Search results for " Color"

Cholesterol-Inulin Conjugates for Efficient SN38 Nuclear Delivery: Nanomedicines for Precision Cancer Therapy

2022

An amphiphilic inulin-thiocholesterol conjugate (INU-Cys-TC) was strategically designed as a biodegradable core-shell nanocarrier of 7-ethyl-10-hydroxy-camptothecin (SN38) to enhance its solubility and stability in aqueous media, thus exploiting its brilliant anticancer effect. INU-Cys-TC was designed to have the hydrophilic inulin backbone (external shell) partially functionalized with hydrophobic thiocholesterol moieties (internal core) through a biodegradable disulfide bond due to cysteamine bridges. Thiocholesterol moieties impair redox-sensitive self-assembling abilities, yielding to nano-sized micelles in aqueous media capable of efficiently encapsulating a high amount of SN38 (DL = 8…

HSP110 promotes colorectal cancer growth through STAT3 activation.

2017

IF 7.932; International audience; Heat shock protein 110 (HSP110) is induced by different stresses and, through its anti-apoptotic and chaperoning properties, helps cells survive these adverse situations. In colon cancers, HSP110 is abnormally abundant. We have recently shown that colorectal cancer patients with microsatellite instability (MSI) had an improved response to chemotherapy because they harbor an HSP110-inactivating mutation (HSP110DE9). In this work, we used patient biopsies, human colorectal cancer cells grown in vitro and in vivo (xenografts), and intestinal crypts to demonstrate that HSP110 is also involved in colon cancer growth. We showed that HSP110 induces colon cancer ce…

HSP110 : role in colorectal cancer development and immunogenicity

2015

Our team studies HSPs, including HSP110. HSPs are chaperones involved in the folding of newly synthesized and denatured proteins. HSPs are overexpressed under stress conditions and are involved in cell survival thanks to their anti-apoptotic and anti-aggregation functions. HSP110 is overexpressed in colorectal cancer and is associated with a poor prognosis. The expression of a mutant HSP110, named HSP110DE9, has been shown in MSI colorectal cancer. This one was shown to act there as a dominant negative, by binding HSP110 and inhibiting its functions. Its expression sensitizes cancer cells to chemotherapy and is associated with a better prognosis for patients.I was first interested in HSP110…

Ruolo della granulometria sul colore dei pigmenti

2014

Monochromatic Long-Period Seismicity Prior to the 2012 Earthquake Swarm at Little Sitkin Volcano, Alaska

2021

Detection of the earliest stages of unrest is one of the most challenging and yet critically needed aspects of volcano monitoring. We investigate a sequence of five unusual long-period (LP) earthquakes that occurred in the days prior to the onset of a months-long volcano-tectonic (VT) earthquake swarm beneath Little Sitkin volcano in the Aleutian Islands during late 2012. The long-period earthquakes had two distinctive characteristics: their signals were dominated by a monochromatic spectral peak at approximately 0.57 Hz and they had impulsive P and S-wave arrivals on a seismometer located on Amchitka Island 80 km to the southeast of the volcano. In each case, the monochromatic earthquakes …

Il bianco e l'oro

2019

Giacomo Serpotta (1656-1732) was a brilliant and highly skilled master of the sculptural art of stucco throughout Europe. He was born in poverty in Palermo, and his father was imprisoned shortly after he was born. The canonical critic and historian Antonio Mongitore praised him for his work and for his confident and almost frantic style of drawing, and for his considerable dilicatezza (sensitivity). He defined Serpottaan“outstandingstuccoist”.Asimilaropinion comes from abbot Gioacchino Di Marzo, who greatly praised Serpotta in his essential essay entitled “The Gaginis and sculpture in Sicily”, published in 1980, and recognised the undoubted influence of the Gagini school, which began with h…

The Use of Opuntia ficus-indica Mucilage and Aloe arborescens as Edible Coatings to Improve the Physical, Chemical, and Microbiological Properties of…

2022

Edible coatings (EC) with mucilage of Opuntia ficus-indica or Aloe arborescens are promising to extend the shelf life of fresh-cut fruit products by reducing weight loss and microbial spoilage. In this work, fresh-cut kiwifruits (cv. Hayward) were coated in solutions with mucilage extracted from Opuntia ficus-indica (MC) and A. arborescens (AL). We used three alternative treatments with AL or MC, MC+AL, and with distilled water as control, and stored in passive atmosphere at 5 °C for 3, 5, 7, and 9 d, respectively. For all treatments at each storage period, firmness, weight loss, color, visual quality score, respiration rate, pectin content, and microbiological characteristics were observed…

Foliar Applications with SUNRED® Biostimulant Advance and Uniform Fruit Ripening in Orange and Olive

2015

This study evaluated the effect of foliar biostimulants on fruit quality of adult 'Valencia' orange and 'Biancolilla' olive trees. Half of the selected orange and olive trees were sprayed twice before harvest with the SUNRED® commercial mix containing phenylalanine, methionine, mono-saccharides and oxylipins from plant extracts as well as potassium salts and urea. Orange and olive yields and fruit quality were measured at harvest, and fruit peel color was determined by digital image analysis. Phenolic and sensory profiles were also determined in the olive oil. In orange, the foliar spray increased TSS:acid ratio and peel color uniformity, while in olive, it increased peel color uniformity, …

Quality changes in fresh-cut mango cubes submitted to different gas partial pressure of active MAPs

2018

The study was performed to assess chemical-physical and sensory quality changes in 4±1°C stored fresh-cut mangos and to test the effect of active modified atmosphere packaging (MAP) with different gas partial pressures. Sicilian fruits of ‘Keitt’ mango (Mangifera indica L.) were immerged in hydrogen peroxide (H2O2) after being peeled. Next, the flesh was cut in cubes and dipped in citric acid (0.5%, w/v) and ascorbic acid (0.5%, w/v). Treated fruits were placed in a non-perforated high density polyethylene package flushing different gas mixtures and kept at 4°C for 21 days. We used four different gas partial pressures: a) 60 kPa N2, 30 kPa CO2 and 10 kPa O2; b) 30 kPa CO2 and 70 kPa N2; c) …

Qualitative traits and shelf life of fig fruit (cv Melanzana) treated with Aloe vera gel coating

2021

The fig (Ficus carica L.) cv Melanzana is typical of Southern Italy. This cultivar produces breba fruit in June and fig fruit in August. Some previous studies on the use of coatings extracted from stems of Aloe vera showed positive effects to maintain fruit quality during shelf life. However, there are no studies on breba fig fruit treated with Aloe vera coating. In this study breba fig fruit, cv Melanzana, was treated with an application of Aloe vera gel, sealed in macro-perforated bag and stored at 5°C for 10 days. The effect of application of the Aloe vera gel on the shelf-life of this fruit, and its quality attributes after application were evaluated measuring fresh weight, total solubl…