Search results for " DIP"
showing 10 items of 1273 documents
Energetic aspects of intramolecular coupling between the nucleotide binding site and the distal switch II region of the yeast RAS2 protein
1994
AbstractWe have studied the interaction of the yeast RAS2 protein with guanine nucleotides using energetic parameters for the dissociation of RAS·nucleotide complexes. The results indicated that a Gly → Ser substitution at position 82 led to an altered interaction with GppNHp and, to a lesser extent, also with GDP. It was also possible to conclude that structural perturbation of Gly82 can stimulate nucleotide release by decreasing the energetic barrier for nucleotide dissociation. This, together with the observation that residues 80 and 81 are involved in the response of RAS to nucleotide exchange factors without affecting GDP binding per se, suggests a potential mechanism for exchange fact…
Madonie, L'arte e la storia
2021
Il volume esamina il patrimonio storico artistico dei seguenti paesi delle Madonie: Caltavuturo, Castelbuono, Cefalù, Collesano, Geraci Siculo, Gangi, Gratteri, Isnello, Petralia Soprana, Petralia Sottana, Polizzi Generosa, Pollina, San Mauro Castelverde e Sclafani Bagni. Per ogni singolo borgo si affronta brevemente la storia della città e successivamente si esaminano le chiese e le opere d’arte ivi contenute, iniziando dalla Chiesa Madre o dalla Basilica per poi continuare con gli altri edifici chiesastici e i palazzi nobiliari. Particolare attenzione viene riservata all’architettura, come le chiese medievali e rinascimentali di Castelbuono, Gratteri e Isnello o quelle barocche e rococò d…
L’archéologue classique aux prises avec le monde diplomatique. Le cas de Salomon Reinach en 1881
2017
Classical Archeology Clashing with the World of Diplomacy: the Case of Salomon Reinach in 1881 Studies on the ties between archeology and diplomacy focus mostly on the way a few individuals reconciled a double career and realized the ideal of a hybrid figure: the diplomat as archeologist. Less attention has been paid to the relations, on a daily basis, between classical archeology and the world of consulates and embassies in the Eastern Mediterranean. Most of the time, one relies on the widespread cliché of the archeologist as a victim of bureaucracy. The case studied here is that of Salomon Reinach (1858-1932) and his abundant correspondence, held by the bibliothèque Méjanes (Aix-en-Proven…
Knowledge exchange through science diplomacy to assist disaster risk reduction
2021
Abstract This paper analyses science diplomacy efforts to reduce disaster risks and proposes establishing national knowledge exchange centers (KECs) to help individual states adhere to their Sendai Framework goals. KECs are considered to be interconnected globally and work together to promote resilience efforts by facilitating sharing of information and strategies in risk monitoring, assessment, and ultimately reduction across the globe. KECs can provide high-quality scientific evidence for informed decisionmaking along with a component related to disaster science media to ensure that appropriate knowledge reaches a variety of people who need it in different forms tailored for them. KECs ca…
A raíz de un divisor argénteo de probable atribución a Malaka aparecido junto a un tartemorion gaditano en Cástulo
2015
Este artículo documenta el hallazgo fortuito de un divisor de plata posiblemente atribuible a Malaka que apareció junto a un tartemo rion de Gadir en las inmediaciones de la ciudad ibero-romana de Cástulo, en el Cortijo de Ca zlona (Linares, Jaén). El hallazgo de estas dos piezas juntas, nos indica que ambas fueron cont emporáneas tanto en su circulación como, muy quizás, en su acuñación. Asimismo, el artículo recoge todos los ejemplares de divisores de plata y asignados a Malaka conocidos hasta el momen to. Finalmente, se acomete una primera aproximación de la seriación y de los cuños utiliza dos para dichas monedas. This paper documents the fortuitous discovery of a silver fraction, possi…
Crustal Structure of the Seismogenic Volume of the 2010–2014 Pollino (Italy) Seismic Sequence From 3D P- and S-Wave Tomographic Images
2021
A tomographic analysis of Mt. Pollino area (Italy) has been performed using earthquakes recorded in the area during an intense seismic sequence that occurred between 2010 and 2014. 870 local earthquakes with magnitude ranging from 1.8 to 5.0 were selected considering the number of recording stations, the signal quality, and the hypocenter distribution. P- and S-wave arrival times were manually picked and used to compute 3D velocity models through tomographic seismic inversion. The resulting 3D distributions of VP and VS are characterized by high resolution in the central part of the investigated area and from surface to about 10 km below sea level. The aim of the work is to obtain high-qual…
Inhibition of FcεRI-mediated Activation of Rat Basophilic Leukemia Cells by Clostridium difficile Toxin B (Monoglucosyltransferase)
1996
Abstract Treatment of rat basophilic leukemia (RBL) 2H3-hm1 cells with Clostridium difficile toxin B (2 ng/ml), which reportedly depolymerizes the actin cytoskeleton, blocked [3H]serotonin release induced by 2,4-dinitrophenyl-bovine serum albumin, carbachol, mastoparan, and reduced ionophore A23187-stimulated degranulation by about 55-60%. In lysates of RBL cells, toxin B 14C-glucosylated two major and one minor protein. By using two-dimensional gel electrophoresis and immunoblotting, RhoA and Cdc42 were identified as protein substrates of toxin B. In contrast to toxin B, Clostridium botulinum transferase C3 that selectively inactivates RhoA by ADP-ribosylation did not inhibit degranulation…
Persistent Organic Pollutants and Fatty Acid Profile in a Typical Cheese from Extensive Farms: First Assessment of Human Exposure by Dietary Intake
2022
Dairy products represent an important source of beneficial substances for humans. At the same time, they can expose the consumers to environmental contaminants ingested by animals through their diet, influencing their health negatively. This experiment aims to evaluate the risk and benefits related to the consumption of typical stretched cheeses, considering their fatty acid (FA) profile and persistent organic pollutants (POPs) content. Six representative farms, two of them organic, raising Cinisara cattle were selected, considering the typical extensive management systems, based on feeding of natural pasture integrated with concentrate and hay depending on the availability of forage on pas…
A study of the pattern of digestive enzimes in Diplodus puntazzo (Cetti, 1777) (Osteychthyes, Sparidae): evidence for the definition of nutritional p…
2005
The digestive enzymes (proteases, carbohydrases and lipases) present along the alimentary tract of juveniles and adults of Diplodus puntazzo were studied. The data obtained showed a different distribution of the enzymatic activities in the different parts of the alimentary tract. Levels of enzymatic activity in the adults were higher than those measured in juveniles, suggesting that adults have a greater ability to digest larger pieces of food. The enzymatic pattern of D. puntazzo justifies its omnivorous habit and suggests an high potential for digesting vegetable polysaccharides. The results of this study suggest the need to adapt the diet to the digestive potential of this new farming sp…