Search results for " Colore"
showing 10 items of 235 documents
Dynamic regulation of the cancer stem cell compartment by Cripto-1 in colorectal cancer.
2015
Stemness was recently depicted as a dynamic condition in normal and tumor cells. We found that the embryonic protein Cripto-1 (CR1) was expressed by normal stem cells at the bottom of colonic crypts and by cancer stem cells (CSCs) in colorectal tumor tissues. CR1-positive populations isolated from patient-derived tumor spheroids exhibited increased clonogenic capacity and expression of stem-cell-related genes. CR1 expression in tumor spheroids was variable over time, being subject to a complex regulation of the intracellular, surface and secreted protein, which was related to changes of the clonogenic capacity at the population level. CR1 silencing induced CSC growth arrest in vitro with a …
Characteristics of the colorectal cancers diagnosed in the early 2000s in Italy. Figures from the IMPATTO study on colorectal cancer screening
2015
The impact of organized screening programmes on colorectal cancer (CRC) can be observed at a population level only several years after the implementation of screening. We compared CRC characteristics by diagnostic modality (screen-detected, non-screen-detected) as an early outcome to monitor screening programme effectiveness. Data on CRCs diagnosed in Italy from 2000 to 2008 were collected by several cancer registries. Linkage with screening datasets made it possible to divide the cases by geographic area, implementation of screening, and modality of diagnosis (screen-detected, non-screen-detected).We compared the main characteristics of the different subgroups of CRCs through multivariate …
Context matters-consensus molecular subtypes of colorectal cancer as biomarkers for clinical trials
2019
Abstract The Colorectal Cancer Subtyping Consortium identified four gene expression consensus molecular subtypes, CMS1 (immune), CMS2 (canonical), CMS3 (metabolic), and CMS4 (mesenchymal), using multiple microarray or RNA-sequencing datasets of primary tumor samples mainly from early stage colon cancer patients. Consequently, rectal tumors and stage IV tumors (possibly reflective of more aggressive disease) were underrepresented, and no chemo- and/or radiotherapy pretreated samples or metastatic lesions were included. In view of their possible effect on gene expression and consequently subtype classification, sample source and treatments received by the patients before collection must be ca…
Introduzione
2017
Nella cornice del Piano Colore Isole Egadi, il convegno internazionale “Identity | The Colors of Project” evidenzia il ruolo strategico dell’identità – di un’istituzione, di un’azienda, di un territorio – con particolare riferimento alle connotazioni identificative del colore. Qui, studiosi con competenze disciplinari diverse si confrontano sul tema spaziando in ambiti molto diversi: dal prodotto al cibo, dal web al car design, dalla fotografia alla brand identity.
Evaluation and management of hemorrhoids: Italian society of colorectal surgery (SICCR) consensus statement
2015
Hemorrhoids are one of the most common medical and surgical diseases and the main reason for a visit to a coloproctologist. This consensus statement was drawn up by the Italian society of colorectal surgery in order to provide practice parameters for an accurate assessment of the disease and consequent appropriate treatment. The authors made a careful search in the main databases (MEDLINE, PubMed, Embase and Cochrane), and all results were classified on the basis of the grade of recommendation (A-C) of the American College of Chest Physicians.
LA VALUTAZIONE DELLA DURABILITÀ DI INTONACI FOTOCATALITICI
2014
Energy saving and the rational use of natural resources in the building process, nowadays, are very debated environmental issues, involving researchers and companies in the production and testing of innovative materials. Reducing the consumption of resources means more durable buildings, thus an important contribution in this way is given by the knowledge of the durability of products and building components. This is fundamental when innovative products are applied and no information are available on their service life. The research concerns the evaluation of the durability of cement-based photocatalytic coatings, containing different types of pigments, used for external finishing of buildi…
Valutazione sperimentale della durabilità di intonaci finalizzata alla manutenzione programmata
2010
La Legge 109/94 ha imposto per i nuovi interventi pubblici, la programmazione della manutenzione da redigersi in fase di progettazione esecutiva. La fase di gestione del bene edilizio assume, infatti, un’importanza strategica, nell’ottica di una ragionevole durata di vita utile espletata in un equilibrato rapporto qualità-costo globale, per la sostenibilità dell’intervento. Un contributo in tal senso è costituito dal contenimento nel consumo di risorse e di materie prime conseguibile attraverso il miglioramento del requisito di durabilità dell’edificio e delle sue parti, cosa possibile se si conosce il comportamento nel tempo di componenti e sistemi edilizi contestualizzati. Ciò vale anche …
A proposal for an evidence-based model of the screening for the colorectal carcinoma in an Italian setting
2011
Introduction. The aim of this paper is to improve the feasibility perception of policymakers, health care workers and target population about the cost-effectiveness of the implementation of colorectal screening as Public Health strategy. Methods. Retrospective study by application of a three-step model designed for a local setting in Sicily (Palermo and its Province) in order to distribute Fecal Occult Blood Tests (FOBTs), offer colonoscopy and surgery, by district allocation of pharmacies, public digestive endoscopic centres and oncologic and general surgery units. Mean adherence to consolidated colorectal screening programs in Italy was applied in order to evaluate the feasibility of an o…
Colorectal cancer defeating? Challenge accepted!
2013
Colorectal tumours are actually considered as aberrant organs, within it is possible to notice a different stage of cell growth and differentiation. Their origin is reported to arise from a subpopulation of tumour cells endowed with, just like the healthy stem cells, self-renewal and aberrant multi-lineage differentiation capacity likely to be called colorectal cancer stem cells (CCSCs). Cancer stem cells (CSCs) fate, since their origin, reflects the influences from their microenvironment (or niche) both in the maintenance of stemness, in promoting their differentiation, and in inducing epithelial-mesenchymal transition, responsible of CSCs dissemination and subsequent formation of metastat…