Search results for " Complement"

The cell adhesion domain of type XVII collagen promotes integrin-mediated cell spreading by a novel mechanism.

2001

Type XVII collagen (BP180) is a keratinocyte transmembrane protein that exists as the full-length protein in hemidesmosomes and as a 120-kDa shed ectodomain in the extracellular matrix. The largest collagenous domain of type XVII collagen, COL15, has been described previously as a cell adhesion domain (Tasanen, K., Eble, J. A., Aumailley, M., Schumann, H., Baetge, J, Tu, H., Bruckner, P., and Bruckner-Tuderman, L. (2000) J. Biol. Chem. 275, 3093-3099). In the present work, the integrin binding of triple helical, human recombinant COL15 was tested. Solid phase binding assays using recombinant integrin alpha(1)I, alpha(2)I, and alpha(10)I domains and cell spreading assays with alpha(1)beta(1)…

Kininogen binding protein p33/gC1qR is localized in the vesicular fraction of endothelial cells

1996

AbstractThe endothelial protein p33/gC1qR is thought to mediate the assembly of components of the kinin-forming and complement-activating pathways on the surface of cardiovascular cells. FACS analysis of intact human umbilical vein endothelial cells using specific antibodies to p33 revealed a minor fluorescence on the cell surface whereas permeabilized cells showed a bright fluorescence indicative of an intracellular localization of p33. Immunostaining of fixed cells confirmed the predominant intracellular localization of p33. Fractionation studies demonstrated that the vesicular but not the membrane fraction of EA.hy926 cells is rich in p33. We conclude that externalization of p33 must pre…

INVOLUTIONS ON KNOT GROUPS AND VARIETIES OF REPRESENTATIONS IN A LIE GROUP

2002

We prove the existence of a rationalisation [Formula: see text] of a classical or high-dimensional knot group Π which admits an involution if the Alexander polynomials of the knot are reciprocal. Using the group [Formula: see text] and its involution, we study the local structure, in the neighbourhood of an abelian representation, of the space of representation of the knot group Π in a a Lie group. We apply these results to the groups of classical prime knots up to 10 crossings.

Kronecker modules and reductions of a pair of bilinear forms

2004

We give a short overview on the subject of canonical reduction of a pair of bilinear forms, each being symmetric or alternating, making use of the classification of pairs of linear mappings between vector spaces given by J. Dieudonné.

The Correspondences of Luigi Cremona and Placido Tardy in the Libraries of Genoa

2018

We describe the historical framework and the main issues (biographical, scientific, political, etc.) of the correspondences of Placido Tardy and Luigi Cremona in the libraries of Genoa, which constitute an important contribution to the reconstruction of the History of Mathematics in the Italian “Risorgimento”. In particular, we mainly deal with the Cremona-Tardy, Betti-Tardy and Cremona-Guccia correspondences. Tardy’s letters are preserved at the Genoa University Library and Cremona’s letters at the Mazzini Institute of Genoa.

L'epicicloide: un viaggio tra la Storia e la Filosofia

2013

Maturation of epidermal Langerhans cells: increased expression of beta- and gamma-actin isoforms as a basis of specialized cell functions.

1999

Epidermal Langerhans cells (LC) represent immature dendritic cells. During in vitro culture in the presence of keratinocytes they mature into potent immunostimulatory cells for naive T cells. This process is thought to simulate in vivo maturation of LC following activation by antigen contact. Maturation of LC is accompanied by morphological alterations. Applying a differential screening procedure we isolated differentially expressed cDNAs involved in the maturation events including cDNAs of the cytoskeletal actin isoforms beta- and gamma-actin. Stronger signals with hybridization probes derived from cultured LC compared with probes derived from freshly isolated LC indicate upregulation of a…

Legislazione extracodicistica

2013

Voce enciclopedica ricostruttiva della legislazione extracodicistica e dei suoi rapporti con il codice penale.

Frictionless contact-detachment analysis: iterative linear complementarity and quadratic programming approaches.

2012

The object of the paper concerns a consistent formulation of the classical Signorini’s theory regarding the frictionless contact problem between two elastic bodies in the hypothesis of small displacements and strains. The employment of the symmetric Galerkin boundary element method, based on boundary discrete quantities, makes it possible to distinguish two different boundary types, one in contact as the zone of potential detachment, called the real boundary, the other detached as the zone of potential contact, called the virtual boundary. The contact-detachment problem is decomposed into two sub-problems: one is purely elastic, the other regards the contact condition. Following this method…

Functional Definition of a B Cell Epitope, KGEQGEPGA, on C1q the Fc-Binding Subunit of the First Component of Complement

1999

A synthetic peptide representing the C1q epitope KGEQGEPGA has been shown to suppress or delay the onset of CII-induced arthritis when applied intravenously (i.v.) prior to an intradermal (i.d.) challenge, in a mouse model; the phenomenon being associated with the development of immunoglobulin (Ig)M antibodies specific for the KGEQGEPGA epitope. Here we show that this amino acid sequence provides an immunodominant B cell epitope that is recognised by autoantibodies present in the sera of patients with chronic inflammatory diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, two diseases associated with an immune response to C1q. The peptide's ability to produce pept…