Search results for " CARDIOVASCULAR DISEASE"

showing 10 items of 179 documents

Heat Shock Protein-60 and Risk for Cardiovascular Disease

2011

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. There is growing evidence that molecularchaperones, many of which are heat shock proteins HSPs, are involved in CVD pathogenesis. In this review we focus on HSP60,the human mitochondrial chaperone that also displays extramitochondrial and extracellular functions. HSP60 is typically cytoprotectivebut a number of stress conditions determine its conversion to a potentially toxic molecule for cells and tissues. We present illustrative examplesof specific subtypes of CVD where HSP60 is implicated in the initiation and/or progression of disease. The data not only indicatea pathogenic role for HSP60 but also its …

Riskanimal structuresChaperonin Heat shock protein-60 cardiomyocytes heart failure cardiovascular diseases atherosclerosisChaperonin heat shock protein 60 cardiomyocytes heart failure cardiovascular disease atherosclerosis apoptosis microRNAs (miRs) diabetes Atrial fibrillationApoptosischemical and pharmacologic phenomenaDiseaseBioinformaticsAutoimmune DiseasesPathogenesisHeat shock proteinAtrial FibrillationDrug DiscoveryExtracellularAnimalsHumansMyocytes CardiacHeart FailurePharmacologybiologyfungiChaperonin 60AtherosclerosisResponse to treatmentCardiovascular DiseasesReperfusion InjuryChaperone (protein)HypertensionImmunologybiology.proteinHSP60Stress conditionsBiomarkersCurrent Pharmaceutical Design
researchProduct

Cardiovascular Management Self-efficacy: Psychometric Properties of a New Scale and Its Usefulness in a Rehabilitation Context.

2015

Self-efficacy beliefs have been shown to affect various effective health-promoting behaviors in patients. Unfortunately, availability of reliable and valid measures of self-efficacy in cardiovascular diseases (CVDs) is still very limited. Background: Self-efficacy beliefs have been shown to affect various effective health-promoting behaviors in patients. Unfortunately, availability of reliable and valid measures of self-efficacy in cardiovascular diseases (CVDs) is still very limited. Purpose: The aims of this study were to present a new scale measuring self-efficacy beliefs in managing CVD and to examine its psychometric properties. Methods: The study involved 172 patients (mean age = 66.4…

Settore M-PSI/01 - Psicologia GeneraleAdultMalePsychometricsPsychometricsPersonality characteristicsmedicine.medical_treatmentAnxiety; Cardiovascular disease severity; Depression; Illness perception; Impairment in daily functioning; Medication adherence; Personality characteristics; Self-efficacy beliefs;Context (language use)Self-efficacy beliefsAnxietyAffect (psychology)Medication AdherencePersonality characteristicIllness perceptionmedicineCardiovascular disease severityHumansPsychological testingProspective StudiesGeneral PsychologyImpairment in daily functioningAgedSelf-efficacy beliefs; Cardiovascular disease severity; Impairment in daily functioning; Medication adherence; Personality characteristics; Anxiety; Depression; Illness perceptionSelf-efficacyAged 80 and overPsychological TestsRehabilitationCardiac RehabilitationDepressionSelf-efficacy beliefMiddle AgedSelf EfficacySelf-efficacy beliefs . Cardiovascular disease severity . Impairment in daily functioning . Medication adherence . Personality characteristics . Anxiety . Depression . Illness perceptionPsychiatry and Mental healthHealth psychologyCardiovascular DiseasesAnxietyFemalemedicine.symptomPsychologyClinical psychologyAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine
researchProduct

Predicting depression from illness severity in cardiovascular disease patients: self-efficacy beliefs, illness perception, and perceived social suppo…

2014

Background: Many studies have investigated the relationships between cardiovascular diseases and patients' depression; nevertheless, few is still known as regard the impact of illness severity on depression and whether psychosocial variables mediate this association. Purpose: The aim of this study is to investigate the putative mediating role of illness representations, self-efficacy beliefs, and perceived social support on the relationship between illness severity and depression. Methods: A total of 75 consecutive patients with cardiovascular disease (80 % men; mean age=65.44, SD=10.20) were enrolled in an Italian hospital. Illness severity was measured in terms of left ventricular ejectio…

Settore M-PSI/01 - Psicologia GeneraleAdultMalemedicine.medical_specialtymedia_common.quotation_subjectDiseaseSelf-efficacy beliefsSeverity of Illness IndexDepression Cardiovascular disease severity Self-efficacy beliefs Ilness perception Perceived social supportSocial supportVentricular Dysfunction LeftPerceived social supportRisk FactorsPerceptionSurveys and QuestionnairesSeverity of illnessmedicineIllness perceptionCardiovascular disease severityHumansDepression Cardiovascular disease severity Self-efficacy beliefs Illness perception Perceived social supportPsychiatryApplied PsychologyDepression (differential diagnoses)media_commonAgedSelf-efficacyAged 80 and overDepressionSocial SupportStroke VolumeMiddle AgedSelf EfficacyHealth psychologyCardiovascular DiseasesFemalePerceptionSelf ReportPsychologyPsychosocialClinical psychologyInternational journal of behavioral medicine
researchProduct

The influence of illness severity on health satisfaction in patients with cardiovascular disease: The mediating role of illness perception and self-e…

2015

The importance of psychological factors in improving conditions of cardiovascular disease (CVD) patients is stressed by the guidelines for their prevention and rehabilitation, but little is known about the impact of illness severity on patients well-being, and on the psychosocial variables that may mediate this association. The aim of this study was to investigate the role of illness perception and self-efficacy beliefs on the relationship between illness severity and health satisfaction in 75 CVD patients undergoing rehabilitation (80% men; mean age = 65.44) at the St. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy. Illness severity was measured in terms of left ventricular ejec…

Settore M-PSI/01 - Psicologia GeneraleAdultMalemedicine.medical_specialtyself-efficacy beliefsmedicine.medical_treatmentDiseasePersonal Satisfactionillness severity health satisfaction illness perception self-efficacy beliefs cardiovascular diseaseSeverity of Illness IndexIllness perceptionscardiovascular diseaseSeverity of illnessMedicineIllness severityHumansIn patientPsychiatryApplied PsychologyAgedSelf-efficacyAged 80 and overRehabilitationbusiness.industryMiddle AgedSelf EfficacyPsychiatry and Mental healthcardiovascular disease; health satisfaction; illness perception; illness severity; self-efficacy beliefsillness severityhealth satisfactionCardiovascular DiseasesPatient ComplianceFemaleillness perceptionbusinessPsychosocialAttitude to HealthClinical psychology
researchProduct

Relationship of Illness Severity with Health and Life Satisfaction in Patients with Cardiovascular Disease: The Mediating Role of Self-efficacy Belie…

2012

Guidelines for cardiovascular rehabilitation from different countries underline the importance of psychological factors in the achievement of improved clinical conditions and quality of life in patients with cardiovascular disease (CVD). Nevertheless, little research has been performed to identify the specific factors that greatly affect or foster patients' quality of life. The aim of the current study was to investigate the contribution of illness perceptions (IP) and self-efficacy beliefs (SE) on the impact exerted by illness severity on health and life satisfaction in patients with CVD undergoing a rehabilitation program. The study had a cross-sectional design and involved 116 patients (…

Settore M-PSI/01 - Psicologia GeneraleHealth satisfactionSelf-efficacyRehabilitationmedicine.medical_treatmentLife satisfaction Health satisfaction Cardiovascular disease severity Self-efficacy beliefs Illness perceptionsPsychological interventionLife satisfactionSelf-efficacy beliefsDiseaseLife satisfaction; Health satisfaction; Cardiovascular disease severity; Self-efficacy beliefs; Illness perceptionsAffect (psychology)Quality of life (healthcare)medicineCardiovascular disease severityLife satisfactionPositive psychologyIllness perceptionsPsychologySocial Sciences (miscellaneous)Clinical psychologyJournal of Happiness Studies
researchProduct

“Identification of molecular and genetic markers common to multifactorial diseases (cardiovascular diseases, metabolic disorders, tumors) associated …

Settore MED/05 - Patologia ClinicaGenetic markers molecular markers metabolic syndrome multifactorial diseases cardiovascular diseases metabolic disorders tumors.
researchProduct

Consensus On Women'S Health Aspects Of Polycystic Ovary Syndrome (Pcos)

2012

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females with a high prevalence. The etiology of this heterogeneous condition remains obscure and its phenotype expression varies. Two, widely cited, previous ESHRE/ASRM-sponsored PCOS consensus workshops focused on diagnosis (published in 2004) and infertility management (published in 2008). The present third PCOS consensus paper summarizes current knowledge and identifies knowledge gaps regarding various women's health aspects of PCOS. Relevant topics addressed-all dealt with in a systematic fashion-include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, preg…

Settore MED/09 - Medicina InternaConsensus Development Conferences as TopicmenopauseType 2 diabetesSettore MED/13 - EndocrinologiaQuality of lifecancer; cardiovascular disease; contraception; hirsutism; insulin resistance; menopause; PCOS; pregnancy; quality of life; type 2 diabetescardiovascular diseaseNeoplasmsinsulin resistancePCOShirsutismhirsutismReproductive BiologyPolycystic ovary syndrome (PCOS)RehabilitationObstetrics and GynecologyObstetrics & GynecologyMiddle AgedMenopausePhenotypecontraceptionCardiovascular DiseasesPCOS Cardiovascular risk adolescence cancer obesityFemalepregnancytype 2 diabetesPolycystic Ovary SyndromeAdultmedicine.medical_specialtyConsensusAdolescentDiabetes ComplicationsInsulin resistanceSDG 3 - Good Health and Well-beingmedicineHumanscancerMenstrual CycleAgedGynecologyPregnancybusiness.industryCancermedicine.diseaseSettore MED/40 - Ginecologia E OstetriciaReproductive MedicineDiabetes Mellitus Type 2quality of lifeWomen's Healthbusiness
researchProduct

Appropriateness criteria for the management of lipid-lowering therapy with alirocumab in high cardiovascular risk patients. The opinion of a multidis…

2020

High levels of LDL cholesterol (LDL-C) represent a causal factor for cardiovascular diseases on an atherosclerotic basis, with a direct correlation between these and mortality or cardiovascular events, such that the reduction of both is associated proportionally and linearly with the reduction of LDL-C.Statins and ezetimibe are used for LDL-C lowering but may not be sufficient to achieve the targets defined by the ESC/EAS guidelines, which recommend use of PCSK9 inhibitors for further LDL-C reduction in patients not at goal.This project submitted 86 clinical scenarios to a group of experts, cardiologists, internists and lipidologists, collecting their opinion on the appropriateness of diffe…

Settore MED/09 - Medicina InternaConsensusPCSK9 inhibitorFamilial hypercholesterolemiaHypercholesterolemiaAntibodies Monoclonal Humanized; Anticholesteremic Agents; Atherosclerosis; Cholesterol LDL; Consensus; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Italy; Risk Assessment; Risk Factors; Cardiovascular DiseasesConsensuAntibodies Monoclonal HumanizedRisk AssessmentAntibodiesLDLAcute coronary syndrome; Alirocumab; Cardiovascular risk; Familial hypercholesterolemia; PCSK9 inhibitors; Antibodies Monoclonal Humanized; Anticholesteremic Agents; Atherosclerosis; Cholesterol LDL; Consensus; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Italy; Risk Assessment; Risk Factors; Cardiovascular DiseasesRisk FactorsAnticholesteremic AgentMonoclonalHumansHumanizedAnticholesteremic AgentsCholesterol LDLCardiovascular riskAtherosclerosisCholesterolItalyPCSK9 inhibitorsCardiovascular DiseasesAtherosclerosiAcute coronary syndromeHydroxymethylglutaryl-CoA Reductase InhibitorsAlirocumab
researchProduct

New Frontiers in the Treatment of Homozygous Familial Hypercholesterolemia.

2021

: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder. The most common cause is a mutation in both alleles of the gene encoding for the low-density lipoprotein (LDL) receptor, although other causative mutations have been identified. Complications of atherosclerotic cardiovascular disease are common in these patients; therefore, reducing the elevated LDL-cholesterol burden is critical in their management. Conventionally, this is achieved by patients initiating lipid-lowering therapy, but this can present challenges in clinical practice. Fortunately, novel therapeutic strategies have enabled promising innovations in HoFH treatment. This review highlights recent and ongo…

Settore MED/09 - Medicina InternaGenetic enhancementHomozygous familial hypercholesterolemiaFamilial hypercholesterolemiaInclisiranBioinformaticsmedicine.disease_causeBenzimidazolePCSK9Hyperlipoproteinemia Type IIchemistry.chemical_compoundGene therapyAnticholesteremic AgentmedicineAngiopoietin-like 3HumansLow-density lipoprotein cholesterolAlleleAngiopoietin-like 3; Gene therapy; Gene-editing; Homozygous familial hypercholesterolemia; Inclisiran; Lomitapide; Low-density lipoprotein cholesterol; PCSK9MutationGene-editingAtherosclerotic cardiovascular diseasebusiness.industryPCSK9Anticholesteremic AgentsHomozygoteGenetic disorderGeneral MedicineCholesterol LDLmedicine.diseaseLomitapideLomitapidechemistrylipids (amino acids peptides and proteins)BenzimidazolesCardiology and Cardiovascular MedicinebusinessHumanHeart failure clinics
researchProduct

Similar prediction of the decreased total mortality, diabetes incidence or cardiovascular events using a relative- and an absolute-component Mediterr…

2013

Abstract Background and Aim: Accumulated evidence supports the effectiveness of Mediterranean-type diets (MeDiet) in reducing mortality and preventing several chronic diseases. Widely used scores to assess adherence to MeDiet are based on specific sample characteristics; alternatively, they might be built according to absolute/normative cut-off points for the consumption of specific food groups (pre-defined servings/day or/week). The aim of this study was to compare sample-specific MeDiet adherence scores (MDS) versus absolutenormative scores (Mediterranean Diet Adherence Screener e MEDAS) on their association with macronutrient intake, total mortality and incidence of chronic diseases. Des…

Settore MED/09 - Medicina InternaMediterranean diet Cardiovascular disease Diabetes Macronutrients
researchProduct