Search results for " Conditioning"

Most hippocampal CA1 pyramidal cells in rabbits increase firing during awake sharp-wave ripples and some do so in response to external stimulation an…

2020

Hippocampus forms neural representations of real-life events including multimodal information of spatial and temporal context. These representations, i.e. organized sequences of neuronal firing are repeated during following rest and sleep, especially when so-called sharp-wave ripples (SPW-Rs) characterize hippocampal local-field potentials. This SPW-R –related replay is thought to underlie memory consolidation. Here, we set out to explore how hippocampal CA1 pyramidal cells respond to the conditioned stimulus during trace eyeblink conditioning and how these responses manifest during SPW-Rs in awake adult female New Zealand White rabbits. Based on reports in rodents, we expected SPW-Rs to ta…

Hippocampal event-related potentials to tone-CS during classical conditioning of the rabbit nictitating membrane response

2004

Trace eyeblink conditioning and extinction contingent to hippocampal ripples in rabbits

2014

Rats with elevated genetic risk for metabolic syndrome exhibit cognitive deficiencies when young

2021

Metabolic syndrome (MetS) is a known risk factor for cognitive decline. Using polygenic rat models selectively bred for high and low intrinsic exercise capacity and simultaneously modelling as low and high innate risk factor for MetS respectively, we have previously shown that adult animals with lower exercise capacity/higher MetS risk perform poorly in tasks requiring flexible cognition. However, it is not known whether these deficits in cognition are present already at young age. Also, it is unclear whether the high risk genome is related also to lower-level cognition, such as sensory gating measured as prepulse inhibition. In this study, young and adult (5-8 weeks and ∼9 months) rats sel…

Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus.

2021

Abstract BACKGROUND Increasing evidence shows obesity and poor metabolic health are associated with cognitive deficits, but the mechanistic connections have yet to be resolved. We studied rats selectively bred for low and high intrinsic aerobic capacity in order to test the association between low physical fitness, a genetic predisposition for obesity, and brain health. We hypothesized that low-capacity runner (LCR) rats with concurrently greater levels of adiposity would have increased hippocampal inflammation and reduced plasticity compared to the more physically fit high-capacity runner (HCR) rats. METHODS We examined markers for inflammation and brain plasticity in the hippocampi of LCR…

Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats

2023

Good aerobic fitness associates positively with cognitive performance and brain health and conversely, low aerobic fitness predisposes to neurodegenerative diseases. To study how genotype together with exercise, started at older age, affects brain and behavior, we utilized rats that differ in inherited aerobic fitness. Rats bred for Low Capacity for Running (LCR) are shown to display less synaptic plasticity and more inflammation in the hippocampus and perform worse than rats bred for a High Capacity for Running (HCR) in tasks requiring flexible cognition. Here we used middle-aged (∼ 16 months) HCR and LCR rats to study how genotype and sex associate with anxiety and neural information filt…

Transkraniaalisen tasavirtastimulaation vaikutukset erottelu- ja käänteisoppimiseen sekä reagointiherkkyyden muutoksiin

2017

Transkraniaalisella tasavirtastimulaatiolla (tDCS) tarkoitetaan menetelmää, jossa johdetaan heikkoa sähkövirtaa aivokudosten läpi elektrodilta toiselle. Tutkimusten mukaan tDCS:lla näyttäisi olevan monenlaisia kliinisiä ja kognitiivisia vaikutuksia aina masennuksen hoidosta työmuistin parantamiseen. Tulokset ovat kuitenkin monin paikoin varsin ristiriitaisia, eikä stimulaation tarkoista vaikutusmekanismeistakaan olla päästy varmuuteen. Tässä tutkimuksessa halusimme tutkia kokeellisesti tDCS:n vaikutuksia erottelu- ja käänteisoppimiseen sekä reagointiherkkyyden muutoksiin silmäniskuehdollistumisen avulla. Kokeeseen osallistui 39 iältään 18-29-vuotiasta koehenkilöä. Tutkittavat jaettiin kahte…

Effect of energy density on liking and on caloric adjustment conditioning after sweet beverage exposure in children aged 8-11 y

2014

The contribution of sweet beverages to weight gain in children and adolescents is controversial. The present study was conducted to study, in 8-11 year-old children, the influence of energy conditioning on liking and on caloric adjustment after sweet beverages exposure. We also studied the stability of the conditioning effects after a period without exposure and an extinction period. Children (n = 44) were exposed to 2 flavored sweetened beverages: a high energy version (HE: 150kcal) and a no energy version (NE: 0kcal). During a 4-wk conditioning period, children were exposed either 2 or 7 times to each beverage. During a 3-wk stability period children were not exposed to any beverage. Duri…

Rapid changes in bodily and neural states affect learning

2018

Declarative memories consist of the past events and factual information that can be recalled. One of the most popular experimental paradigms used in studying long-term memory formation is classical conditioning. Trace conditioning is a hippocampus-dependent task where two separate sensory stimuli are presented in contingency but with a temporal gap between. In trace eyeblink conditioning a conditioned stimulus, usually a tone, is presented with a short silent period followed by an airpuff to the eye. In the beginning of the learning process the behavioral response to the airpuff is naturally a blink of an eye. After repeated trials the subject learns to shut the eyelid after perceiving the …

Effect of concurrent training on trainability performance factors in youth elite golf players

2020

Background Due to the early specialization of golf players, examining the within session sequence of training should be considered to enhance performance and prevent injury risk. The present study analyzed the effects of an 18-week concurrent training developed before or after a specific golf session in adolescence elite golfers on several performance factors. Methods Sixteen right-handed male golfers, were randomly divided into two groups: after golf specific training (AG) (n = 8, age: 16.77 ± 0.58 years) and before golf specific training (BG) (n = 8, age: 16.93 ± 0.59 years). AG and BG players followed a concurrent physical conditioning program (CT) after or before the golf specific trai…