Search results for " Bran"
showing 10 items of 362 documents
Bioactive triterpenes of protium heptaphyllum gum resin extract display cholesterol-lowering potential
2021
Hypercholesterolemia is one of the major causes of cardiovascular disease, the risk of which is further increased if other forms of dyslipidemia occur. Current therapeutic strategies include changes in lifestyle coupled with drug administration. Statins represent the most common therapeutic approach, but they may be insufficient due to the onset of resistance mechanisms and side effects. Consequently, patients with mild hypercholesterolemia prefer the use of food supplements since these are perceived to be safer. Here, we investigate the phytochemical profile and cholesterol-lowering potential of Protium heptaphyllum gum resin extract (PHE). Chemical characterization via HPLC-APCI-HRMS2 and…
Mitigating anticipated effects of systematic errors supports sister-group relationship between Xenacoelomorpha and Ambulacraria.
2019
International audience; Xenoturbella and the acoelomorph worms (Xenacoelomorpha) are simple marine animals with controversial affinities. They have been placed as the sister group of all other bilaterian animals (Nephrozoa hypothesis), implying their simplicity is an ancient characteristic ]; alternatively, they have been linked to the complex Ambulacraria (echinoderms and hemichordates) in a clade called the Xenambulacraria , suggesting their simplicity evolved by reduction from a complex ancestor. The difficulty resolving this problem implies the phylogenetic signal supporting the correct solution is weak and affected by inadequate modeling, creating a misleading non-phylogenetic signal. …
Impact of reducing fat, salt and sugar in commercial foods on consumer acceptability and willingness to pay in real tasting conditions: A home experi…
2017
International audience; Decreasing obesity or cardiovascular disease can be achieved by eating healthier foods with reduced contents of fat, salt and sugar. However, these ingredients have a significant impact on the sensory quality of the food products that contain these ingredients, especially cooked sausage, chorizo, dry sausage, cheese and muffins. In this study, consumer appreciation of these five commercialized products (non reformulated versions) and their respective reformulated versions with reduced contents of salt, fat and sugar was tested. An original home experiment was performed to assess consumer appreciation in natural consumption conditions. The experiment was divided into …
Chronically elevated branched chain amino acid levels are pro-arrhythmic.
2022
Aim. Cardiac arrhythmias comprise a major health and economic burden and are associated with significant morbidity and mortality, including cardiac failure, stroke and sudden cardiac death (SCD). Development of efficient preventive and therapeutic strategies is hampered by incomplete knowledge of disease mechanisms and pathways. Our aim is to identify novel mechanisms underlying cardiac arrhythmia and SCD using an unbiased approach. Methods and Results. We employed a phenotype-driven N-ethyl-N-nitrosourea (ENU) mutagenesis screen and identified a mouse line with a high incidence of sudden death at young age (6-9 weeks) in the absence of prior symptoms. Affected mice were found to be homozyg…
Higher glucose availability augments the metabolic responses of the C2C12 myotubes to exercise-like electrical pulse stimulation
2021
The application of exercise-like electrical pulse simulation (EL-EPS) has become a widely used exercise mimetic in vitro. EL-EPS produces similar physiological responses as in vivo exercise, while less is known about the detailed metabolic effects. Routinely, the C2C12 myotubes are cultured in high-glucose medium (4.5 g/L), which may alter EL-EPS responses. In this study, we evaluate the metabolic effects of EL-EPS under the high- and low-glucose (1.0 g/L) conditions to understand how substrate availability affects the myotube response to EL-EPS. The C2C12 myotube, media, and cell-free media metabolites were analyzed using untargeted nuclear magnetic resonance (NMR)-based metabolomics. Furt…
Branch-and-price-and-cut for a service network design and hub location problem
2015
In the context of combined road-rail freight transport, we study the integrated tactical planning of hub locations and the design of a frequency service network. We consider a number of real-world constraints such as multiple transshipments of requests at hubs, transport time limits for requests, request splitting, and outsourcing possibilities. To our knowledge, the combination of problem features we deal with has not been described before. We present a path-based model and solve it with a branch-and-price-and-cut algorithm. Computational experiments show that large realistic instances from a major German rail freight company can be solved close to optimality within one hour on a standard …
Search for a Stable Six-Quark State at BABAR
2019
Recent investigations have suggested that the six-quark combination uuddss could be a deeply bound state (S) that has eluded detection so far, and a potential dark matter candidate. We report the first search for a stable, doubly strange six-quark state in Upsilon -> S anti-Lambda anti-Lambda decays based on a sample of 90 million Upsilon(2S) and 110 million Upsilon(3S) decays collected by the BABAR experiment. No signal is observed, and 90% confidence level limits on the combined Upsilon(2S,3S) -> S anti-Lambda anti-Lambda branching fraction in the range (1.2-1.4)x10^-7 are derived for m_S < 2.05 GeV. These bounds set stringent limits on the existence of such exotic particles.
A parametric description of the 3D structure of the Galactic bar/bulge using the VVV survey
2017
We study the structure of the inner Milky Way using the latest data release of the Vista Variables in Via Lactea (VVV) survey. The VVV is a deep near-infrared, multi-colour photometric survey with a coverage of 300 square degrees towards the Bulge/Bar. We use Red Clump (RC) stars to produce a high-resolution dust map of the VVV's field of view. From de-reddened colour-magnitude diagrams we select Red Giant Branch stars to investigate their 3D density distribution within the central 4 kpc. We demonstrate that our best-fit parametric model of the Bulge density provides a good description of the VVV data, with a median percentage residual of 5$\%$ over the fitted region. The strongest of the o…
A Hard X-Ray View of Scorpius X-1 with INTEGRAL : Nonthermal Emission?
2006
We present here simultaneous INTEGRAL/RXTE observations of Sco X-1, and in particular a study of the hard X-ray emission of the source and its correlation with the position in the Z-track of the X-ray color-color diagram. We find that the hard X-ray (above about 30 keV) emission of Sco X-1 is dominated by a power-law component with a photon index of ~3. The flux in the power-law component slightly decreases when the source moves in the color-color diagram in the sense of increasing inferred mass accretion rate from the horizontal branch to the normal branch/flaring branch vertex. It becomes not significantly detectable in the flaring branch, where its flux has decreased by about an order of…
P1319 Speckle tracking echocardiography in patients with acute coronary syndrome: the added value
2020
Abstract Background Speckle tracking echocardiography with assessment of left ventricular global longitudinal strain (GLS) allows to identify early signs of cardiac dysfunction. The superiority of GLS in the prediction of all-cause mortality in the general population compared with LVEF is well known; in addiction GLS improves risk stratification and recognize early left ventricular dysfunction in several clinical setting. Purpose the aim of this study was to assess the diagnostic and prognostic role of global and segmental strain in the early identification of cardiac dysfunction in patients with myocardial infarction without persistent ST segment elevation (NSTEMI) and without obvious wall…