Search results for " Classical"
showing 10 items of 301 documents
Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA.
2004
Primary defence against invading microorganisms depends on a functional innate immune system and the complement system plays a major role in such immunity. Deficiencies in one of the components of the complement system can cause severe and recurrent infections, systemic diseases, such as systemic lupus erythematosus (SLE) and renal disease. Screening for complement deficiencies in the classical or alternative complement pathways has mainly been performed by haemolytic assays. Here, we describe a simple ELISA-based format for the evaluation of three pathways of complement activation. The assays are based on specific coatings for each pathway in combination with specific buffer systems. We ha…
"Nel più fulgido scenario di colori” Goethe e la scoperta del paradiso a Napoli
2017
Dopo avere visitato Roma, nel febbraio del 1787, J.W. Goethe giungeva a Napoli dove: «l’atmosfera si faceva sempre più pura, ormai ci trovavamo in un’altra terra». Nella seconda metà del Settecento, in Europa il poeta di Francoforte rappresentava certamente il massimo fra i divulgatori del mito del paradiso a Napoli e in Campania, ma anche in Sicilia, e dunque nel Meridione d’Italia, sia per la loro rigogliosa e sempre verde natura sia per l’abbondanza delle loro antichità classiche. A Roma Goethe aveva pregustato i frutti di questo paradiso, ma è solo visitando Napoli e il suo territorio che realizza di essere in un altro mondo, totalmente diverso dai paesi del Nord. Il presente saggio ha …
Crosstalk of the plasma contact system with bacteria.
2012
Activation of the plasma contact system triggers several cascade systems such as the kallikrein-kinin system, the intrinsic pathway of coagulation, the classical complement cascade and the fibrinolytic system. Recent studies have shown a critical role of the contact system for arterial and venous thrombus formation and thromboembolic disease. In contrast, the function of the contact system for host-defense reactions and its physiological functions have remained enigmatic. Experimental animal studies and clinical data have linked the contact system to bacterial infections with implications for sepsis disease. The present review summarizes the role of the contact system and its activation for…
Il Dioniso delle "Baccanti" e i "piegatori di pini". Polivalenza di un'immagine leggendaria
2021
This paper investigates the mythical and ritual background of Dionysus’ representation as “fir-bender” in Euripides’ "Bacchae" (ll. 1061 ff.), in an attempt to shed light not only on the dramaturgical aspects of the tragic plot, but also on the cultural categories that make this representation intelligible to the Athenian audience at the end of the fifth century BC. Following Louis Gernet’s historical-anthropological approach based on the notion of "polyvalence des images", this paper aims to define a mythical pattern – the connection between the bending of a tree and the dismemberment of a human victim – already attested in the Attic legend of Theseus and Sinis, in which both characters se…
Involvement of complement pathways in patients with bacterial septicemia.
2007
The complement system is a major humoral portion of the innate immune system, playing a significant role in host defence against microorganisms. The biological importance of this system is underlined by the fact that at least three different pathways for its activation exist, the classical, the MBL and the alternative pathway. To elucidate the involvement of the classical and/or the MBL pathway during bacterial septicemia, 32 patients with gram-positive and 30 patients with gram-negative bacterial infections were investigated. In patients with gram-positive bacteria, a significant consumption of C1q (p=0.005) but not of mannose-binding lectin (MBL) (p=0.2) was found during the acute phase o…
Monetary Plurality in Economic Theory
2018
The objective of this article is to identify the monetary plurality in economic theory. We will try to throw light on the way in which theories are attracted towards both unicity and plurality, and more specifically by unification and diversification of money. It should also be noted, in this respect, that the economics of money has undergone considerable development since the 1970s. A survey of the diverse theories, whether mainstream or not, static or dynamic, holistic or individualistic, will reveal the surprising amount of attention devoted to the problem of monetary unicity and/or plurality. We base our presentation on two lines of thought: -The first of these lines concerns a situatio…
Reward-related limbic memory and stimulation of the cannabinoid system: An upgrade in value attribution?
2018
While a lot is known about the mechanisms promoting aversive learning, the impact of rewarding factors on memory has received comparatively less attention. This research investigates reward-related explicit memory in male rats, by taking advantage of the emotional-object recognition test. This is based on the prior association, during conditioned learning, between a rewarding experience (the encounter with a receptive female rat) and an object; afterwards rat discrimination and recognition of the â emotional objectâ is recorded in the presence of a novel object, as a measure of positive limbic memory formation. Since endocannabinoids are critical for processing reward and motivation, the co…
Oxytocin prevents the increase of cocaine-related responses produced by social defeat
2019
The neuropeptide oxytocin (OXT) plays a critical role in the regulation of social and emotional behaviors. OXT plays a role in stress response and in drug reward, but to date no studies have evaluated its implication in the long-lasting increase of the motivational effects of cocaine induced by repeated social defeat (RSD). During the social defeat procedure, 1 mg/kg of OXT was administered 30 min before each episode of RSD. Three weeks after the last defeat, the effects of cocaine on the conditioned place preference (CPP), locomotor sensitization and the self-administration (SA) paradigms were evaluated. The influence of OXT on the levels of BDNF in the prefrontal cortex (PFC), striatum an…
Sex-dependent effects of early maternal deprivation on MDMA-induced conditioned place preference in adolescent rats: Possible neurochemical correlates
2013
Abstract The early neonatal stage constitutes a sensitive period during which exposure to adverse events can increase the risk of neuropsychiatric disorders. Maternal deprivation (MD) is a model of early life stress that induces long-term behavioural and physiological alterations, including susceptibility to different drugs of abuse. In the present study we have used the conditioned place preference (CPP) paradigm to address the influence of MD on the rewarding effects of 3,4-methylenedioxymetamphetamine (MDMA) in adolescent animals of both sexes. We have previously observed in adolescent rats that MD induces modifications in the serotonergic and endocannabinoid systems, which play a role i…
Effects of ketosis on cocaine-induced reinstatement in male mice;
2022
In recent years, the benefits of the ketogenic diet (KD) on different psychiatric disorders have been gaining attention, but the substance abuse field is still unexplored. Some studies have reported that palatable food can modulate the rewarding effects of cocaine, but the negative metabolic consequences rule out the recommendation of using it as a complementary treatment. Thus, the main aim of this study was to evaluate the effects of the KD on cocaine conditioned place preference (CPP) during acquisition, extinction, and reinstatement. 41 OF1 male mice were employed to assess the effects of the KD on a 10 mg/kg cocaine-induced CPP. Animals were divided into three groups: SD, KD, and KD af…