Search results for " CALL"
showing 10 items of 222 documents
Predictability decomposition detects the impairment of brain-heart dynamical networks during sleep disorders and their recovery with treatment
2016
This work introduces a framework to study the network formed by the autonomic component of heart rate variability (cardiac process η ) and the amplitude of the different electroencephalographic waves (brain processes δ , θ , α , σ , β ) during sleep. The framework exploits multivariate linear models to decompose the predictability of any given target process into measures of self-, causal and interaction predictability reflecting respectively the information retained in the process and related to its physiological complexity, the information transferred from the other source processes, and the information modified during the transfer according to redundant or synergistic interaction betwee…
Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy
2013
Vici syndrome is a recessively inherited multisystem disorder characterized by callosal agenesis, cataracts, cardiomyopathy, combined immunodeficiency and hypopigmentation. To investigate the molecular basis of Vici syndrome, we carried out exome and Sanger sequence analysis in a cohort of 18 affected individuals. We identified recessive mutations in EPG5 (previously KIAA1632), indicating a causative role in Vici syndrome. EPG5 is the human homolog of the metazoan-specific autophagy gene epg-5, encoding a key autophagy regulator (ectopic P-granules autophagy protein 5) implicated in the formation of autolysosomes. Further studies showed a severe block in autophagosomal clearance in muscle a…
Benefits of a home-based physical exercise program in elderly subjects with type 2 diabetes mellitus
2011
Abstract Objective To analyze the effects of a home-based physical exercise program on quality of life, metabolic control, and anthropometric and biochemical parameters in people over 60 years of age with type 2 diabetes mellitus. Methods Eighty-four Spanish patients aged over 60 years were finally randomized to participate in a home-based, combined physical exercise program (aerobic and anaerobic exercises) or to receive conventional treatment for diabetes. At 6 months, effects on quality of life (EuroQoL questionnaire), HbA1c, fasting glucose, hypoglycemic events, weight, BMI, waist circumference, blood pressure, and biochemical parameters were assessed. Results Mean age of study particip…
CNS involvement in OFD1 syndrome: a clinical, molecular, and neuroimaging study
2014
Background Oral-facial-digital type 1 syndrome (OFD1; OMIM 311200) belongs to the expanding group of disorders ascribed to ciliary dysfunction. With the aim of contributing to the understanding of the role of primary cilia in the central nervous system (CNS), we performed a thorough characterization of CNS involvement observed in this disorder. Methods A cohort of 117 molecularly diagnosed OFD type I patients was screened for the presence of neurological symptoms and/or cognitive/behavioral abnormalities on the basis of the available information supplied by the collaborating clinicians. Seventy-one cases showing CNS involvement were further investigated through neuroimaging studies and neur…
Contralateral potentials in the suprasylvian gyrus evoked by pulvinar stimulation.
1974
AbstractIn encephale isole cats the transmission of the bioelectrical activity in the suprasylvian gyrus, evoked by contralateral pulvinar stimulation was explored. Through the excitability increase and decrease of the pulvinar (by strychnine or KCl, respectively), the surgical removal of the ipsilateral suprasylvian gyrus and the electrocoagulation of the posterior commissure it appeared that the transmission of the activity in the suprasylvian gyrus evoked by contralateral pulvinar stimulation occurs through both the callosal and the interthalamic pathway.
The role of the claustrum in the bilateral control of frontal oculomotor neurons in the cat.
1991
The effect of claustrum (CL) stimulation on the spontaneous unitary activity of ipsi and contralateral frontal oculomotor neurons, was studied in chloralose-anaesthetized cats. A total of 205 units was bilaterally recorded in the medial oculomotor area, homologous of the primate "frontal eye fields"; 127 neurons were identified as projecting to the superior colliculus; for 33 of these last units stimulation of the ipsilateral CL provoked an excitatory effect lasting 10-25 ms and appearing with a latency of 5-15 ms; on 8 units the excitatory effect was followed by an inhibition lasting 100-250 ms. Ninety-eight of the 127 neurons were also tested through activation of the contralateral CL: 13…
Satb2 Regulates Callosal Projection Neuron Identity in the Developing Cerebral Cortex
2008
SummarySatb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ gene. In mutant mice, β-galactosidase-labeled axons are absent from the corpus callosum and instead descend along the corticospinal tract. Satb2 mutant neurons acquire expression of Ctip2, a transcription factor that is necessary and sufficient for the extension of subcortical projections by cortical neurons. Conversely, ectopic expression of Satb2 in neural stem cells m…
Somatic embryogenesis and plant regeneration from pistil thin cell layers of Citrus
1999
Callus induction, somatic embryogenesis and plant regeneration were obtained in six different citrus species [Citrus deliciosa Ten. (cv 'Avana'), C.limon (L.) Burm. (cv 'Berna'), C.madurensis Lour. (cv 'CNR P9'), C.medica L. (cv 'Cedro di Trabia'), C.tardiva Hort. ex Tan. (cv 'CNR P6'), C.sinensis (L.) Osb. (cv 'Ugdulena 7')] from cultures of pistil transverse thin cell layer explants [(t)TCL]. Explants were cultured on three different media: the nutrients and vitamins of Murashige and Skoog medium alone (MS) or MS supplemented with either 500 mg l(-1) malt extract (MS I) or 500 mg l(-1) malt extract and 13.3 mu M 6-benzylaminopurine (MS II). Sucrose (146 mM) was used as the carbon source. …
Evidence for sex pheromones produced by males and females inBlatta orientalis (Dictyoptera, Blattidae).
1993
Males and females ofBlatta orientalis produce a volatile sex pheromone attractive at a distance. The male initiates courtship behavior by adopting a calling posture while emitting his sex pheromone. He exposes the anterior region of his tergites by stretching his abdomen horizontally. Morphological observations show the existence of male tergal glands on the anterior region of tergites 1 to 8. Behavioral assays of females utilizing methylene chloride extracts of various male body parts reveal that extracts of the anterior region of tergites are highly attractive and induce more positive responses that any other body part. Once near the male, the attracted female opens widely her genital atr…
The RFID technology for neurosciences: feasibility of limbs' monitoring in sleep diseases.
2009
This contribution investigates the feasibility of the passive UHF RF identification technology for the wireless monitoring of human body movements in some common sleep disorders by means of passive tags equipped with inertial switches. Electromagnetic and mechanical models as well as preliminary experimentations are introduced to analyze all the significant issues concerning the required power, the tag antenna design, the read distance, and the expected biosignals collected by the interrogation device.