Search results for " Class A"

Cloning and characterization of Scavidin, a fusion protein for the targeted delivery of biotinylated molecules.

2001

We have constructed a novel fusion protein "Scavidin" consisting of the macrophage scavenger receptor class A and avidin. The Scavidin fusion protein is transported to plasma membranes where the avidin portion of the fusion protein binds biotin with high affinity and forms the basis for the targeted delivery of biotinylated molecules. Subcellular fractionation analysis, immunostaining, and electron microscopy demonstrated endosomal localization of the fusion protein. According to pulse-labeling and cross-linking studies Scavidin is found as monomers (55 kDa), dimers, and multimers, of which the 220-kDa form was the most abundant. The biotin binding capacity and active endocytosis of the bio…

Impact of Glutathione Peroxidase-1 Deficiency on Macrophage Foam Cell Formation and Proliferation: Implications for Atherogenesis

2013

Clinical and experimental evidence suggests a protective role for the antioxidant enzyme glutathione peroxidase-1 (GPx-1) in the atherogenic process. GPx-1 deficiency accelerates atherosclerosis and increases lesion cellularity in ApoE(-/-) mice. However, the distribution of GPx-1 within the atherosclerotic lesion as well as the mechanisms leading to increased macrophage numbers in lesions is still unknown. Accordingly, the aims of the present study were (1) to analyze which cells express GPx-1 within atherosclerotic lesions and (2) to determine whether a lack of GPx-1 affects macrophage foam cell formation and cellular proliferation. Both in situ-hybridization and immunohistochemistry of l…

The Importance of Positive Psychological Strengths in Well-Being and Adjustment of Romanian Emerging Adults: A Pattern and Variable-Oriented Approach

2021

Transition to adulthood in countries that have seen recent historical structural changes in society as well as changes in what it means to be an adult represents important contexts for investigations of ways in which positive development and transition to adulthood are experienced. Situated in such context, this cross-sectional study aimed to (1) describe profiles of positive psychological strengths, as measured by the Five Cs of positive youth development (PYD) and (2) document how identified profiles might differ in relation to other aspects of positive and problematic development. Participants were 272 Romanian emerging adults attending university (76% female; aged 19–29 years old, Mage …

Empirically-derived subgroups of Facebook users and their association with personality characteristics: a Latent Class Analysis

2018

Abstract In recent years, considerable research effort has been directed at the identification of relationships between psychological variables and Facebook usage indicators. However, the identification of homogeneous subgroups of individuals based on similar Facebook usage characteristics still presents a challenge. This study aims: (1) to empirically determine homogeneous groups of Facebook users based on variables regarding their personal experience on Facebook, by using a Latent Class Analysis; and (2) to examine the association between an individual's personality and interpersonal characteristics and the empirically-derived profiles of Facebook usage. Eight hundred and eleven Facebook …

FACEBOOK ADDICTION? UNO STUDIO SU STILI RELAZIONALI E CARATTERISTICHE DISFUNZIONALI IN SOGGETTI CON DIVERSE TIPOLOGIE DI UTILIZZO DEL SOCIAL NETWORK

Background: Previous studies on individual characteristics related to Facebook usage seems to support that active Facebook users are more likely to be higher in attachment anxiety or in extraversion, but specific interpersonal profiles of individual’s Facebook usage are still missing in the literature. The aims of the current study were: a) to investigate whether there is a specific interpersonal profile of Facebook users, and b) to explored the contribution of participants’ personality and interpersonal relationship characteristics on their profile group membership. Methods: We investigated a group of 811 subjects (aged from 17 to 61 years) with questionnaires measuring personality traits,…

Motives to practice exercise in old age and successful aging: A latent class analysis.

2018

Abstract Purpose The aim was to classify motives for exercising trying to find sets of related cases that share common motivations, and to relate these latent classes to markers of successful aging. Methods 725 old adult aged 55 to 97 years were sampled in several Spanish towns. Instruments: Successful Aging Inventory (SAI), International Physical Activity Questionnaire (IPAQ), Health Survey SF-8, Satisfaction with Life Scale (SWLS), and motives to practice exercise, were used. Latent Class Analyses (LCAs) were estimated. The classes obtained were compared on markers of successful aging. Results Three latent classes were deemed optimal. Significant differences for several markers of success…

The reasoned action approach applied to health behavior: Role of past behavior and tests of some key moderators using meta-analytic structural equati…

2018

Abstract Rationale The reasoned action approach (RAA) is a social cognitive model that outlines the determinants of intentional behavior. Primary and meta-analytic studies support RAA predictions for multiple health behaviors. However, including past behavior as a predictor in the RAA may attenuate model effects. Direct effects of past behavior on behavior may reflect non-conscious processes whereas indirect effects of past behavior through social cognitive variables may represent reasoned processes. Objective The present study extended a previous meta-analysis of the RAA by including effects of past behavior. The analysis also tested effects of candidate moderators of model predictions: be…

Modelling Unobserved Heterogeneity in Health and Health Care: an Extended Latent Class Approach

2011

Frailty Status Typologies in Spanish Older Population: Associations with Successful Aging

2020

Background: Defining frailty typologies would contribute to guiding specific care interventions. These typologies could additionally be related to different health outcomes. This study aims at identifying subgroups of frail older adults based on the physical frailty phenotype and examining the relationships of these frailty profiles with quality of life and perceived health. Methods: This study relies on data from the SHARE project, namely a representative sample of 1765 Spanish-dwelling older adults identified as frail or pre-frail. Analysis included general descriptive statistics, exploratory latent class analysis (LCA) to determine the number of frailty subgroups, and LCA with covariates…

Profiles of Physical Fitness Risk Behaviours in School Adolescents from the ASSO Project: A Latent Class Analysis

2018

The aim of the present investigation was to describe profiles of adolescents&rsquo