Search results for " Cellular"
showing 10 items of 384 documents
Probabilistic Reversible Automata and Quantum Automata
2002
To study relationship between quantum finite automata and probabilistic finite automata, we introduce a notion of probabilistic reversible automata (PRA, or doubly stochastic automata). We find that there is a strong relationship between different possible models of PRA and corresponding models of quantum finite automata. We also propose a classification of reversible finite 1-way automata.
Improved constructions of quantum automata
2008
We present a simple construction of quantum automata which achieve an exponential advantage over classical finite automata. Our automata use \frac{4}{\epsilon} \log 2p + O(1) states to recognize a language that requires p states classically. The construction is both substantially simpler and achieves a better constant in the front of \log p than the previously known construction of Ambainis and Freivalds (quant-ph/9802062). Similarly to Ambainis and Freivalds, our construction is by a probabilistic argument. We consider the possibility to derandomize it and present some results in this direction.
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease
2017
Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors underlying memory defects in Alzheimer’s patients. In this regard, new evidence linking Alzheimer’s disease-related pathology and neuronal stem cells suggests that hippocampal neurogenesis impairment is an important factor underlying these cognitive deficits. However, because of conflicting results, the impact of Aβ pathology on neurogenesis/gliogenesis remains unclear. Here, we investigated the effect of Aβ on neuronal and glial proliferation by using an APP/PS1 transgenic m…
A novel model of human implantation: 3D endometrium-like culture system to study attachment of human trophoblast (Jar) cell spheroids.
2011
There is an urgent need to develop optimized experimental models to examine human implantation. These studies aimed to (i) establish a human endometrium-like three-dimensional (3D) culture system, and (ii) examine the attachment of trophoblast-like Jar spher- oids to the culture. In the present work, 3D endometrial cultures were constructed with fibrin-agarose as matrix scaffold, and using epithelial and stromal cells from both human primary cultures and established cell lines. An attachment assay between trophoblast cells and the 3D culture was developed. Epithelial cells (cytokeratin + ) concentrated on top of the matrix forming a monolayer, and stromal cells (vimentin + ) resided within …
Modulation of immune responses of Rhynchophorus ferrugineus (Insecta: Coleoptera) induced by the entomopathogenic nematode Steinernema carpocapsae (N…
2014
Aim of this study was to investigate relationships between the red palm weevil (RPW) Rhynchophorus ferrugineus (Olivier) and the entomopathogenic nematode Steinernema carpocapsae (EPN); particularly, the work was focused on the immune response of the insect host in naive larvae and after infection with the EPN. Two main immunological processes have been addressed: the activity and modulation of host prophenoloxidase-phenoloxidase (proPO) system, involved in melanization of not-self and hemocytes recognition processes responsible for not-self encapsulation. Moreover, immune depressive and immune evasive strategies of the parasite have been investigated. Our results suggest that RPW possess a…
Le linee cellulari V79 e Caco-2: due modelli per studi in vitro di epi-mutagenesi
2020
È da pochi anni noto che alcune sostanze, non classificabili come veri e propri mutageni, sono in realtà dei modulatori epigenetici ed inducono cambiamenti nella metilazione del DNA, nella acetilazione/deacetilazione degli istoni e possono modificare la sintesi endocellulare di alcuni miRNA. Inducendo modificazioni epigenetiche non causano mutazioni genetiche, sfuggono ai test di mutagenesi e carcinogenesi fino ad ora utilizzati ma possono ugualmente avere effetti fenotipici simili a quelli di un mutageno/carcinogeno. Per anni l’arsenico, noto veleno ad alte dosi, contaminante obbligato delle acque potabili, è stato oggetto di dibattiti sulla sua mutagenicità a basse dosi. Utilizzato, parad…
European consensus on grading bone marrow fibrosis and assessment of cellularity.
2005
Quantification of characteristic bone marrow biopsy features includes basic parameters such as cellularity and fiber content. These are important to assess the dynamics of disease processes with a significant impact on risk stratification, survival patterns and, especially, therapy-related changes. A panel of experienced European pathologists and a foreign expert evaluated, at a multi-headed microscope, a large number of representative slides of trephine biopsies from patients with myelofibrosis in an attempt to reach a consensus on how to grade cellularity and fibrosis. This included a critical evaluation of previously described scoring systems. During the microscopic analysis and subseque…
Superiority of exact quantum automata for promise problems
2011
In this note, we present an infinite family of promise problems which can be solved exactly by just tuning transition amplitudes of a two-state quantum finite automata operating in realtime mode, whereas the size of the corresponding classical automata grow without bound.
Implementing a Margolus Neighborhood Cellular Automata on a FPGA
2003
Margolus neighborhood is the easiest form of designing Cellular Automata Rules with features such as invertibility or particle conserving. In this paper we introduce a notation to describe completely a rule based on this neighborhood and implement it in two ways: The first corresponds to a classical RAM-based implementation, while the second, based on concurrent cells, is useful for smaller systems in which time is a critical parameter. This implementation has the feature that the evolution of all the cells in the design is performed in the same clock cycle.
Arsenic trioxide alters the differentiation of mouse embryonic stem cell into cardiomyocytes
2015
AbstractChronic arsenic exposure is associated with increased morbidity and mortality for cardiovascular diseases. Arsenic increases myocardial infarction mortality in young adulthood, suggesting that exposure during foetal life correlates with cardiac alterations emerging later. Here, we investigated the mechanisms of arsenic trioxide (ATO) cardiomyocytes disruption during their differentiation from mouse embryonic stem cells. Throughout 15 days of differentiation in the presence of ATO (0.1, 0.5, 1.0 μM) we analysed: the expression of i) marker genes of mesoderm (day 4), myofibrillogenic commitment (day 7) and post-natal-like cardiomyocytes (day 15); ii) sarcomeric proteins and their orga…