Search results for " DEMENTIA"

showing 5 items of 165 documents

Subventricular zone in motor neuron disease with frontotemporal dementia.

2011

Investigate how the subventricular proliferation and organisation is modified in a patient with FTLD-ALS. We studied the subventricular zone (SVZ) of a patient with FTLD-ALS immunohistochemical and histologically. We found an increase of Ki-67 positive cells and neuroblast in the subventricular zone, suggesting an activation of proliferating activity in response to FTD-ALS. This proliferation can act as a compensatory mechanism for rapid neuronal death and its modulation could provide a new therapeutic pathway in ALS. These results suggest a modification of neurogenesis in FTD-ALS. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

TelencephalonSubventricular zoneanimal diseasesNeurogenesisSubventricular zoneBiologyFrontotemporal lobar degenerationNeuroblastNeural Stem Cellsmental disordersmedicineHumansMotor neuron diseaseAmyotrophic lateral sclerosisMotor Neuron DiseaseAgedGeneral NeuroscienceNeurogenesisAmyotrophic Lateral Sclerosisnutritional and metabolic diseasesFrontotemporal lobar degenerationMotor neuronmedicine.diseaseNeural stem cellnervous system diseasesmedicine.anatomical_structurenervous systemFrontotemporal DementiaNerve DegenerationFemaleAmyotrophic lateral SclerosisNeuroscienceFrontotemporal dementiaNeuroscience letters
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P4‐244: Progranulin (GRN), a protein mutated in frontotemporal dementia with ubiquitin‐positive inclusions (FTLD‐U), is abundantly expressed in human…

2009

EpidemiologyHealth PolicyA proteinBiologymedicine.diseaseUbiquitin-positive inclusionsPsychiatry and Mental healthCellular and Molecular NeuroscienceDevelopmental NeuroscienceCancer researchmedicineNeurology (clinical)Geriatrics and GerontologyFrontotemporal dementiaAlzheimer's & Dementia
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Low-Dose Aspirin Use and Cognitive Function in Older Age: A Systematic Review and Meta-analysis

2017

Objectives:\ud \ud To investigate whether low-dose aspirin (<300 mg/d) can influence the onset of cognitive impairment or dementia in observational studies and improve cognitive test scores in randomized controlled trials (RCTs) in participants without dementia.\ud \ud Design:\ud \ud Systematic review and meta-analysis.\ud \ud Setting:\ud \ud Observational and interventional studies.\ud \ud Participants:\ud \ud Individuals with no dementia or cognitive impairment initially.\ud \ud Measurements:\ud \ud Odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for the maximum number of covariates from each study, were used to summarize data on the incidence of dementia and cognitive impa…

Gerontologymedicine.medical_specialtyaspirinArticlelaw.invention03 medical and health sciencesCognition0302 clinical medicineRandomized controlled triallawaspirin; cognitive impairment; dementia; meta-analysis; Geriatrics and GerontologyInternal medicinemedicineHumansDementia030212 general & internal medicineCognitive declineRandomized Controlled Trials as Topiccognitive impairmentbusiness.industryAnti-Inflammatory Agents Non-SteroidalCognitionOdds ratiomedicine.diseaseCognitive testmeta-analysisMeta-analysisDementiaObservational studyGeriatrics and GerontologyCognition Disordersbusiness030217 neurology & neurosurgery
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Muistisairaan ihmisen kokemukset teknologiasta osana arkea - turvaa vai tunkeilevuutta

2018

Tässä tutkimuksessa selvitettiin muistisairaiden ihmisten arkea tukevan teknologian käyttöönottoa ja heidän sekä heidän läheistensä kokemuksia teknologian käytöstä. Tutkimuksen viitekehyksenä toimi Lawtonin ekologinen malli. Tutkimuksessa käytettiin etnografista näkökulmaa haastattelemalla ja havainnoimalla muistisairaita ihmisiä teknologian käyttötilanteissa. Ensimmäinen vaihe toteutettiin vuosina 2004-2007. Ensimmäisessä vaiheessa kohderyhmänä olivat 25 muistisairautta sairastavaa kotona yksin tai omaishoitajansa kanssa asuvaa henkilöä sekä heidän läheistään ja viisi vastaajaa kuntien kotihoidosta. Koteihin vietiin yhteensä 29 erilaista laitetta. Toinen keruuvaihe toteutettiin vuosina 201…

ethicalitykotihoitoLawtonin ekologinen mallitekniikka (laitteet)experienceomaishoitajatseurantaomaishoitomuistisairaudetautonomiapeople with dementiaapuvälineettracking technologymobilitystigmatliikkuvuusikääntyminensatelliittipaikannustechnologykokemuksetteknologiaetäseurantaliikkumineninsecuritymuistisairaatdementiaturvattomuus
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Thalamic stroke mimicking frontotemporal dementia: a case report

2012

Background: The behavioral variant of frontotemporal dementia (bvFTD) is characterized by changes of personality, social behavior and cognition and relies on a neurodegenerative process. However, vascular lesions affecting subcortical structures may result in a clinical syndrome resembling bvFTD. Objective: To describe a case of thalamic stroke resulting in frontal dementia. Case report: A 58-year-old man was referred to our hospital because of behavioral and cognitive changes formerly diagnosed as bvFTD. In 2010, he suddenly presented loss of consciousness and in the next days he developed amnesia, apathy and personality changes. Toxicological exams, CSF analysis and CT scan were normal at…

dementia stroke frontotemporal dementia
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