Search results for " CC"
showing 10 items of 188 documents
Human Memory Th17 Cell Populations Change Into Anti-inflammatory Cells With Regulatory Capacity Upon Exposure to Active Vitamin D
2019
Autoimmune diseases are characterized by an aberrantly activated immune system, resulting in tissue damage and functional disability in patients. An important therapeutic goal is to restore the deregulated immunological balance between pro- A nd anti-inflammatory T cells. This imbalance is illustrated by elevated levels and activity of memory Th17 cell populations, such as Th17, Th1/Th17, and Th17.1 cells, in various autoimmune diseases. These cells are characterized by the chemokine receptor CCR6, RORC expression and production of IL-17A, IFNγ, and TNFα. Using rheumatoid arthritis (RA) as a model of autoimmune disease, we here demonstrate that pro-inflammatory memory CCR6+ Th cells can swi…
Azithromycin Differentially Alters TCR-Activated Helper T Cell Subset Phenotype and Effector Function
2020
In addition to their antibiotic activities, azithromycin (AZM) exhibits anti-inflammatory effects in various respiratory diseases. One of the potent anti-inflammatory mechanisms is through inhibition of CD4+ helper T (Th) cell effector function. However, their impact on specific Th subset is obscure. Herein, we demonstrate the cellular basis of phenotypic and functional alterations associated with Th subsets following AZM treatment in vitro. Using well-characterized Th subset specific chemokine receptors, we report significant suppression of T cell receptor (TCR)-stimulated hyperactivated CCR4+CXCR3+ (Th0) expansion compared to CCR4-CXCR3+ (Th1-like) and CCR4+CXCR3- (Th2-like) cells. Intere…
Leukotriene B4-loaded microspheres: a new therapeutic strategy to modulate cell activation
2008
AbstractBackgroundLeukotriene B4(LTB4) is a potent inflammatory mediator that also stimulates the immune response. In addition, it promotes polymorphonuclear leukocyte phagocytosis, chemotaxis, chemokinesis and modulates cytokines release. Regarding chemical instability of the leukotriene molecule, in the present study we assessed the immunomodulatory activities conferred by LTB4released from microspheres (MS). A previous oil-in-water emulsion solvent extraction-evaporation method was chosen to prepare LTB4-loaded MS.ResultsIn the mice cremasteric microcirculation, intraescrotal injection of 0.1 ml of LTB4-loaded MS provoked significant increases in leukocyte rolling flux, adhesion and emig…
Co-evolution between streaming and live music leads a way to the sustainable growth of music industry : Lessons from the US experiences
2017
While digitization of music, particularly streaming services, has gained increasing popularity, it has also led to a steady decline in the revenues of recorded music industry. This is causing strong concern regarding a potential collapse of the music industry comparable to other print media industries such as newspaper and book publishing. However, recent changes in the music industry initiated by a resurgence of the live music industry are giving rise to some expectations for the survival and growth of the music industry. The parallel paths of increasing popularity of streaming services and a resurgence of live music suggest that these two dynamics are working together in a co-evolutionary…
Clinical indications for cardiac computed tomography. From the Working Group of the Cardiac Radiology Section of the Italian Society of Medical Radio…
2012
"\"La tomografia computerizzata del cuore (CCT) è diventata uno strumento efficace in differenti contesti clinici. Lo sviluppo della tecnologia ha portato ad una progressiva espansione delle indicazioni con una concomitante riduzione della dose di radiazioni necessaria per l’esecuzione dell’indagine. Ancora oggi sono pochi i documenti delle maggiori società scientifiche internazionali che si esprimono sulle effettive modalità di utilizzo e sulle indicazioni cliniche della CCT; in particolare mancano delle linee guida complete. Questo documento rispecchia la visione del gruppo di lavoro della Sezione di Cardio-Radiologia della Società Italiana di Radiologia Medica in merito alle indicazioni …
Ārpusšūnu cirkulējošo nukleīnskābju izpēte hipofīzes adenomas pacientos
2019
Līdz šim literatūrā nav ziņojumu par ccfDNA un cirkulējošo miRNS izpēti HA pacientu plazmā. Darbā tika novērtēta iespējamība detektēt HA izcelsmes ccfDNA plazmā, veicot mērķētu NGS pozīcijās, kuras saturēja HA somatiskās mutācijas, un veikts pētījums par miRNS sastāva izmaiņu detektēšanu plazmā 24 stundas pēc HA rezekcijas. HA eksomos atklātās somatiskās mutācijas tikai detektētas septiņās no 16 pārbaudītajām pozīcijām ccfDNA amplikonos. Divās ccfDNA pozīcijās mutantā alēle bija vairāk nekā 2% no kopējā nolasījumu skaita, kas varētu liecināt par šo ccfDNA izcelsmi no HA. Piecās pozīcijās no diviem HA pacientiem mutantās alēles īpatsvars ccfDNA bija ap 50%, kaut gan šīs mutācijas netika kons…
Calibration of the underground muon detector of the Pierre Auger Observatory
2021
To obtain direct measurements of the muon content of extensive air showers with energy above $10^{16.5}$ eV, the Pierre Auger Observatory is currently being equipped with an underground muon detector (UMD), consisting of 219 10 $\mathrm{m^2}$-modules, each segmented into 64 scintillators coupled to silicon photomultipliers (SiPMs). Direct access to the shower muon content allows for the study of both of the composition of primary cosmic rays and of high-energy hadronic interactions in the forward direction. As the muon density can vary between tens of muons per m$^2$ close to the intersection of the shower axis with the ground to much less than one per m$^2$ when far away, the necessary bro…
Search for sterile neutrinos in the CC verbatim_mark>mathend000# mode at the new CERN-SBLNF
2013
The possible existence of non-active neutrinos for the ElectroWeak interactions was first proposed in 1967 by B. Pontecorvo who named them "sterile" neutrinos. Recent tensions among world-wide experimental data renewed the possibility of one or more sterile neutrino states. Several "anomalies" emerged in radioactive sources and reactor neutrino experiments, as well as the long-standing LSND and the recent MiniBooNE hints for neutrino and antineutrino oscillations with a δm2 at the eV2 scale, not compatible with the standard 3 × 3 neutrino mixing scenario. While a huge effort is being devoted to establish the standard three-neutrino mixing paradigm no conclusive experiment was carried out to…
La banda municipal de valencia y su aportación a la historia de la música valenciana
2003
La Tesis analiza la trayectoria artística de la Banda Municipal de Valencia desde el año 1903 hasta finales del año 2002 y su aportación a la historia de la música valenciana. Primeramente, el autor hace un estudio sobre las agrupaciones de viento y percusión desde sus orígenes hasta la actualidad. Este análisis siempre ha sido enfocado desde el punto de vista de los grupos de músicos profesionales al servicio de los ayuntamientos, es decir, hacia las bandas o conjuntos municipales. Por ello, también hay un apartado dedicado a la formación de las primeras bandas municipales en la historia de España.En un segundo apartado se trata los diferentes aspectos sociales, musicales, culturales y pol…
Astrologia y hermetismo en Miguel Servet
1998
Miguel Serveto ha sido una de las figuras españolas más relevantes del Renacimiento. Por una parte, por su amplia cultura multidisciplinar propia de dicha época, además de su independencia de cualquier clero o sistema oficialmente establecido. Así llegó a ocupar un lugar de honor en una encrucijada clave para el desarrollo cultural europeo de la época. Su conocimiento de las lenguas clásicas propias del trilinguis homo: latín, griego y hebreo, le permitió leer obras clásicas que todavía no habían sido traducidas al latín. En su obra principal, Christianismi Restitutio, da muestras de una extraordinaria erudición, llegando a describir perfectamente la circulación menor de la sangre e intuyen…