Search results for " Comparative"
showing 10 items of 657 documents
Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression
2022
ABSTRACTAnimal models recapitulating distinctive features of severe COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2) represent a lethal model of SARS-CoV-2 infection. The precise mechanisms of lethality in this mouse model remain unclear. Here, we evaluated the spatiotemporal dynamics of SARS-CoV-2 infection for up to 14 days post-infection. Despite infection and moderate pneumonia, rapid clinical decline or death of mice was invariably associated with viral neuroinvasion and direct neuronal injury (including brain and spinal neurons). Neuroinv…
Development of “universal” gene-specific markers from Malus spp. cDNA sequences, their mapping and use in synteny studies within Rosaceae
2009
The Rosaceae contains many economically valuable crop genera, including Malus (apple), Fragaria (strawberry), and Prunus (stone fruit). There has been increasing interest in the development of linkage maps for these species, with a view to marker-assisted selection to assist breeding programs and, recently, in the development of transferable markers to permit syntenic comparisons of maps of different rosaceous genera. In this investigation, a set of Malus cDNA sequences were downloaded from the European Molecular Biology Laboratory database. The sequences were aligned with homologous full-length Arabidopsis genomic DNA sequences to identify putative intron–exon junctions and conserved flank…
Genetic Variability of Hepatitis C Virus before and after Combined Therapy of Interferon plus Ribavirin
2008
We present an analysis of the selective forces acting on two hepatitis C virus genome regions previously postulated to be involved in the viral response to combined antiviral therapy. One includes the three hypervariable regions in the envelope E2 glycoprotein, and the other encompasses the PKR binding domain and the V3 domain in the NS5A region. We used a cohort of 22 non-responder patients to combined therapy (interferon alpha-2a plus ribavirin) for which samples were obtained before initiation of therapy and after 6 or/and 12 months of treatment. A range of 25-100 clones per patient, genome region and time sample were sequenced. These were used to detect general patterns of adaptation, t…
Il Cabinet d'amateur di Georges Perec
2011
In 1979 one year after the publication of La vie mode d’emploi, George Perec wrote Cabinet d’amateur. Histoire d’un tableau, in which he tells the story of a painting belonging to the genre of the cabinet d’amateur, also known as kunst- und wunderkammer. It is a collection of different paintings, usually belonging to a rich man or a notable, portrayed (once again) in a single picture celebrating the magnificence of this more or less real collection. As for the pictorial genre, so the short novel is the celebration of the images collected by George Perec in his previous masterpiece, La vie mode d’emploi. This is why I assume this work to be referable to the genre of structural homology more …
Utilizing Multimodal Data Through fsQCA to Explain Engagement in Adaptive Learning
2020
Investigating and explaining the patterns of learners’ engagement in adaptive learning conditions is a core issue towards improving the quality of personalized learning services. This article collects learner data from multiple sources during an adaptive learning activity, and employs a fuzzy set qualitative comparative analysis (fsQCA) approach to shed light to learners’ engagement patterns, with respect to their learning performance. Specifically, this article measures and codes learners’ engagement by fusing and compiling clickstreams (e.g., response time), physiological data (e.g., eye-tracking, electroencephalography, electrodermal activity), and survey data (e.g., goal-orientation) to…
The Role of the Prefect in the Italian Legal System
2014
Any approach to the prefectoral institute, as it appears today as result of the recent changes introduced in the Italian legal system over the last years, cannot be reconstructed by starting from government representation, and consequently, from the fundamental character of several competences of the Prefect in Italy in the light of the deep reforms of the Italian public administration in the perspective of the “multi-level constitutionalism” the progressive emergence and developments of organs, structure and procedures that create legal norms and impose such norms on citizens of different national states3.
El derecho de los parlamentarios a recabar documentación administrativa. Nuevas perspectivas jurisprudenciales a raíz de su creciente judicialización
2019
For just over five years, for the first time in our democratic history, the right of parliamentarians to collect documentation from public administrations has been judicialized in the contentious-administrative way. A cluster of cases with a single common focus: tense government-parliament relations in the Valencian Community. This conflict has led, in the course of these years, to a high number of resolutions of both the Superior Court of Justice of the Valencian Community and the Supreme Court. A total of more than forty sentences that have had a considerable impact on the delimitation of this right. This article examines these judicial resolutions and offers a global analysis of the inte…
T-pattern detection and analysis for the discovery of hidden features of behaviour
2018
Abstract Background The behaviour of all living beings consists of hidden patterns in time; consequently, its nature and its underlying dynamics are intrinsically difficult to be perceived and detected by the unaided observer. Method Such a scientific challenge calls for improved means of detection, data handling and analysis. By using a powerful and versatile technique known as T-pattern detection and analysis (TPA) it is possible to unveil hidden relationships among the behavioural events in time. Results TPA is demonstrated to be a solid and versatile tool to study the deep structure of behaviour in different experimental contexts, both in human and non human subjects. Conclusion This re…
THE ROLE OF ACCOUNTABILITY WITHIN A ZERO WASTE STRATEGY: EVIDENCES FROM A SICILIAN SMALL MUNICIPALITY
2017
Building a sustainable city model comprising an integrated waste management system has become an indispensable choice, also in the light of increasingly stringent regulatory constraints. The core point of the paper is the implementation of a zero waste strategy in a small municipality in Sicily. Given that only the unceasing participation of citizens may ensure the persistence over time of such a policy, accountability process works letting citizens approach directly the end-results of their ongoing good practices. By building up a SD model framed by a DPM chart, it is possible to figure out how disclosure of public saving resulting from the decreasing amount of waste piled up in the landfi…
Necessidade do controlar de oficio as cláusulas abusivas nos contratos com consumidores: Estudo comparado com o sistema espanhol
2016
Las autoridades europeas abogan por dotar al juez de mayores facultades para controlar ex officio la inclusión de cláusulas abusivas en los contratos de adhesión celebrados entre empresarios y consumidores. Una línea jurisprudencial incorporada en España, mejorando así la tutela y protección de los derechos e intereses de los consumidores. No obstante, países como Uruguay no contemplan esta posibilidad, impidiendo al juez realizar un control de contenido cuando no haya sido solicitado por las partes puesto que se cuestiona su anulación debido a la propia naturaleza de la nulidad. En el presente artículo analizamos las diferentes regulaciones de las cláusulas abusivas en los ordenamientos es…