Search results for " Combination"

showing 10 items of 923 documents

Lipid-Altering Efficacy of Ezetimibe/Simvastatin 10/20 mg Compared to Rosuvastatin 10 mg in High-Risk Patients with and without Type 2 Diabetes Melli…

2010

AIMS: This post hoc analysis compared the effects of switching to ezetimibe/simvastatin 10/20 mg (EZE/SIMVA) or rosuvastatin 10 mg (ROSUVA) in uncontrolled high-risk hypercholesterolemic patients with/without type 2 diabetes mellitus (T2DM) despite statin monotherapy. METHODS: Patients (n = 618) at high risk for coronary vascular disease with elevated LDL-C ≥100 and ≤190 mg/dL despite use of statins were randomized 1:1 to double-blind EZE/SIMVA 10/20 mg or ROSUVA 10 mg for 6 weeks. Patients were classified as having T2DM based on ≥1 of the following: diagnosis of T2DM, antidiabetic medication, or FPG ≥126 mg/dL. This analysis evaluated percent changes from baseline in lipids among patients …

SulfonamidesSimvastatinSettore MED/09 - Medicina InternaAnticholesteremic AgentsHypercholesterolemiaDrug ResistanceCholesterol LDLEzetimibeLipidsFluorobenzenesC-Reactive ProteinCholesterolPyrimidinesDiabetes Mellitus Type 2Double-Blind MethodOdds RatioDiabetes MellitusAzetidinesHumansDrug Therapy CombinationHydroxymethylglutaryl-CoA Reductase InhibitorsRosuvastatin CalciumApolipoproteins B
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Simulation of tungsten tip-Al(100) surface electronic structure through LCAO-LSD calculations

1997

Surface (mathematics)chemistryLinear combination of atomic orbitalschemistry.chemical_elementElectronic structurePhysical and Theoretical ChemistryAtomic physicsTungstenCondensed Matter PhysicsAtomic and Molecular Physics and OpticsInternational Journal of Quantum Chemistry
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The Use of a Surgical Patch in the Prevention of Lymphoceles After Extraperitoneal Pelvic Lymphadenectomy for Prostate Cancer: A Randomized Prospecti…

2009

Purpose: Pelvic lymphadenectomy is frequently performed simultaneously with radical prostatectomy to determine lymph node status and the most frequently recorded postoperative complication is the development of a symptomatic lymphocele. This study evaluated TachoSil® as an adjunct treatment in preventing lymphoceles after extraperitoneal pelvic lymphadenectomy for prostate cancer. Materials and Methods: A total of 60 consecutive patients who had undergone radical prostatectomy and pelvic lymphadenectomy were prospectively enrolled in this study. The patients were randomly assigned to a standard technique with the use of clips and electrocoagulation plus TachoSil, or to standard technique on…

Surgical SpongesMalemedicine.medical_specialtyUrologymedicine.medical_treatmentLymphocelePilot Projectscomplicationlymph node excisionLymphoceleDrug CombinationmedicineHumansPilot ProjectSingle-Blind MethodSurgical SpongeProspective StudiesProspective cohort studyPelvisprostatectomybusiness.industryProstatectomyThrombinProstatic NeoplasmsPostoperative complicationFibrinogenpelviTachoSilMiddle Agedmedicine.diseaseSurgeryDrug CombinationsProspective Studiemedicine.anatomical_structureProstatic NeoplasmLymphadenectomybusinessRadical retropubic prostatectomyHuman
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Induction of tumor peptide-specific cytotoxic T cells under serum-free conditions by mature human dendritic cells

2000

Tumor vaccination strategies using antigen-pulsed dendritic cells (DC) are currently under development. We established an in vitro system using cultured DC from HLA-typed volunteers for the induction of tumor peptide-specific CD8+ T cells. The strength and specificity of the resulting CTL responses were investigated. For stimulation of syngeneic CD8+ T cells two well-defined DC populations were generated: CD1a+ immature DC cultured in the presence of GM-CSF and IL-4 and mature CD83+ DC generated by additional stimulation with a cytokine cocktail. Stimulations were performed under serum-free conditions and in the absence of exogenous cytokines. Analysis of T cell responses showed that mature…

T cellImmunoglobulinsPriming (immunology)DermatologyDendritic cell differentiationCD8-Positive T-LymphocytesBiologyCulture Media Serum-FreeInterleukin 21Antigens CDmedicineHumansCytotoxic T cellCells CulturedCellular SenescenceMembrane GlycoproteinsCell DifferentiationDendritic CellsGeneral MedicineDendritic cellMolecular biologyNeoplasm ProteinsDrug CombinationsCTL*medicine.anatomical_structureImmunologyCytokinesCD8T-Lymphocytes Cytotoxic
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Taxonomic remarks onHieracium sartorianumvar.lucanicum(Asteraceae), a little known taxon of Cilento (Campania, southern Italy)

2015

Hieracium sartorianum var. lucanicum, a little known taxon described from Mt Sacro (Parco Nazionale del Cilento e Vallo di Diano, Prov. of Salerno, Campania, Italy), is reexamined. As a result it is reclassified as a subspecies to H. hypochoeroides. A new combination and lectotypification are made and a detailed description is given.

TaxonHieraciumbiologyCampania Cilento Hieracium hypochoeroides Monte Sacro taxonomy new combinationSettore BIO/02 - Botanica SistematicaBotanyPlant ScienceAsteraceaeSubspeciesbiology.organism_classificationEcology Evolution Behavior and SystematicsNordic Journal of Botany
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Integrazione di celle fotovoltaiche ibride nel vetromattone

2012

L’invenzione riguarda l’integrazione del vetromattone con celle solari ibride (organiche/inorganiche), conosciute come Dye-sensitized Solar Cell (DSC). La combinazione del vetromattone con le DSC consente di migliorare le prestazioni del prodotto originario rendendolo in grado di produrre energia pulita. Le caratteristiche di trasparenza e isolamento termo-acustico del prodotto possono essere regolate agendo sulla configurazione delle DSC. Il prodotto può essere assemblato a formare pannelli fotovoltaici per la realizzazione di facciate traslucide energeticamente “attive” in varie condizioni luminose (condizioni di luce diffusa o artificiale) e indipendentemente dall’angolo di radiazione so…

The integration of Dye-sensitized Solar Cell (DSC) with the glassblock is disclosed. The combination of the two technological elements the glassblock and the DSC module enhance their own peculiarities. The final complete product is ready-made for installation owns the qualities of the glassblock and produces sustainable energy at the same time. The transparency and the thermo-acoustic insulation may be modulated according to the specific requirements of each case of installation. The product may be used for example to create PV panels for glazed and translucent façades that are able to perform efficiently in all light conditions (even in diffuse light also converting internal artificial light) that are not dependant on the angle of the solar radiation and do not suffer from the high operative temperatures of functioning due to the peculiarities of the DSCs. DSCs are made of economic and biocompatible materials and are produced with low-cost and highly productive printing methods on rigid or flexible substrates. With the integration of DSC modules with the glassblock PV panels coincide with the envelope itself so that they do not need any further structures to be installed on and allow the possibility of subtract from the price of the panel the price of the substituted building element allowing further economies. DSCs can be printed in different colours and with various patterns offering to designers and customers the possibility of intervening on the glassblock aesthetical aspect also taking advantage of the peculiar modularity of the glassblock for larger compositions of drawings on the building’s façade. Seven Hypotheses of integration are discussed in order to obtain DSC-integrated glassblock ready for the construction of a precast and dry-assembled PV panel which can use the horizontal and vertical cavities between the glassblocks to house plastic profiles where the electric interconnections and the steel bars -useful for improve the mechanical resistance of the panel- are integrated.Settore ICAR/10 - Architettura Tecnica
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Canopy Architecture Appraisal by Fractal Dimension of 'Flordastar' Peach Trees Grafted onto Different Rootstocks

2007

The objective of this research was to evaluate the modification of canopy architecture of ''Flordastar'' peach (Prunus persica L. Batsch) grafted onto rootstocks with different vigour, by the use of fractal dimension (D). The hypothesis was that different vigour rootstocks are able to modify the complexity of the branching pattern and that this effect can be assessed by a geometric parameter such as the fractal dimension (D) of the 2D projection of tree branching structure. The observations were carried out in a four-year-old experimental orchard of cv. ''Flordastar'' peach trees grafted onto Ishtara, Barrier, GF677 and MrS 2/5 rootstocks. On digital pictures of leafless, dormant peach tree…

The objective of this research was to evaluate the modification of canopy architecture of ''Flordastar'' peach (Prunus persica L. Batsch) grafted onto rootstocks with different vigour by the use of fractal dimension (D). The hypothesis was that different vigour rootstocks are able to modify the complexity of the branching pattern and that this effect can be assessed by a geometric parameter such as the fractal dimension (D) of the 2D projection of tree branching structure. The observations were carried out in a four-year-old experimental orchard of cv. ''Flordastar'' peach trees grafted onto Ishtara Barrier GF677 and MrS 2/5 rootstocks. On digital pictures of leafless dormant peach trees the tree skeleton was manually depicted by an image analysis software to measure total length and angles of insertion of branches. Bitmaps of the skeleton were then subjected to a specific software (FDCALC) able to calculate D by the "box counting" method. To account for the error introduced by analyzing a three dimensional structure with its 2D projection measurements were done on two images per tree taken from two different viewing angles. Results are shown in relation to tree vigour of the scion/stock combination. Fractal dimension was related to the vigour ranking of the graft combinations tested. In particular vigorous scion/stock combinations showed the highest D.HorticultureCanopy architectureHorticultureRootstockFractal dimensionMathematics
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A critical evaluation of caplacizumab for the treatment of acquired thrombotic thrombocytopenic purpura

2020

Introduction: Acquired thrombotic thrombocytopenic purpura (aTTP) is a thrombotic microangiopathy caused by inhibitory autoantibodies against ADAMTS13 protein. Until recently, the combination of plasma exchange (PEX) and immunosuppression has been the standard front-line treatment in this disorder. However, aTTP-related mortality, refractoriness, and relapse are still a matter of concern. Areas covered: The better understanding of the pathophysiological mechanisms of aTTP has allowed substantial improvements in the diagnosis and treatment of this disease. Recently, the novel anti-VWF nanobody caplacizumab has been approved for acute episodes of aTTP. Caplacizumab is capable to block the adh…

Thrombotic microangiopathyExacerbationvirusesmedicine.medical_treatmentADAMTS13 ProteinDiseaseBioinformaticsAutoantigens03 medical and health sciencesPlatelet Adhesiveness0302 clinical medicineFibrinolytic AgentsProtein DomainsCrotalid Venomsvon Willebrand FactormedicineHumansImmunologic FactorsMulticenter Studies as TopicLectins C-TypeMolecular Targeted TherapyDrug ApprovalClinical Trials as TopicAcquired Thrombotic Thrombocytopenic PurpuraPlasma ExchangePurpura Thrombotic Thrombocytopenicbusiness.industryStandard treatmentfungiImmunosuppressionDrugs InvestigationalHematologyAptamers NucleotideSingle-Domain Antibodiesbiochemical phenomena metabolism and nutritionmedicine.diseaseCombined Modality TherapyRecombinant ProteinsADAMTS13AcetylcysteineTreatment Outcome030220 oncology & carcinogenesisDrug Therapy CombinationCaplacizumabbusinessImmunosuppressive Agents030215 immunologyExpert Review of Hematology
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Cytotoxicity and bioactivity of various pulpotomy materials on stem cells from human exfoliated primary teeth.

2017

Aims To investigate the cytotoxicity and bioactivity of several pulpotomy materials: Biodentine (Septodont, Saint-Maur-des-Fosses, France) MTA (Angelus, Londrina, PR, Brazil), Theracal LC (Bisco Inc., Schamburg, IL, USA) and IRM (Dentsply DeTrey GmbH, Konstanz, Germany), after contact with stem cells isolated from human exfoliated primary teeth (SHEDs). Methodology SHEDs were cultured in the presence of the eluates of various pulpotomy materials for 24, 48 and 72 h. Cell viability was determined by mitochondrial dehydrogenase enzymatic (MTT) assay. Apoptosis and changes in cell phenotype were evaluated by flow cytometry. Also, an in vitro scratch wound-healing assay was used to determine th…

Time FactorsCell SurvivalPulpotomyDentistryApoptosis02 engineering and technologyMatrix (biology)In Vitro TechniquesCell morphologyFlow cytometry03 medical and health sciences0302 clinical medicineCell MovementMaterials TestingmedicineHumansMethylmethacrylatesViability assayTooth DeciduousZinc Oxide-Eugenol CementCytotoxicityAluminum CompoundsGeneral DentistryCells Culturedmedicine.diagnostic_testChemistrybusiness.industrySilicatesStem CellsOxides030206 dentistryCalcium Compounds021001 nanoscience & nanotechnologyFlow CytometryMolecular biologyStainingDrug CombinationsPhenotypeApoptosisPulpotomyMicroscopy Electron Scanning0210 nano-technologybusinessPulp Capping and Pulpectomy AgentsInternational endodontic journal
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Management of HCV-Related Liver Disease in Hemophilia and Thalassemia

2018

AbstractChronic infection with the hepatitis C virus (HCV) has long been the dominant complication of substitution therapy in patients with inherited blood disorders and the cause of anticipated death due to end-stage liver disease. In hemophilia, transmission of HCV with clotting factors concentrates started to be curbed in the mid-1980s following the adoption of procedures of virus inactivation of concentrates based on heat, whereas in the 1990s treatment of HCV infection with interferon monotherapy was attempted, however, with little success. The advent of combination therapy of interferon with ribavirin led to a substantial improvement of treatment outcome (40% rate of cure), that howev…

Time FactorsTime FactorThalassemiaHepatitis C virusPopulationAdministration Oral030204 cardiovascular system & hematologyHemophilia Amedicine.disease_causeAntiviral Agents03 medical and health scienceschemistry.chemical_compoundLiver disease0302 clinical medicinesickle cell anemiaRisk FactorshemophiliamedicineHumansBlood TransfusioneducationImmunodeficiencyAntiviral AgentClotting factoreducation.field_of_studydirect antiviral agentHepatologybusiness.industryRisk FactorRibavirinHepatitis CHepatitis C Chronicmedicine.diseaseTreatment OutcomechemistryImmunologyThalassemiaDrug Therapy Combination030211 gastroenterology & hepatologyhepatitis CbusinessHumanSeminars in Liver Disease
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