Search results for " Control"

Psychopathologies des demandeurs d’asile en Europe, traumatisme et fonctionnement défensif

2015

Refugees seeking asylum are a particularly vulnerable population. It has been observed that among the most commonly-occurring disorders exhibited in this population, there is a high incidence of post-traumatic stress disorder, generalized anxiety disorder, and depression. These disorders may be linked to the difficult paths that refugees are forced to undertake, as well as to different traumatic events which are particularly destructive psychologically (deliberate physical, sexual and/or psychological violence, traumatic bereavements in the context of war, or social and political instability, socio-economic, familial or administrative difficulties), which compromise their view of their shor…

2016

BACKGROUND: While noise annoyance has become recognized as an important environmental stressor, its association to mental health has hardly been studied. We therefore determined the association of noise annoyance to anxiety and depression and explored the contribution of diverse environmental sources to overall noise annoyance. PATIENTS AND METHODS: We investigated cross-sectional data of n = 15.010 participants of the Gutenberg Health Study (GHS), a population-based, prospective, single-center cohort study in Mid-Germany (age 35 to 74 years). Noise annoyance was assessed separately for road traffic, aircraft, railways, industrial, neighborhood indoor and outdoor noise ("during the day"; "i…

Remdesivir for the Treatment of Hospitalised Patients with COVID-19 (DisCoVeRy): A Randomised, Controlled, Open-Label Trial

2021

Background: The antiviral efficacy of remdesivir is still controversial. We aimed at evaluating its clinical effectiveness in patients with COVID-19 requiring oxygen and/or ventilator support. Methods: In this European multicentre, open-label, parallel-group, randomised, controlled trial in adults hospitalised with COVID-19 (DisCoVeRy, NCT04315948; EudraCT2020-000936-23), participants were randomly allocated to receive usual standard of care alone or in combination with intravenous remdesivir (200 mg on day 1, then 100 mg once-daily for 9 days or until discharge). Treatment assignation was performed via web-based randomisation stratified on illness severity and administrative European regio…

Weitere Migräne-Studie der Modellvorhaben veröffentlicht: Effektivität der Akupunktur zur Prophylaxe der Migräne: eine multizentrische, randomisierte…

2006

Background Our aim was to assess the efficacy of a part-standardised verum acupuncture procedure, in accordance with the rules of traditional Chinese medicine, compared with that of part-standardised sham acupuncture and standard migraine prophylaxis with beta blockers, calcium-channel blockers, or antiepileptic drugs in the reduction of migraine days 26 weeks after the start of treatment. Methods This study was a prospective, randomised, multicentre, doubleblind, parallel-group, controlled, clinical trial, undertaken between April 2002 and July 2005. Patients who had two to six migraine attacks per month were randomly assigned verum acupuncture (n = 313), sham acupuncture (n = 339), or sta…

2018

IntroductionPersistent and distressing somatic symptoms are common in younger age cohorts such as university students. However, the majority does not receive adequate psychosocial care. Internet-based and mobile-based interventions may represent low threshold and effective extensions to reduce somatic and associated mental symptom severity. The planned study aims to investigate the feasibility and efficacy of an internet-based intervention in reducing somatic and psychological symptoms in an international population of university students with somatic symptom burden.Methods and analysisThis parallel two-armed randomised controlled trial evaluates an 8-week guided intervention, including web…

STUDIO E SVILUPPO DI MODELLI DI APPLICAZIONE DI EDUCAZIONE TERAPEUTICA AL PAZIENTE (ETP) IN BAMBINI CON PATOLOGIA RESPIRATORIA CRONICA

L’asma è una malattia cronica, molto frequente in età pediatrica, che può alterare significativamente la qualità della vita del bambino e della sua famiglia, se i suoi sintomi non sono sotto controllo. Ad oggi, perdura una diffusa ed ancora poco adeguata gestione della malattia a causa di interventi educazionali inidonei o, in alcuni casi, nonostante numerosi studi abbiano mostrato l’efficacia dell’Educazione Terapeutica nella gestione delle patologie croniche. Obiettivo: il progetto di ricerca si pone l’obiettivo di sviluppare un modello di Educazione Terapeutica al Paziente (ETP) per la gestione dell’asma nel bambino, al fine di raggiungere un buon controllo dei sintomi, con conseguente m…

The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta‐review of meta‐analyses of randomized controlled trials

2019

The role of nutrition in mental health is becoming increasingly acknowledged. Along with dietary intake, nutrition can also be obtained from "nutrient supplements", such as polyunsaturated fatty acids (PUFAs), vitamins, minerals, antioxidants, amino acids and pre/probiotic supplements. Recently, a large number of meta-analyses have emerged examining nutrient supplements in the treatment of mental disorders. To produce a meta-review of this top-tier evidence, we identified, synthesized and appraised all meta-analyses of randomized controlled trials (RCTs) reporting on the efficacy and safety of nutrient supplements in common and severe mental disorders. Our systematic search identified 33 me…

Development of a New Clusterization Method for the GEM-TPC Detector

2022

The Facility for Antiproton and Ion Research FAIR, in Darmstadt Germany, will be one of the largest accelerator laboratories worldwide. The Superconducting FRagment Separator (Super-FRS)* is one of its main components. The Super-FRS can produce, separate and deliver high-energy radioactive beams with intensities up to 1e11 ions/s, covering projectiles from protons up to uranium and it can be used as an independent experimental device. The Gas Electron Multiplier-based Time Projection Chambers (GEM-TPC) in twin configuration is a newly developed beam tracking detector capable of providing spatial resolution of less than 1 mm with a tracking efficiency close to 100% at 1 MHz counting rate. Th…

Quadratic least-squares formulation for a local active noise control with stochastic domain and noise source

2012

A local active noise control method that uses stochastic numerical acoustical modeling is introduced. The frequency domain acoustical simulations are performed by a sequence solutions to Helmholtz equations approximated by FEM. The proposed ANC method maps microphone measurements linearly to the output signals of antinoise actuators. The matrix defining the linear mapping is optimized for each frequency to minimize expected value of the noise. The paper concentrates on defining the quadratic least-squares optimization problem for the minimization of the sound pressure field in the silet region. The formulation leads to a robust and accurate noise control in stochastic domains that has a sto…

Optimal control in models with conductive‐radiative heat transfer

2003

In this paper an optimal control problem for the elliptic boundary value problem with nonlocal boundary conditions is considered. It is shown that the weak solutions of the boundary value problem depend smoothly on the control parameter and that the cost functional of the optimal control problem is Frechet differentiable with respect to the control parameter. Optimalus valdymas modeliuose su laidžiu-radioaktyviu šilumos pernešimu Santrauka Darbe nagrinejamas nelokalaus kraštinio uždavinio optimalaus valdymo uždavinys. Parodyta, kad silpnasis kraštinio uždavinio sprendinys tolydžiai priklauso nuo valdomojo parametro, taigi, optimalaus valdymo tikslo funkcija yra diferencijuojama Freše prasme…