Search results for " Brown"
showing 10 items of 136 documents
Cardiolipin synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis
2018
Summary Activation of energy expenditure in thermogenic fat is a promising strategy to improve metabolic health, yet the dynamic processes that evoke this response are poorly understood. Here we show that synthesis of the mitochondrial phospholipid cardiolipin is indispensable for stimulating and sustaining thermogenic fat function. Cardiolipin biosynthesis is robustly induced in brown and beige adipose upon cold exposure. Mimicking this response through overexpression of cardiolipin synthase (Crls1) enhances energy consumption in mouse and human adipocytes. Crls1 deficiency in thermogenic adipocytes diminishes inducible mitochondrial uncoupling and elicits a nuclear transcriptional respons…
Does iris(in) bring bad news or good news?
2017
Irisin, a novel myokine produced in response to physical activity, promotes white-to-brown fat transdifferentiation. The name irisin referred to the ancient Greek goddess Iris, the messenger who delivered (bad) news from the gods. In mice, it has been demonstrated that irisin plays a key role in metabolic regulation, energy expenditure and glucose homeostasis. New findings from various studies carried out in both animals and humans suggest that irisin might also have other favorable effects, such as increasing bone cortical mass, preventing hepatic lipid accumulation, and improving cognitive functions, thus mediating many exercise-induced health benefits. However, data on the role and funct…
A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function
2017
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3(+) regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4(+) T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction. Specifically, Ragulator-interacting protein C17o…
Materiality and atmosphere. Two American beat artists painting Europe
2019
The article discusses how European painting heavily influenced two American Beat painters in the post war years. Post-war American painting was often concerned with breaking away from traditional iconography and style, but Jay DeFeo and Joan Brown chose to engage with European traditional painting. Both artists travelled to Europe early in their careers and both declare an intense interest in European painters, paintings, and architecture. In Brown’s case particularly the works of Goya, Velazquez, and Rembrandt become scrutinized and remodeled in her pasty abstract style. De Feo, on her hand, states a particular interest in how the European cities’ distinct colors, lights and textures inspi…
Confirmatory factor analysis and psychometric properties of the Yale–Brown–Cornell Eating Disorders Scale Self-Report version (SR-YBC-EDS) in Spanish…
2015
[EN] Objective: The aimof the study was to adapt and validate the Yale Brown Cornell Eating Disorder Scale (YBC-EDS) transformed into a self-report format in Spanish clinical and non-clinical samples. Method: Eighty-three eating disordered patients and 358 non-clinical participants completed the Self Report-YBCEDS version (SR-YBC-EDS), the Eating Attitudes Test (EAT), and the Penn State Worry Questionnaire (PSWQ). Results: Confirmatory factor analyses of a two-factor second-order model showed adequate values of goodness-of fit indices for non-clinical (normed ÷2=13.4578; df=18; NFI=0.980; GFI=1.00; RMSEA= 0.00) and clinical samples (normed ÷2 = 26.5913; df =18; NFI = 0.944; GFI = 0.981; RMS…
Impact of trace metals from past mining on the aquatic ecosystem: a multi-proxy approach in the Morvan (France).
2014
10 pages; International audience; This study seeks to determine to what extent trace metals resulting from past mining activities are transferred to the aquatic ecosystem, and whether such trace metals still exert deleterious effects on biota. Concentrations of Cd, Cu, Pb and Zn were measured in streambed sediments, transplanted bryophytes and wild brown trout. This study was conducted at two scales: (i) the entire Morvan Regional Nature Park and (ii) three small watersheds selected for their degree of contamination, based on the presence or absence of past mining sites. The overall quality of streambed sediments was assessed using Sediment Quality Indices (SQIs). According to these standar…
Plan del nuevo Colegio Médico Browniano, que se establece en una Cofradía de ciegos : carta de don Neófilo Miranda a Don Hipólito Gutierrez dándole c…
Neófilo Miranda, seud. de Francisco Llansol. Palau, t.9, p. 371 Sign.: [A]-D4, E3
Mandibular brown tumor as the first manifestation of primary hyperparathyroidism: a case report
2013
EFFECT OF HOT AIR TREATMENT ON MINIMALLY PROCESSED CAULIFLOWER
2013
The request of minimally processed vegetable is continuously increasing, and there is a growing interest for new fresh cut products. Cauliflower, as other cabbages, is highly appreciated for its nutritional value due to the good content of vitamins, antioxidants and anti-carcinogenic compounds. It is suitable to be used as a minimally processed vegetable, but harvesting and the following processing can cause a severe stress determining the appearance of accelerated senescence symptoms. The aim of the present work was to investigate the effect of hot air treatment and cold storage on minimally processed green cauliflower. Fresh-cut cauliflower florets put in sealed PE bags were treated at 48…
Parameter Estimation for α-Fractional Bridges
2013
Let α, T > 0. We study the asymptotic properties of a least squares estimator for the parameter α of a fractional bridge defined as \(\mathrm{d}X_{t} = -\alpha \, \frac{X_{t}} {T-t}\,\mathrm{d}t + \mathrm{d}B_{t}\), 0 ≤ t \frac{1} {2}\). Depending on the value of α, we prove that we may have strong consistency or not as t → T. When we have consistency, we obtain the rate of this convergence as well. Also, we compare our results to the (known) case where B is replaced by a standard Brownian motion W.