Search results for " DESIGN."
showing 10 items of 4909 documents
Gender differences in usage and user experience of Oiva App
2015
Previous research has indicated that gender is an important demographic to consider when designing effective and tailored technology interventions. Despite this need, gender differences is still an understudied topic in the field of technology interventions. The objective of this study was to study gender differences in usage and user experience of a mental wellness app called Oiva. Gender differences in the app’s effect on the participants’ mental well-being were also investigated. Oiva is a stand-alone mental wellness app that aims to increase its users’ psychological flexibility by teaching Acceptance and Commitment Therapy (ACT) based skills. The study population of the current study wa…
An EEMD Aided Comparison of Time Histories and Its Application in Vehicle Safety
2017
In the context of signal processing, the comparison of time histories is required for different purposes, especially for the model validation of vehicle safety. Most of the existing metrics focus on the mathematical value only. Therefore, they suffer the measuring errors, disturbance, and uncertainties and can hardly achieve a stable result with a clear physical interpretation. This paper proposes a novel scheme of time histories comparison to be used in vehicle safety analysis. More specifically, each signal for comparison is decomposed into a trend signal and several intrinsic mode functions (IMFs) by ensemble empirical mode decomposition. The trend signals reflect the general variation a…
Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening.
2015
In drug discovery the reliable prediction of binding free energies is of crucial importance. Methods that combine molecular mechanics force fields with continuum solvent models have become popular because of their high accuracy and relatively good computational efficiency. In this research we studied the performance of molecular mechanics generalized Born surface area (MM-GBSA), molecular mechanics Poisson-Boltzmann surface area (MM-PBSA), and solvated interaction energy (SIE) both in their virtual screening efficiency and their ability to predict experimentally determined binding affinities for five different protein targets. The protein-ligand complexes were derived with two different app…
In pursuit of beginning teachers'competence in promoting reading motivation: a mixed-methods study into the impact of a contunuing professional devel…
2020
As teachers’ reading motivation and self-efficacy for promoting reading motivation can be considered vital for their reading-oriented promotive teaching practices and students’ reading motivation, this study evaluated the impact of a year-long CPD program for beginning primary school teachers. A convergent parallel mixed-methods design with repeated measures was established, including a comparison and two CPD conditions (group vs. individually-oriented). Based on the quantitative results only no clear impact of and differences between the conditions could be observed. The qualitative analysis, however, showed growth in teachers’ reading motivation and self-efficacy at a different pace and l…
Tempting to Tag : An Experimental Comparison of Four Tagging Input Mechanisms
2010
Tagging helps achieve improved indexing and recommendation of resources (e.g., videos or pictures) in large data collections. In order to reap the benefits of tagging, people must be persuaded to label the resources they consume. This paper reports on a study in which four different tagging input mechanisms and their effect on users’ motivation to tag were compared. The mechanisms consisted of a standard tag input box, a chatbot-like environment, a bookmarking mechanism, and a “tag and vote” game. The results of our experiment show that the use of the nonstandard tagging input mechanisms does not affect users’ motivation to tag. In some instances tagging mechanisms were found to distract us…
Conocimiento, traza e ingenio en la arquitectura valenciana del siglo XV
2012
In the last decades historiography of gothic architecture in the Crown of Aragon has focused on buildings monographs, documentary research and technical change in stone building. On the other hand, historians of technology have given special attention to the issue of innovation and its diffusion in the late Middle Ages, considering building techniques as a particular field of research. This essay studies transmission of technical knowledge in building trades in order to explain architectural changes in an outstanding environment of innovation such as the kingdom of Valencia in the 14th and 15th centuries, especially from 1430 onwards. Having account of previous research and some cases of st…
Pareto frontier in economic-statistical design of a dynamic c chart
2015
The present paper proposes an economic-statistical multi-objective design procedure for a dynamic c control chart. In detail, a mixed integer non-linear constrained mathematical model is formulated to solve the treated problem, whereas the Pareto frontier is described by the ε-constraint method. To show the employment of the proposed procedure a numerical case is solved and the related considerations are given.
Structural Design of Frames Able to Prevent Element Buckling
2012
Two formulations of a special multicriterion optimal design problem devoted to elastic perfectly plastic steel frame structures subjected to different combinations of static and dynamic loads are presented. In particular, two minimum volume design problem formulations are proposed: in the first one the structure is designed so as to be able to elastically behave for the assigned fixed loads, to elastically shakedown for serviceability seismic load conditions and to prevent the instantaneous collapse for suitably chosen combinations of fixed and ultimate seismic loadings; in the second one the structure must also satisfy further appropriate constraints related to element buckling. The action…
Myotonic dystrophy: candidate small molecule therapeutics
2017
Myotonic dystrophy type 1 (DM1) is a rare multisystemic neuromuscular disorder caused by expansion of CTG trinucleotide repeats in the noncoding region of the DMPK gene. Mutant DMPK transcripts are toxic and alter gene expression at several levels. Chiefly, the secondary structure formed by CUGs has a strong propensity to capture and retain proteins, like those of the muscleblind-like (MBNL) family. Sequestered MBNL proteins cannot then fulfill their normal functions. Many therapeutic approaches have been explored to reverse these pathological consequences. Here, we review the myriad of small molecules that have been proposed for DM1, including examples obtained from computational rational …
The Retrograde Tibial Nail: presentation and biomechanical evaluation of a new concept in the treatment of distal tibia fractures.
2013
Displaced distal tibia fractures require stable fixation while minimizing secondary damage to the soft tissues by the surgical approach and implants. Antegrade intramedullary nailing has become an alternative to plate osteosynthesis for the treatment of distal metaphyseal fractures over the past two decades. While retrograde intramedullary nailing is a standard procedure in other long bone fractures, only few attempts have been made on retrograde nailing of tibial fractures. The main reasons are difficulties of finding an ideal entry portal and the lack of an ideal implant for retrograde insertion. The Retrograde Tibial Nail (RTN) is a prototype intramedullary implant developed by our group…