Search results for " DAC"
showing 6 items of 26 documents
Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth.
2013
International audience; Dacarbazine (DTIC) is a cytotoxic drug widely used for melanoma treatment. However, the putative contribution of anticancer immune responses in the efficacy of DTIC has not been evaluated. By testing how DTIC affects host immune responses to cancer in a mouse model of melanoma, we unexpectedly found that both natural killer (NK) and CD8(+) T cells were indispensable for DTIC therapeutic effect. Although DTIC did not directly affect immune cells, it triggered the upregulation of NKG2D ligands on tumor cells, leading to NK cell activation and IFNγ secretion in mice and humans. NK cell-derived IFNγ subsequently favored upregulation of major histocompatibility complex cl…
Autour de Pierre Dac
2020
Publié à l'occasion de l'exposition présentée au Musée d'art et d'histoire du Judaïsme à Paris, du 15 octobre 2020 au février 2021.; International audience; No abstract.
Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment.
2015
The immunostimulatory ability of synthetic oligonucleotides containing CpG motifs (CpG-ODN), agonists of Toll-like receptor 9 (TLR9), can be harnessed to promote antitumor immunity by their application at the tumor site to stimulate local activation of innate immunity; however, particularly in the lung, tumor-associated immunosuppression can subvert such antitumor innate immune responses. To locally maintain continuous activation of innate subpopulations while inhibiting immunosuppressive cells, we evaluated aerosol delivery CpG-ODN combined with Poly(I:C), a TLR3 agonist able to convert tumor-supporting macrophages to tumoricidal effectors, in the treatment of B16 melanoma lung metastases …
Desarrollo de nuevas estrategias en cromatografía líquida para el análisis de muestras complejas
2023
Desde los años 70, el uso de la cromatografía líquida de alta resolución (HPLC, High Performance Liquid chromatography) ha ido creciendo en los laboratorios analíticos, siendo actualmente la técnica de separación analítica más utilizada. Desafortunadamente, la eficacia suele ser menor que la que se logra en otras técnicas de separación como la cromatografía de gases y la electroforesis capilar. Esto restringe el análisis de muestras complejas. De ahí el gran esfuerzo dedicado a aumentar la eficacia y selectividad en HPLC, con importantes mejoras desde el inicio de la técnica. A pesar de los avances en las últimas décadas, con el desarrollo de instrumentación cada vez más sofisticada, y la m…
Bermudagrass adaptation in the Mediterranean climate: phenotypic traits of 44 accessions
2014
The use of bermudagrass in the Mediterranean area is increasing for its outstanding tolerance to heat and drought, and its aggressive growth and high recuperative potential make it particularly suited to heavily worn areas and appreciated for sports turfs. However, the overall performance of a given genetic type can be affected by the adaptation to a specific environment. The objective of this research was to determine the variability of a number of phenotypic traits that can affect bermudagrass turf performance on a wide range of bermudagrass accessions grown in two locations in Italy. In May 2010, 44 accessions of bermudagrasses, grouped in “wild”, “improved” “hybrid” and “dwarf” types we…
Kustaa Vaasan valtakauden alkupuoli analyysin kohteena
2021
Arvio teoksesta Ylikangas, Heikki. Kustaa Vaasa ja hänen uhmaajansa. Kristian II:sta Nils Dackeen. Siltala 2021. 336 s. ISBN 9789522348098. nonPeerReviewed