin embryogenesis
2015
Conservazione di legature erratiche dell'archivio storico diocesano di Palermo: monitoraggio ambientale e microbico
2010
Prime indicazioni sulle biocenosi associate alle mummie delle Catacombe dei Cappuccini di Palermo
2009
La fama del convento, costruito dai Cappuccini di Palermo nel 1533, è dovuta in gran parte alle famose "Catacombe". L’origine delle catacombe si fa risalire al 1599 circa, quando i frati, sfruttando una preesistente cavità naturale al di sotto dell’altare maggiore della chiesa, trasferirono le salme di 40 frati precedentemente sepolti presso il lato meridionale della chiesa stessa. I frati iniziarono ad ampliare le catacombe, scavando nel sottosuolo, in relazione al crescente numero di nuove salme che nel tempo si conservavano. Allo stato attuale le catacombe sono una sorta di cimitero sotterraneo, in uso nel XVII secolo, costituito da lunghe gallerie scavate nel tufo per un’estensione di c…
RNA mediated trans-activation: its therapeutic potential in anaplastic thyroid cancer
2014
RNA mediated trans-Activation is a proposed mechanism involved in the setting of the epigenetic state of chromatin. It has been studied first in Drosophila melanogaster where it seems that at least some transcribed loci are marked as transcriptionally active by their own transcripts. This effect acts in trans and in some cases could give rise to a transgenerational paramutational-like effect. This work studies RNA mediated trans-activation in the light of one of its possible applications, specifically its use as a therapeutic strategy for the incurable and highly aggressive ATC (anaplastic thyroid cancer). We explore the possibility to reactivate the Thyroid specific NIS (Natrium-Iodine sym…
Mitochondrial Proteomics: An Approach to Identify Cellular Stress Induced By Amyloid-Beta Peptide
2014
Mitochondria are dynamic ATP-generating organelle which contribute to many cellular functions including bioenergetic processes. intracellular calcium regulation, alteration of reduction-oxidation potential of cells, free radical scavenging, and activation of caspase-mediated celi death. Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Mitochondrial functions can be negatively affected by Amyloid Beta-peptide (ABeta), an important component in Alzheimer's disease (AD) pathogenesis, and ABeta can interact with mitochondria and cause mitochondrial dysfunction. One of the most accepted hypotheses for AD onset implicates that mito…
Role of hypoxia in pemetrexed-resistance of mesothelioma mediated by proton-coupled folate transporter, and preclinical activity of new anti-LDH comp…
2018
Introduction There are few effective therapies for malignant pleural mesothelioma (MPM), which remains one of the most lethal cancers. We previously demonstrated that low expression of the PCFT transporter, both at mRNA and protein levels, is associated with shorter survival of MPM patients treated with pemetrexed (Giovannetti et al., 2017). Since hypoxia has also been associated to antifolate-resistance (Raz et al, 2014), this study was aimed at elucidating key factors in pemetrexed resistance and hypoxia that may contribute to the rational development of novel therapeutic interventions against mesothelioma. Methods The levels of PCFT and of the hypoxia marker carbonic anhydrase-IX were de…
Preliminary genetic characterisation of Southern Smooth Snake Coronella girondica (Serpentes, Colubridae) populations in Italy, with some considerati…
2022
The Southern smooth snake, Coronella girondica, is a small-sized colubrid found in Northwest Africa and Southwest Europe. Mitochondrial DNA-based studies showed that the species can be split into five clades: two from Northwest Africa (one Moroccan and one Tunisian-Algerian) and three from Europe (one in the south-west of the Iberian Peninsula, one in the south-east of Spain and one in the rest of the European range). With regards to Italy, to date, only two samples have been analysed both from the Province of Pisa, Tuscany, pointing at that fact that genetic characterisation of Italian populations is still lacking. Accordingly, we have increased the sampling coverage with 19 new samples fr…
Effetto combinato di cadmio e sulfonammidici sullo sviluppo degli embrioni di riccio di mare: un'indagine molecolare
2013
SEA URCHIN RESEARCH: MILESTONES, MEMORIES, AND FUTURE CHALLENGES
2017
The sea urchin eggs and embryos have been used for nearly two centuries as experimental models for classical and modern developmental biology. In the late 1870s, the ground-breaking observations independently obtained by Hertwig and Fol highlighted for the first time that a single sperm enters the oocyte and the male and female pronuclei fuse at fertilization.1 From that point on, the seminal studies of Boveri, Driesch, and Herbst allowed conceptualization of basic biological themes, such as the chromosome theory of heredity.2 In the first half of the twentieth century, the embryo manipulation experiments performed by Hörstadius and Runnström further advanced the field, introducing the conc…